水谷仁 (Hitoshi Mizutani) - マイポータル

基本情報

所属: 三重大学大学院医学系研究科皮膚医学分野教授,教授,教授

学位: 医学博士

J-GLOBAL ID: 200901010684788977
researchmap会員ID: 1000025707

研究キーワード

研究分野

委員歴

受賞

1992年

三医会賞

論文

CD8+T cell granzyme B activates keratinocyte endogenous IL-18

Tomoko Akeda, Keiichi Yamanaka, Kenshiro Tsuda, Youichi Omoto, Esteban C. Gabazza, Hitoshi Mizutani

ARCHIVES OF DERMATOLOGICAL RESEARCH 306(2) 125-130 2014年3月査読有り
Novel acoustic evaluation system for scratching behavior in itching dermatitis: Rapid and accurate analysis for nocturnal scratching of atopic dermatitis patients

Yuichi Noro, Youichi Omoto, Koji Umeda, Futa Tanaka, Yousuke Shiratsuka, Tomomi Yamada, Kenichi Isoda, Kimiko Matsubara, Keiichi Yamanaka, Esteban C. Gabazza …

JOURNAL OF DERMATOLOGY 41(3) 233-238 2014年3月査読有り
Continuous high-dose antigen exposure preferentially induces IL-10, but intermittent antigen exposure induces IL-4

Keiichi Yamanaka, Takehisa Nakanishi, Jun Watanabe, Makoto Kondo, Akisa Yamagiwa, Esteban C. Gabazza, Hitoshi Mizutani

EXPERIMENTAL DERMATOLOGY 23(1) 63-65 2014年1月査読有り
The Majority of Generalized Pustular Psoriasis without Psoriasis Vulgaris Is Caused by Deficiency of Interleukin-36 Receptor Antagonist

Kazumitsu Sugiura, Akemi Takemoto, Michiya Yamaguchi, Hidetoshi Takahashi, Yukiko Shoda, Teruyuki Mitsuma, Kenshiro Tsuda, Emi Nishida, Yaei Togawa, Kimiko Nakajima …

JOURNAL OF INVESTIGATIVE DERMATOLOGY 133(11) 2514-2521 2013年11月査読有り
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice

Yasutomo Imai, Koubun Yasuda, Yoshiko Sakaguchi, Takashi Haneda, Hitoshi Mizutani, Tomohiro Yoshimoto, Kenji Nakanishi, Kiyofumi Yamanishi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110(34) 13921-13926 2013年8月査読有り
Mutant interleukin-4/13 signaling blockade successfully suppresses acute phase inflammation

Takehisa Nakanishi, Keiichi Yamanaka, Masato Kakeda, Kenshiro Tsuda, Hitoshi Mizutani

ARCHIVES OF DERMATOLOGICAL RESEARCH 305(3) 241-247 2013年4月査読有り
Presence of antiphospholipid antibody is a risk factor in thrombotic events in patients with antiphospholipid syndrome or relevant diseases

Koji Habe, Hideo Wada, Takeshi Matsumoto, Kohshi Ohishi, Makoto Ikejiri, Kimiko Matsubara, Tatsuhiko Morioka, Yuki Kamimoto, Tomoaki Ikeda, Naoyuki Katayama …

INTERNATIONAL JOURNAL OF HEMATOLOGY 97(3) 345-350 2013年3月査読有り
Intranasally administered antigen 85B gene vaccine in non-replicating human Parainfluenza type 2 virus vector ameliorates mouse atopic dermatitis.

Hiroshi Kitagawa, Mitsuo Kawano, Keiichi Yamanaka, Masato Kakeda, Kenshiro Tsuda, Hiroyasu Inada, Misao Yoneda, Tadashi Sakaguchi, Akina Nigi, Koumei Nishimura …

PloS one 8(7) e66614 2013年査読有り
Two Patients with Antiphospholipid Antibody Developed Disseminated Intravascular Coagulation

Koji Habe, Hideo Wada, Naomi Ito-Habe, Hikoji Suzuki, Tsutomu Nobori, Hitoshi Mizutani

INTERNAL MEDICINE 52(2) 269-272 2013年査読有り
Ustekinumab Improves Psoriasis without Altering T Cell Cytokine Production, Differentiation, and T Cell Receptor Repertoire Diversity

Kenshiro Tsuda, Keiichi Yamanaka, Makoto Kondo, Kimiko Matsubara, Ryogen Sasaki, Hidekazu Tomimoto, Esteban C. Gabazza, Hitoshi Mizutani

PLOS ONE 7(12) e51819 2012年12月査読有り
Plasma ADAMTS13, von Willebrand Factor (VWF) and VWF Propeptide Profiles in Patients with DIC and Related Diseases

Koji Habe, Hideo Wada, Naomi Ito-Habe, Tsuyoshi Hatada, Takeshi Matsumoto, Kohshi Ohishi, Kazuo Maruyama, Hiroshi Imai, Hitoshi Mizutani, Tsutomu Nobori

THROMBOSIS RESEARCH 129(5) 598-602 2012年5月査読有り
Single step modified ink staining for Tzanck test: Quick detection of herpetic giant cells in Tzanck smear

Hitoshi Mizutani, Tomoko Akeda, Kei-ichi Yamanaka, Kenichi Isoda, Esteban C. Gabazza

JOURNAL OF DERMATOLOGY 39(2) 138-140 2012年2月査読有り
Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naïve T cells into cytokine-producing mature T cells.

Tsuda K, Yamanaka K, Kitagawa H, Akeda T, Naka M, Niwa K, Nakanishi T, Kakeda M, Gabazza EC, Mizutani H

PloS one 7 e31465 2012年査読有り
Intratumoral Injection of Propionibacterium acnes Suppresses Malignant Melanoma by Enhancing Th1 Immune Responses

Kenshiro Tsuda, Keiichi Yamanaka, Wang Linan, Yoshihiro Miyahara, Tomoko Akeda, Takehisa Nakanishi, Hiroshi Kitagawa, Masato Kakeda, Ichiro Kurokawa, Hiroshi Shiku …

PLOS ONE 6(12) e29020 2011年12月査読有り
Keratin and filaggrin expression in comedonal Darier's disease

Ichiro Kurokawa, Daisuke Tsuruta, Airo Tsubura, Hitoshi Mizutani

JOURNAL OF DERMATOLOGY 38(11) 1089-1092 2011年11月査読有り
Treatment of cloth with a fabric softener ameliorates skin dryness

Kenichi Isoda, Yutaka Takagi, Takashi Kitahara, Yutaka Sano, Ikuo Sugano, Kumi Umeda-Togami, Koji Umeda, Keiichi Yamanaka, Tomomi Yamada, Hitoshi Mizutani

JOURNAL OF DERMATOLOGY 38(7) 685-692 2011年7月査読有り
The role of cytokines/chemokines in the pathogenesis of atopic dermatitis

Kei-Ichi Yamanaka, Hitoshi Mizutani

Current Problems in Dermatology 41 80-92 2011年5月査読有り
Contribution of interleukin 18 to the development of infection-associated atopic dermatitis

Hiroko Tsutsui, Hitoshi Mizutani, Kenji Nakanishi

Current Problems in Dermatology 41 93-103 2011年5月査読有り
Propionibacterium acnes vaccination induces regulatory T cells and Th1 immune responses and improves mouse atopic dermatitis

Hiroshi Kitagawa, Keiichi Yamanaka, Masato Kakeda, Hiroyasu Inada, Yasutomo Imai, Esteban C. Gabazza, Ichiro Kurokawa, Hitoshi Mizutani

EXPERIMENTAL DERMATOLOGY 20(2) 157-158 2011年2月査読有り
SLIT improves cedar pollinosis by restoring IL-10 production from Tr1 and Monocytes∼IL-10 productivity is critical for becoming allergic∼.

Yamanaka K, Yuta A, Kakeda M, Kitagawa H, Ogihara H, Gabazza EC, Okubo K, Kurokawa I, Takeuchi K, Mizutani H

Allergology international : official journal of the Japanese Society of Allergology 60(1) 45-51 2011年査読有り

もっとみる

MISC

Increased interferon-gamma, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris Host response but not bacterial species is the determinant factor of the disease

Hitomi Sugisaki, Keiichi Yamanaka, Masato Kakeda, Hiroshi Kitagawa, Kaori Tanaka, Kunitomo Watanabe, Esteban C. Gabazza, Ichiro Kurokawa, Hitoshi Mizutani

JOURNAL OF DERMATOLOGICAL SCIENCE 55(1) 47-52 2009年7月
IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis

T. Morioka, K. Yamanaka, H. Mori, Y. Omoto, K. Tokime, M. Kakeda, I. Kurokawa, E. C. Gabazza, A. Tsubura, Y. Yasutomi …

BRITISH JOURNAL OF DERMATOLOGY 160(6) 1172-1179 2009年6月
Administration of Ag85B showed therapeutic effects to Th2-type cytokine-mediated acute phase atopic dermatitis by inducing regulatory T cells

Hitoshi Mori, Keiichi Yamanaka, Kazuhiro Matsuo, Ichiro Kurokawa, Yasuhiro Yasutomi, Hitoshi Mizutani

ARCHIVES OF DERMATOLOGICAL RESEARCH 301(2) 151-157 2009年2月
Enhanced production and secretion of glial cell line-derived neurotrophic factor and nerve growth factor from the skin in atopic dermatitis mouse model

Kazuya Tokime, Ritsuko Katoh-Semba, Keiichi Yamanaka, Akira Mizoguchi, Hitoshi Mizutani

ARCHIVES OF DERMATOLOGICAL RESEARCH 300(7) 343-352 2008年8月
Freshly isolated Langerhans cells negatively regulate naive T cell activation in response to peptide antigen through cell-to-cell contact

Yasutomo Imai, Nobuki Hayashi, Koubun Yasuda, Hiroko Tsutsui, Hitoshi Mizutani, Kenji Nakanishi

JOURNAL OF DERMATOLOGICAL SCIENCE 51(1) 19-29 2008年7月
Protective role of interleukin-18 against Fas-mediated liver injury

Yamamoto N, Murata K, Yoneda K, Fuke H, Yamaguchi Y, Ito K, Sugimoto K, Shiraki K, Yamanaka K, Mizutani H …

Int J Mol Med. 22(1) 43-8 2008年
A novel acoustic evaluation system of scratching in mouse dermatitis: Rapid and specific detection of invisibly rapid scratch in an atopic dermatitis model mouse

Koji Umeda, Yuichi Noro, Takaaki Murakami, Kazuya Tokime, Hitomi Sugisaki, Keiichi Yamanaka, Ichiro Kurokawa, Kazuhiro Kuno, Hiroko Tsutsui, Kenji Nakanishi …

LIFE SCIENCES 79(22) 2144-2150 2006年10月
Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment.

Omoto Y, Tokime K, Yamanaka K, Habe K, Morioka T, Kurokawa I, Tsutsui H, Yamanishi K, Nakanishi K, Mizutani H

J Immunol. 177(12) 8315-9. 2006年
Cytokeratin, filaggrin, and p63 expression in reepithelialization during human cutaneous wound healing

Kurokawa, I, H Mizutani, K Kusumoto, S Nishijima, M Tsujita-Kyutoku, N Shikata, A Tsubura

WOUND REPAIR AND REGENERATION 14(1) 38-45 2006年1月
Induction of allergic inflammation by interleukin-18 in experimental animal models.

Tsutsui H, Yoshimoto T, Hayashi N, Mizutani H, Nakanishi K

Immunol Rev. 202 115-38 2004年
Persistent secretion of IL-18 in the skin contributes to IgE response in mice

H Nakano, H Tsutsui, M Terada, K Yasuda, K Matsui, S Yumikura-Futatsugi, K Yamanaka, H Mizutani, T Yamamura, K Nakanishi

INTERNATIONAL IMMUNOLOGY 15(5) 611-621 2003年5月
IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions

H Konishi, H Tsutsui, T Murakami, S Yumikura-Futatsugi, K Yamanaka, M Tanaka, Y Iwakura, N Suzuki, K Takeda, S Akira …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(17) 11340-11345 2002年8月
Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18

K Yamanaka, M Tanaka, H Tsutsui, TS Kupper, K Asahi, H Okamura, K Nakanishi, M Suzuki, N Kayagaki, RA Black …

JOURNAL OF IMMUNOLOGY 165(2) 997-1003 2000年7月
IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6.

Yoshimoto T, Mizutani H, Tsutsui H, Noben-Trauth N, Yamanaka K, Tanaka M, Izumi S, Okamura H, Paul WE, Nakanishi K

Nat Immunol. 1(2) 132-7. 2000年
Cassiopeia flap : Modification of Limberg flap for saving normal skin. (共著)

Journal of Dermatology (27) 217-219 2000年
Tocoretinate inhibited the contraction of collagen gel matrices by human dermal fibroblasts with tenascin-C expression. (共著)

Journal of Dermatological Science (22) 45-53 1999年
Anti-elongation factor-alpha 1 autoantibody in adult atopic dermatitis patients. (共著)

International Immunology 11(10) 1635-1640 1999年
Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. (共著)

Journal of Clinical Investigation (104) 1097-105 1999年
Intradermal transfer of caspase-1(CASP1)DNA into mouse dissects role of CASP1 in interleukin-1 beta associated skin inflammation and apoptotic cell death. (共著)

Journal of Dermatological Science (21) 49-58 1999年
Endogenous neutralizing anti-lL-1 alpha autoantibodies in inflammatory skin diseases : possible natural inhibitor for over expressed epidermal lL-1. (共著)

Journal of Dermatological Science (20) 63-71 1999年

もっとみる

書籍等出版物

Topical ceramide corrected epidermal cell hyperproliferation and stratum corneum dysmaturation in atopic eczema (共著)

New trends in allergy IV 1997年
遅延型過敏症:ヒト(PPDその他による反応)

免疫実験操作法 1995年
クリオグロブリン血症

皮膚疾患最新の治療'95-'96 1995年
乾癬とサイトカイン(共著)

乾癬とシクロスポリン,国際医学出版 1993年
Cytokine in Psoriasis

Ciclosporin in Psoriasis, kokusai igaku shuppan 1993年
強皮症、皮膚筋炎とその周辺

金原出版 1989年
Scleroderma, Dermatomyositis and related diseases

1989年

水谷仁

基本情報

研究キーワード

研究分野

委員歴

受賞

論文

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

メニュー