SHIMOHAMA Shun

J-GLOBAL         Last updated: Feb 1, 2015 at 17:46
 
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Name
SHIMOHAMA Shun
Affiliation
Sapporo Medical University
Section
Graduate School of Medicine
Degree
Doctor of Medicine(Kyoto University), Doctor of Medicine

Research Areas

 

Academic & Professional Experience

 
1987
 - 
1989
Postdoctoral Fellow
 

Education

 
 
 - 
1987
Graduate School, Division of Medicine, Kyoto University
 
 
 - 
1981
Faculty of Medicine, Kyoto University
 

Published Papers

 
Matsumura A, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Takata K, Kitamura Y, Shimohama S
Journal of Alzheimer's disease : JAD   44 409-423   Jan 2015   [Refereed]
Suzuki S, Kawamata J, Iwahara N, Matsumura A, Hisahara S, Matsushita T, Sasaki M, Honmou O, Shimohama S
Neuroscience letters   584 276-281   Jan 2015   [Refereed]
Niino M, Sato S, Fukazawa T, Yoshimura S, Hisahara S, Matsushita T, Isobe N, Yoshida K, Houzen H, Miyazaki Y, Shimohama S, Kikuchi S, Kira JI
Multiple sclerosis (Houndmills, Basingstoke, England)      Jan 2015   [Refereed]
Hisahara S, Matsushita T, Kitamura M, Mezawa S, Nonaka M, Imai T, Shimohama S
Journal of the neurological sciences   346 303-306   Nov 2014   [Refereed]
Jingami N, Uemura K, Noto R, Asada M, Takahashi M, Ozaki A, Kihara T, Kageyama T, Takahashi R, Shimohama S, Kinoshita A
Journal of Alzheimer's disease : JAD      Nov 2014   [Refereed]

Misc

 
Aberrant accumulation of phospholipose C-delta in Alzheimer brain
American Journal of Pathology   139(4)    1991
Grafting genetically moditied cells into the rat brain : Characteristics of E. coli β-galactosidase as a reporter gene
Molecular Brain Research   5    1989
Biochemical characterization of the nicotinic cholingergic receptors in human brain : Binding of (-)-3H-nicotine
Journal of Neurochemistry   45    1985

Books etc

 
Intracerebral grafting of genetically modified cells : application to a rat model of Parkinson's disease
Raven Press, "Advances in Neurology"   1993   
Nicotinic receptor stimulation protects neurons against glutamate-and β-amyloid-induced cytotoxicity
In"Alzheimer's Disease and Related Disorders : Etiology, Pathagenesis and therapeutitics"John Wiley & Sons, Ltd.   1999   

Works

 
Proteome analysis in Alzheimer's disease
2001

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2009 - 2011    Investigator(s): Shin HISAHARA
We now have investigating the function of histone deacetylase SIRT(sirtuin). To explore preventive effect against cell death, we have performed cell viability assay in PC12 and SHSY5Y cells with administration of hydrogen peroxide(H2O2) and 6-hydr...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2006    Investigator(s): Jun KAWAMATA
1.Establishing proteome map of nervous system of ALS transgenic mice (Gurney et al. Science 1994)We have made proteome map (soluble fraction and insoluble fraction) of nervous system of young and old ALS Tg mice.2.Analysis of therapeutic effect an...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Hideyuki SAWADA
Neurodegenerative disorders including Parkinson disease have common features, selective neuronal death and accumulation of insoluble proteins in the neurons. In Parkinson disease these two features are selective dopaminergic neuronal death and the...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2002 - 2003    Investigator(s): Hideyuki SAWADA
Parkinson's disease is characterized by dopaminergic neuronal death and the presence of Lewy bodies. α-Synuclein is a major component of Lewy bodies, but the process of its accumulation and its relationship to dopaminergic neuronal death have not ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2001 - 2002    Investigator(s): Sadaki FUJIMOTO
When oxidative stress is induced in the rat cerebral cortex through hyperoxia, the protein levels of phospholipase C (PLC)-β1 and -δ1 were significantly increased in the cerebral cortex, although that of PLC-γ1 was not altered. These results sugge...