1996年5月
In vitro development of primitive and definitive erythrocytes from different precursors
SCIENCE
- ,
- ,
- 巻
- 272
- 号
- 5262
- 開始ページ
- 722
- 終了ページ
- 724
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.272.5262.722
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
During mouse embryogenesis the production of ''primitive'' erythrocytes (EryP) precedes the production of ''definitive'' erythrocytes (EryD) in parallel with the transition of the hematopoietic site from the yolk sac to the fetal liver. On a macrophage colony-stimulating factor-deficient stromal cell line OP9, mouse embryonic stem cells were shown to give rise to EryP and EryD sequentially with a time course similar to that seen in murine ontogeny. Studies of the different growth factor requirements and limiting dilution analysis of precursor frequencies indicate that most EryP and EryD probably developed from different precursors by way of distinct differentiation pathways.
- リンク情報
- ID情報
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- DOI : 10.1126/science.272.5262.722
- ISSN : 0036-8075
- Web of Science ID : WOS:A1996UJ05100051