成宮周 (Shuh Narumiya) - マイポータル

基本情報

所属: 京都大学大学院医学研究科医学専攻教授

学位: 医学博士

J-GLOBAL ID: 200901009342880504
researchmap会員ID: 1000026462

外部リンク: http://www5.mfour.med.kyoto-u.ac.jp/

研究キーワード

研究分野

委員歴

受賞

2005年

紫綬褒章
2002年

上原賞
2000年

Gold medal of FONDATIONE GIOVANNI
1999年

ベルツ賞
1999年

武田医学賞
1998年

大阪科学賞
1985年

日本生化学会奨励賞

論文

LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis. J Invest Dermatol.

成宮周

J Invest Dermatol. 139(5) 1010-1022 2019年5月査読有り
T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation.

Jinju Lee, Tomohiro Aoki, Dean Thumkeo, Ratklao Siriwach, Chengcan Yao, Shuh Narumiya

The Journal of allergy and clinical immunology 143(2) 631-643 2019年2月査読有り
Prostaglandin-cytokine crosstalk in chronic inflammation.

成宮周

Br J Pharmacol. 17(3) 337-354 2019年2月査読有り
Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.

Kazushi Morimoto, Ryoji Suno, Yunhong Hotta, Keitaro Yamashita, Kunio Hirata, Masaki Yamamoto, Shuh Narumiya, So Iwata, Takuya Kobayashi

Nature chemical biology 15(1) 8-10 2019年1月査読有り
Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.

Yosuke Toyoda, Kazushi Morimoto, Ryoji Suno, Shoichiro Horita, Keitaro Yamashita, Kunio Hirata, Yusuke Sekiguchi, Satoshi Yasuda, Mitsunori Shiroishi, Tomoko Shimizu …

Nature chemical biology 15(1) 18-26 2019年1月査読有り
mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.

成宮周

PLoS Biol. 16(9) e2004874 2018年9月査読有り
The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation.

成宮周

Neuron 99(3) 464-479 2018年8月査読有り
Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety.

成宮周

Sci Rep 8(1) 10454 2018年7月査読有り
Rho signaling research: history, current status and future directions.

成宮周

FEBS Lett 592(11) 1763-1776 2018年査読有り
Prostanoid Receptors

Takako Hirata, Shuh Narumiya

CHEMICAL REVIEWS 111(10) 6209-6230 2011年10月査読有り
453. Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II.

Kamijo H, Matsumura Y, Thumkeo D, Koike S, Masu M, Shimizu Y, Ishizaki T, Narumiya S

455. Genes Cells 16, 1012-1021. 2011年10月査読有り
International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

D. F. Woodward, R. L. Jones, S. Narumiya

PHARMACOLOGICAL REVIEWS 63(3) 471-538 2011年9月査読有り
Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake

Tomoyuki Mitsumori, Tomoyuki Furuyashiki, Toshihiko Momiyama, Akinori Nishi, Takahide Shuto, Takashi Hayakawa, Fumitaka Ushikubi, Shiho Kitaoka, Tomohiro Aoki, Haruhisa Inoue …

EUROPEAN JOURNAL OF NEUROSCIENCE 34(4) 594-604 2011年8月査読有り
A GPR40 Agonist GW9508 Suppresses CCL5, CCL17, and CXCL10 Induction in Keratinocytes and Attenuates Cutaneous Immune Inflammation

Tomoko Fujita, Toshiyuki Matsuoka, Tetsuya Honda, Kenji Kabashima, Takako Hirata, Shuh Narumiya

JOURNAL OF INVESTIGATIVE DERMATOLOGY 131(8) 1660-1667 2011年8月査読有り
PGE(2)-EP2 signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-kappa B

T. Aoki, M. Nishimura, T. Matsuoka, K. Yamamoto, T. Furuyashiki, H. Kataoka, S. Kitaoka, R. Ishibashi, A. Ishibazawa, S. Miyamoto …

BRITISH JOURNAL OF PHARMACOLOGY 163(6) 1237-1249 2011年7月査読有り
Prostaglandin E-2-prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression

Kitipong Soontrapa, Tetsuya Honda, Daiji Sakata, Chengcan Yao, Takako Hirata, Shohei Hori, Toshiyuki Matsuoka, Yoshihiro Kita, Takao Shimizu, Kenji Kabashima …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108(16) 6668-6673 2011年4月査読有り
Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years

Shuh Narumiya, Tomoyuki Furuyashiki

FASEB JOURNAL 25(3) 813-818 2011年3月査読有り
Stress responses: the contribution of prostaglandin E-2 and its receptors

Tomoyuki Furuyashiki, Shuh Narumiya

NATURE REVIEWS ENDOCRINOLOGY 7(3) 163-175 2011年3月査読有り
444. Deficiency of mDia, an Actin Nucleator, Disrupts Integrity of Neuroepithelium and Causes Periventricular Dysplasia.

Thumkeo D, Shinohara R, Watanabe K, Takebayashi H, Toyoda Y, Tohyama K, Ishizaki T, Furuyashiki T, Narumiya S

PLoS One, 6, e25465. 2011年査読有り
Rotational Movement of the Formin mDia1 Along the Double Helical Strand of an Actin Filament

Hiroaki Mizuno, Chiharu Higashida, Yunfeng Yuan, Toshimasa Ishizaki, Shuh Narumiya, Naoki Watanabe

SCIENCE 331(6013) 80-83 2011年1月査読有り

もっとみる

MISC

Prostaglandin E receptor EP1 controls impulsive behavior under stress

Y Matsuoka, T Furuyashiki, K Yamada, T Nagai, H Bito, Y Tanaka, S Kitaoka, F Ushikubi, T Nabeshima, S Narumiya

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(44) 16066-16071 2005年11月
Thromboxane A2 and prostaglandin F2α mediate inflammatory tachycardia.

Nat Med. 11(5) 562-566 2005年5月
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3

T Kunikata, H Yamane, E Segi, T Matsuoka, Y Sugimoto, S Tanaka, H Tanaka, H Nagai, A Ichikawa, S Narumiya

NATURE IMMUNOLOGY 6(5) 524-531 2005年5月
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis

F Oceguera-Yanez, K Kimura, S Yasuda, C Higashida, T Kitamura, Y Hiraoka, T Haraguchi, S Narumiya

JOURNAL OF CELL BIOLOGY 168(2) 221-232 2005年1月
Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice

T Kobayashi, Y Tahara, M Matsumoto, M Iguchi, H Sano, T Murayama, H Arai, H Oida, T Yurugi-Kobayashi, JK Yamashita …

JOURNAL OF CLINICAL INVESTIGATION 114(6) 784-794 2004年9月
Cdc42 and mDia3 regulate microtubule attachment to kinetochores

S Yasuda, F Oceguera-Yanez, T Kato, M Okamoto, S Yonemura, Y Terada, T Ishizaki, S Narumiya

NATURE 428(6984) 767-771 2004年4月
Actin polymerization-driven molecular movement of mDia1 in living cells.

Science 303, 2007-2010. 2004年
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death

D Thumkeo, J Keel, T Ishizaki, M Hirose, K Nonomura, H Oshima, M Oshima, MM Taketo, S Narumiya

MOLECULAR AND CELLULAR BIOLOGY 23(14) 5043-5055 2003年7月
Prostaglandin E-2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells

K Kabashima, D Sakata, M Nagamachi, Y Miyachi, K Inaba, S Narumiya

NATURE MEDICINE 9(6) 744-749 2003年6月
Thromboxane A2 modulates dendritic cell-T cell interaction and regulates acquired immunity.

Nature Immunol. 4, 694-701 2003年
Control of axon elongation via an SDF-1α/Rho/mDia pathway in cultured cerebellar granule neurons.

J. Cell Biol. 161 381-391. 2003年
Prostaglandin E2-EP4 signaling facilitates initiation of skin immune response by regulating Langerhans cell migration and maturation.

Nature Med. 9, 744-749 2003年
Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity

Nature Immunology vol. 4, no.7,pp694-701 2003年
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

T Tsuji, T Ishizaki, M Okamoto, C Higashida, K Kimura, T Furuyashiki, Y Arakawa, RB Birge, T Nakamoto, H Hirai …

JOURNAL OF CELL BIOLOGY 157(5) 819-830 2002年5月
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts

T Tsuji, T Ishizaki, M Okamoto, C Higashida, K Kimura, T Furuyashiki, Y Arakawa, RB Birge, T Nakamoto, H Hirai …

JOURNAL OF CELL BIOLOGY 157(5) 819-830 2002年5月
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.

J. Clin. Invest. 109, 883-893. 2002年
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut.

J. Clin. Invest. 109, 883-893. 2002年
Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation.

Proc. Natl. Acad. Sci. U.S.A. 99, 4580-4585. 2002年
Stimulation of Bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation.

Proceedings of the National Academy of Sciences of U.S.A. vol.99, pp4580-4585 2002年
Coordination of microtubules and actin cytoskeleton by a Rho effector, mDia1.

Nature Cell Biol.. 3. 8-14 2001年

成宮周

基本情報

研究キーワード

研究分野

委員歴

受賞

論文

MISC

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

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