Takano Mikihisa

J-GLOBAL         Last updated: Sep 25, 2019 at 03:40
 
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Name
Takano Mikihisa
E-mail
takanomhiroshima-u.ac.jp
Affiliation
Hiroshima University
Degree
Doctor of Pharmaceutical Sciences(Kyoto University), Master of Pharmaceutical Science(Kyoto University)
Research funding number
20211336

Research Areas

 
 

Academic & Professional Experience

 
Apr 2019
   
 
Professor, Graduate School of Biomedical & Health Sciences, Hiroshima University
 
Apr 2002
 - 
Mar 2019
Professor, Graduate School of Biomedical Sciences, Hiroshima University
 
Jun 1996
 - 
Mar 2002
Professor, Faculty of medicine, Hiroshima University
 
Feb 1995
 - 
May 1996
Associate Professor, Kyoto University Hospital
 
Mar 1991
 - 
Feb 1995
Lecturer, Kyoto University Hospital
 

Education

 
Apr 1982
 - 
Mar 1985
Graduate School, Division of Pharmaceutical Sciences, Kyoto University
 
Apr 1976
 - 
Mar 1980
Faculty of Pharmaceutical Science, Kyoto University
 

Awards & Honors

 
Nov 2015
JSSX Award 2015
Winner: Mikihisa Takano
 
Oct 2008
Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity
 

Published Papers

 
Takano, Mikihisa; Takeuchi, Tomoya; Kuriyama, Shiori; Yumoto, Ryoko
LIFE SCIENCES   229 173-179   Jul 2019   [Refereed]
Aims: The innate immune response induced by bacterial peptidoglycan peptides, such as gamma-D-glutamyl-mesodiaminopimelic acid (iE-DAP), is an important host defense system. However, little is known about the innate immune response in the lung alv...
Kawami, Masashi; Honda, Natsuko; Miyamoto, Mioka; Yumoto, Ryoko; Takano, Mikihisa
JOURNAL OF PHARMACY AND PHARMACOLOGY   71(2) 167-175   Feb 2019   [Refereed]
Objectives We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate analogue, using alveolar epithelial A549 cells. Therefore, we examined MTX uptake in NCl-H44...
Takano, M.; Higashi, M.; Ito, H.; Toyota, S.; Hirabayashi, Y.; Yumoto, R.
PHARMAZIE   73(12) 700-705   Dec 2018   [Refereed]
In human erythrocyte membranes, various influx and efflux transporters are functionally expressed. However, their transport characteristics and modulation under disease states are not fully understood. In this study, we first examined the expressi...
Kawami, Masashi; Harabayashi, Rika; Harada, Risako; Yamagami, Yohei; Yumoto, Ryoko; Takano, Mikihisa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   497(1) 457-463   2018   [Refereed]
Methotrexate (MTX) often induces serious lung diseases such as pulmonary fibrosis. Although MTX is known to be a folic acid (FA) antagonist, the effect of FA on MTX-induced lung injury remains unclear. Recent studies indicate that epithelial-mesen...
Kawami, Masashi; Shimonakamura, Tadashi; Yumoto, Ryoko; Takano, Mikihisa
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES   21 247-255   2018   [Refereed]
Purpose. Alveolar clearance of proteins, such as albumin, plays an essential role in recovery from lung injuries. Albumin is known to be oxidized by reactive oxygen species (ROS), leading to generation of advanced oxidation protein products (AOPP)...
Kawami, M.; Yamada, Y.; Issarachot, O.; Junyaprasert, V. B.; Yumato, R.; Takano, M.
PHARMAZIE   73(2) 104-109   2018   [Refereed]
The extract of Azadirachta indica, commonly known as neem, has found extensive use in traditional medicine for treating various human diseases. In this study, the effect of the 50% ethanol extract of A. indica (A101) on P-glycoprotein (P-gp)-media...
JOURNAL OF PHARMACY AND PHARMACOLOGY   in press    2018   [Refereed]
Functional expression of breast cancer resistance protein and cholesterol effect in human erythrocyte membranes
Takano, M., Higashi, M., Ito, H., Toyota, S., Hirabayashi, Y. and Yumoto, R.
PHARMAZIE   in press    2018   [Refereed]
Cobalt Chloride Induces Expression and Function of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Renal Proximal Tubular Epithelial Cell Line HK-2
Nishihashi, Katsuki; Kawashima, Kei; Nomura, Takami; Urakami-Takebayashi, Yumiko; Miyazaki, Makoto; Takano, Mikihisa; Nagai, Junya
BIOLOGICAL & PHARMACEUTICAL BULLETIN   40(1) 82-87   2017   [Refereed]
The human breast cancer resistance protein (BCRP/ABCG2), a member of the ATP-binding cassette transporter family, is a drug transporter restricting absorption and enhancing excretion of many compounds including anticancer drugs. The cis-regulatory...
Kawami, M.; Yamada, Y.; Toshimori, F.; Issarachot, O.; Junyaprasert, V. B.; Yumoto, R.; Takano, M.
PHARMAZIE   72(2) 123-127   2017   [Refereed]
Curcuma comosa has been widely used as a herbal medicine in Thailand; however, it remains unclear whether C. comosa influences the absorption of drugs that are substrates for the transporters in the small intestine. In this study, we investigated ...
Kawami, Masashi; Deguchi, Junya; Yumoto, Ryoko; Sakakibara, Norikazu; Tsukamoto, Ikuko; Konishi, Ryoji; Takano, Mikihisa
DRUG METABOLISM AND PHARMACOKINETICS   32(4) 224-227   2017   [Refereed]
Transforming growth factor (TGF)-beta 1 has received much attention as a major inducer of epithelial-mesenchymal transition (EMT) in pathological conditions such as cancer and organ fibrosis. In this study, we examined the effect of a novel nuclei...
Takano, Mikihisa; Kamei, Hidetaka; Nagahiro, Machi; Kawami, Masashi; Yumoto, Ryoko
LIFE SCIENCES   188 76-82   2017   [Refereed]
Aims: Nicotine is rapidly absorbed from the lung alveoli into systemic circulation during cigarette smoking. However, mechanism underlying nicotine transport in alveolar epithelial cells is not well understood to date. In the present study, we cha...
Ehrhardt, Carsten; Backman, Per; Couet, William; Edwards, Chris; Forbes, Ben; Friden, Markus; Gumbleton, Mark; Hosoya, Ken-Ichi; Kato, Yukio; Nakanishi, Takeo; Takano, Mikihisa; Terasaki, Tetsuya; Yumoto, Ryoko
JOURNAL OF PHARMACEUTICAL SCIENCES   106(9) 2234-2244   2017   [Refereed]
The School of Pharmacy and Pharmaceutical Sciences at Trinity College Dublin hosted the "1st Workshop on Drug Transporters in the Lungs" in September 2016 to discuss the impact of transporters on pulmonary drug disposition and their roles as drug ...
Takano, Mikihisa; Nekomoto, Chinami; Kawami, Masashi; Yumoto, Ryoko
JOURNAL OF PHARMACEUTICAL SCIENCES   106(9) 2868-2872   2017   [Refereed]
Epithelial-mesenchymal transition (EMT) of alveolar type II epithelial cells may play an important role in the pulmonary fibrosis induced by drugs such as bleomycin (BLM) and methotrexate (MTX). In this study, we examined the role of microRNAs (mi...
Takano, Mikihisa; Nagahiro, Machi; Yumoto, Ryoko
JOURNAL OF PHARMACEUTICAL SCIENCES   105(2) 982-988   2016   [Refereed]
Nicotine is absorbed from the lungs into the systemic circulation during cigarette smoking. However, there is little information concerning the transport mechanism of nicotine in alveolar epithelial cells. In this study, we characterized the uptak...
Kawami, Masashi; Harabayashi, Rika; Miyamoto, Mioka; Harada, Risako; Yumoto, Ryoko; Takano, Mikihisa
LUNG   194(6) 923-930   2016   [Refereed]
Methotrexate (MTX) therapy of certain cancers and rheumatoid arthritis often induces serious interstitial lung complications including pulmonary fibrosis. In this study, we investigated the epithelial-mesenchymal transition (EMT) induced by MTX an...
Takano M, Naka R, Sasaki Y, Nishimoto S, Yumoto R.
DRUG METABOLISM AND PHARMACOKINETICS   31(6) 417-424   2016   [Refereed]
Takano, M., Sugimoto, N., Ehrhardt, C. and Yumoto, R
PHARMACEUTICAL RESEARCH   32(12) 3916-3926   2015   [Refereed]
Development of a novel stop solution for membrane transport study
Yumoto, R., Hirabayashi, Y., Imaoka, H., Toyota, S. and Takano, M
MEMBRANE   40(5) 296-303   2015   [Refereed]
Kawami, Masashi; Miyamoto, Mioka; Yumoto, Ryoko; Takano, Mikihisa
DRUG METABOLISM AND PHARMACOKINETICS   30(4) 276-281   2015   [Refereed]
Methotrexate (MTX), a drug used for the treatment of certain cancers as well as rheumatoid arthritis, sometimes induces serious interstitial lung injury. Although lung toxicity of MTX is related to its accumulation, the information concerning MTX ...
Takano, Mikihisa;Yamamoto, Chieko;Yamaguchi, Koki;Kawami, Masashi;Yumoto, Ryoko
DRUG METABOLISM AND PHARMACOKINETICS   30(1) 111-118   2015   [Refereed]
Horibe, Sayo;Matsuda, Akira;Tanahashi, Toshihito;Inoue, Jun;Kawauchi, Shoji;Mizuno, Shigeto;Ueno, Masaki;Takahashi, Kyohei;Maeda, Yusaku;Maegouchi, Tatsuya;Murakami, Yoshiki;Yumoto, Ryoko;Nagai, Junya;Takano, Mikihisa
LIFE SCIENCES   124 31-40   2015   [Refereed]
Takano, Mikihisa;Kawami, Masashi;Aoki, Ayako;Yumoto, Ryoko
EXPERT OPINION ON DRUG DELIVERY   12(5) 813-825   2015   [Refereed][Invited]
Motonaga, Masanori; Yamamoto, Noboru; Makino, Yoshinori; Ando-Makihara, Reiko; Ohe, Yuichiro; Takano, Mikihisa; Hayashi, Yoshikazu
CANCER CHEMOTHERAPY AND PHARMACOLOGY   76(4) 713-721   2015   [Refereed]
Docetaxel and gefitinib play key roles in the treatment of non-small-cell lung cancer (NSCLC), and their combination could be of interest. Both drugs are mainly metabolized by CYP3A4, and drug-drug interactions are a major concern. This phase I do...
Takano, Mikihisa; Sugimoto, Natsumi; Ehrhardt, Carsten; Yumoto, Ryoko
PHARMACEUTICAL RESEARCH   32(12) 3916-3926   2015   [Refereed]
The peptide transporter PEPT2 is expressed in alveolar type II epithelial cells. So far, however, no appropriate alveolar epithelial cell line for studying PEPT2 function has been known. In this study, we examined the functional expression of PEPT...
Takano, M.; Kakizoe, S.; Kawami, M.; Nagai, J.; Patanasethanont, D.; Sripanidkulchai, B.; Yumoto, R.
PHARMAZIE   69(11) 823-828   2014   [Refereed]
The effects of ethanol extracts from Thai plants belonging to the families of Annonaceae, Rutaceae, and Zingiberaceae on P-glycoprotein (P-gp) function and multidrug resistance were examined in paclitaxel-resistant HepG2 (PR-HepG2) cells. All the ...
Miyagi, Toru;Shiotani, Bunsyo;Miyoshi, Ryuya;Yamamoto, Takuya;Oka, Takanori;Umezawa, Kazuo;Ochiya, Takahiro;Takano, Mikihisa;Tahara, Hidetoshi
CANCER SCIENCE   105(7) 870-874   2014   [Refereed]
Nagai, Junya;Takano, Mikihisa
BIOCHEMICAL PHARMACOLOGY   90(4) 331-337   2014   [Refereed]
Nagai, Junya;Yamamoto, Ayaka;Katagiri, Yuki;Yumoto, Ryoko;Takano, Mikihisa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   450(1) 476-481   2014   [Refereed]
Issarachot, Ousanee;Suksiriworapong, Jiraphong;Takano, Mikihisa;Yumoto, Ryoko;Junyaprasert, Varaporn Buraphacheep
JOURNAL OF NANOPARTICLE RESEARCH   16(2)    2014   [Refereed]
Population Pharmacokinetic/Pharmacodynamic Analysis of the DPP-4 Inhibitor Linagliptin in Japanese Patients with Type 2 Diabetes Mellitus
Tadayasu, Yusuke; Sarashina, Akiko; Tsuda, Yasuhiro; Tatami, Shinji; Friedrich, Christian; Retlich, Silke; Staab, Alexander; Takano, Mikihisa
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES   16(5) 708-721   2013   [Refereed]
[Objectives] Linagliptin is a novel, highly selective and long acting DPP-4 inhibitor for the treatment of type 2 diabetes mellitus (T2DM). Linagliptin exhibits non-linear pharmacokinetics (PK) due to saturable binding to plasma and tissue DPP-4. ...
Nagai, Junya;Yamamoto, Ayaka;Yumoto, Ryoko;Takano, Mikihisa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   434(3) 670-675   2013
Nagai, Junya;Komeda, Takuji;Katagiri, Yuki;Yumoto, Ryoko;Takano, Mikihisa
BIOLOGICAL & PHARMACEUTICAL BULLETIN   36(12) 1942-1949   2013
Nagai, Junya;Komeda, Takuji;Yumoto, Ryoko;Takano, Mikihisa
JOURNAL OF PHARMACY AND PHARMACOLOGY   65(3) 441-446   2013
Yumoto, Ryoko;Suzuka, Sayuri;Nishimoto, Saori;Nagai, Junya;Takano, Mikihisa
DRUG METABOLISM AND PHARMACOKINETICS   28(6) 497-503   2013
Takano, Mikihisa;Horiuchi, Taishi;Sasaki, Yoshihiro;Kato, Yuki;Nagai, Junya;Yumoto, Ryoko
LIFE SCIENCES   93(17) 630-636   2013
Yumoto, Ryoko;Kakizoe, Saki;Nagai, Junya;Patanasethanont, Denpong;Sripanidkulchai, Bung-Orn;Takano, Mikihisa
DRUG METABOLISM AND PHARMACOKINETICS   28(2) 159-163   2013
Sogame, Yoshihisa;Kitamura, Atsushi;Yabuki, Masashi;Komuro, Setsuko;Takano, Mikihisa
BIOMEDICINE & PHARMACOTHERAPY   67(5) 425-430   2013
Fukano, Yasufumi;Tsuyama, Naohiro;Mizuno, Hajime;Date, Sachiko;Takano, Mikihisa;Masujima, Tsutomu
NANOMEDICINE   7(9) 1365-1374   2012
Takano, Mikihisa;Horiuchi, Taishi;Nagai, Junya;Yumoto, Ryoko
LUNG   190(6) 651-659   2012
Yumoto, Ryoko;Suzuka, Sayuri;Oda, Keisuke;Nagai, Junya;Takano, Mikihisa
DRUG METABOLISM AND PHARMACOKINETICS   27(3) 336-343   2012
Oda, Keisuke;Yumoto, Ryoko;Nagai, Junya;Katayama, Hirokazu;Takano, Mikihisa
DRUG METABOLISM AND PHARMACOKINETICS   27(6) 570-578   2012
Sawada Takeshi;Nagai Junya;Okada Yumi;Yumoto Ryoko;Takano Mikihisa
European Journal of Pharmacology   684(1) 146-153   2012
Tanaka, Yusuke;Inkyo, Mitsugi;Yumoto, Ryoko;Nagai, Junya;Takano, Mikihisa;Nagata, Shunji
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY   38(8) 1015-1023   2012
Takano, Mikihisa;Sambuichi, Keisuke;Yamamoto, Chieko;Oda, Keisuke;Nagai, Junya;Yumoto, Ryoko
DRUG METABOLISM REVIEWS   44 90-90   2012
TAKANO Mikihisa;YUMOTO Ryoko
MEMBRANE   36(4) 145-153   Jul 2011
The lung is expected as a promising administration route for protein and peptide drugs. However, information concerning alveolar absorption mechanisms of these high molecular weight drugs is lacking. The alveolar region of the lung is lined with a...
Nagai, Junya; Sato, Koya; Yumoto, Ryoko; Takano, Mikihisa
DRUG METABOLISM AND PHARMACOKINETICS   26(5) 474-485   2011   [Refereed]
In this paper, we characterize the uptake mechanism of fluorescein isothiocyanate-labeled human immunoglobulin G (FITC-hIgG) in opossum kidney (OK) epithelial cells, which have been shown to express megalin and cubilin. Confocal immunofluorescence...
Horibe, Sayo;Nagai, Junya;Yumoto, Ryoko;Tawa, Riichi;Takano, Mikihisa
JOURNAL OF PHARMACEUTICAL SCIENCES   100(7) 3010-3017   2011
Oda, Keisuke;Yumoto, Ryoko;Nagai, Junya;Katayama, Hirokazu;Takano, Mikihisa
EUROPEAN JOURNAL OF PHARMACOLOGY   672(1-3) 62-69   2011
YUMOTO Ryoko;KIMURA Eri;SUZUKI Satoshi;IMAOKA Hiroaki;NAGAI Junya;TAKANO Mikihisa
Membrane   35(6) 297-304   Nov 2010
TAKANO Mikihisa;KIMURA Eri;SUZUKI Satoshi;NAGAI Junya;YUMOTO Ryoko
25(4) 351-360   Aug 2010
Effect of Thai Plant Extracts on P-glycoprotein Function and Viability in Paclitaxel-Resistant HepG2 Cells
Kawami, Masashi; Yumoto, Ryoko; Nagai, Junya; Junyaprasert, Varaporn Buraphacheep; Soonthornchareonnon, Noppamas; Patanasethanont, Denpong; Sripanidkulchai, Bung-orn; Takano, Mikihisa
DRUG METABOLISM AND PHARMACOKINETICS   25(2) 155-162   2010   [Refereed]
The effects of ethanol extracts from Thai plants on P-glycoprotein (P-gp) function and cell viability were examined using paclitaxel-resistant HepG2 (PR-HepG2) cells KP018 from Ellipeiopsis cherrevensis and AT80 from Ancistrocladus tectorius incre...
Tanaka, Yusuke;Inkyo, Mitsugi;Yumoto, Ryoko;Nagai, Junya;Takano, Mikihisa;Nagata, Shunji
CURRENT NANOSCIENCE   6(6) 571-576   2010
Ishikawa, Yuka;Nagai, Junya;Okada, Yumi;Sato, Koya;Yumoto, Ryoko;Takano, Mikihisa
BIOLOGICAL & PHARMACEUTICAL BULLETIN   33(3) 504-511   2010
Takano, Mikihisa;Suzuki, Satoshi;Imaoka, Hiroaki;Nagai, Junya;Yumoto, Ryoko
DRUG METABOLISM REVIEWS   42 294-295   2010
Nagai, Junya;Takano, Mikihisa
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY   6(9) 1125-1138   2010
Katsube, Takayuki;Yano, Yoshitaka;Wajima, Toshihiro;Yamano, Yoshinori;Takano, Mikihisa
JOURNAL OF PHARMACEUTICAL SCIENCES   99(5) 2483-2491   2010
Kawami Masashi;Yumoto Ryouko;Suzuka Sayuri;Nagai Junya;Junyaprasert Varaporn;Soonthornchareonnon Noppamas;Patanasethanont Denpong;Sripanidkulchai Bung-orn;Takano Mikihisa
Abstracts of JSSX meeting   25 146-146   2010
Sato Koya;Nagai Junya;Yumoto Ryoko;Takano Mikihisa
Abstracts of JSSX meeting   25(0) 82-82   2010
Sato Koya;Nagai Junya;Mitsui Naoko;Yumoto Ryoko;Takano Mikihisa
Life Sciences   85(23) 800-807   Dec 2009
TAKANO Mikihisa;OTANI Yoshifumi;TANDA Minori;KAWAMI Masashi;NAGAI Junya;YUMOTO Ryoko
Drug Metab. Pharmacokinet.   24(5) 418-427   Oct 2009
Effect of ursodeoxycholic acid treatment on the expression and function of multidrug resistance-associated protein 2 in rat intestine.
J. Pharm. Sci.   98(8) 2822-2831   Aug 2009   [Refereed]
YUMOTO Ryoko;YAMAKAWA Keiko;NAGAI Junya;TAKANO Mikihisa
Membrane   34(3) 152-158   May 2009
Paclitaxel-resistance Conferred by Altered Expression of Efflux and Influx Transporters for Paclitaxel in the Human Hepatoma Cell Line, HepG2
Takano, Mikihisa; Otani, Yoshifumi; Tanda, Minori; Kawami, Masashi; Nagai, Junya; Yumoto, Ryoko
DRUG METABOLISM AND PHARMACOKINETICS   24(5) 418-427   2009   [Refereed]
Paclitaxel-resistant HepG2 (PR-HepG2) cells were established by long-term exposure of HepG2 cells to paclitaxel and expression and function of efflux (P-glycoprotein, MRP2) and influx (OATP1B3) transporters for paclitaxel were examined to understa...
Fujii, Kenji;Nagai, Junya;Sawada, Takeshi;Yumoto, Ryoko;Takano, Mikihisa
BIOCONJUGATE CHEMISTRY   20(8) 1553-1558   2009
Yumoto, Ryoko;Kawami, Masashi;Nagai, Junya;Patanasethanont, Denpong;Sripanidkulchai, Bung-orn;Junyaprasert, Varaporn;Soonthornchareonnon, Noppamas;Takano, Mikihisa
DRUG METABOLISM REVIEWS   41 62-62   2009
Ikehata, Mika;Yumoto, Ryoko;Kato, Yuki;Nagai, Junya;Takano, Mikihisa
BIOLOGICAL & PHARMACEUTICAL BULLETIN   32(10) 1765-1769   2009
Tanaka, Yusuke;Inkyo, Mitsugi;Yumoto, Ryoko;Nagai, Junya;Takano, Mikihisa;Nagata, Shunji
CHEMICAL & PHARMACEUTICAL BULLETIN   57(10) 1050-1057   2009
Nagai Junya;Sawada Takeshi;Fujii Kenji;Yumoto Ryouko;Takano Mikihisa
Abstracts of JSSX meeting   24 158-158   2009
Sato Koya;Nagai Junya;Mitsui Naoko;Yumoto Ryoko;Takano Mikihisa
Abstracts of JSSX meeting   24 164-164   2009
Tanaka Yusuke;Inkyo Mitsugi;Yumoto Ryoko;Nagai Junya;Takano Mikihisa;Nagata Shunji
Abstracts of JSSX meeting   24 249-249   2009
Yumoto Ryoko;Tagawa Maki;Nagai Junya;Sakai Masahiko;Kuwata Naoharu;Kihira Kenji;Ishino Takashi;Hirakawa Katsuhiro;Takano Mikihisa
Japanese journal of pharmaceutical health care and sciences   34(10) 951-955   Oct 2008
Burow's solution, a hospital preparation, exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and other microorganisms that are commonly observed in chronic supprative otitis media. However, it takes several ...
Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents.
Antimicrob. Agents Chemother.   52(9) 3229-3236   Sep 2008   [Refereed]
Cell technology.   27(8) 790-795   Aug 2008
Transport of prostaglandin E1 across rat erythrocyte membrane.
Biol Pharm Bull   31(6) 1288-1291   Jun 2008   [Refereed]
TAOGOSHI Takanori;NAGAI Junya;YUMOTO Ryoko;TAKANO Mikihisa
Biological & pharmaceutical bulletin   31(6) 1288-1291   Jun 2008
In this study erythrocyte transport of prostaglandin E_1 (PGE_1) was investigated by employing inside-out membrane vesicles prepared from rat erythrocytes. The uptake of [^3H]PGE_1 in the presence of ATP was significantly higher than that of AMP, ...
TAKANO Mikihisa
Drug Metabolism and Pharmacokinetics   23(2) 85-86   Apr 2008
Comparison of albumin uptake in rat alveolar type II and type I-like epithelial cells in primary culture.
Pharm. Res.   25(4) 913-922   Apr 2008   [Refereed]
Mizuno, Hajime; Tsuyama, Naohiro; Harada, Takanori; Masujima, Tsutomu
JOURNAL OF MASS SPECTROMETRY   43(12) 1692-1700   2008   [Refereed]
The molecular content from the cytoplasm of a live, single mammalian cell and its organelle were trapped with a nano-electrospray ionization (ESI) tip acting as a micropipette under a video microscope, and hundreds of small molecular peaks were de...
Murakami, Teruo;Takano, Mikihisa
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY   4(7) 923-939   2008
Tagawa, Maki;Yumoto, Ryoko;Oda, Keisuke;Nagai, Junya;Takano, Mikihisa
DRUG METABOLISM AND PHARMACOKINETICS   23(5) 318-327   2008
Katsube, Takayuki;Yano, Yoshitaka;Yamano, Yoshinori;Munekage, Tadashi;Kuroda, Naomi;Takano, Mikihisa
JOURNAL OF PHARMACEUTICAL SCIENCES   97(9) 4108-4117   2008
Katsube, Takayuki;Yano, Yoshitaka;Yamano, Yoshinori;Takano, Mikihisa
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   128 78-78   2008
Hanada, Yukako;Kimura, Eri;Nagai, Junya;Yumoto, Ryoko;Takano, Mikihisa
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   128 79-79   2008
Ikehata Mika;Yumoto Ryoko;Kato Yuki;Nagai Junya;Takano Mikihisa
Abstracts of JSSX meeting   23 128-128   2008
Fukuda Takeshi;Nunoya Ken-ichi;Kondo Tetsu;Umemura Takeo;Yamazaki Yoshiyuki;Matsumoto Ichiro;Miyata Yasuyuki;Ogawa Mikio;Yumoto Ryoko;Takano Mikihisa
Abstracts of JSSX meeting   23 212-212   2008
Oda Keisuke;Yumoto Ryouko;Nagai Junya;Katayama Hirokazu;Takano Mikihisa
Abstracts of JSSX meeting   23 182-182   2008
Ishikawa Yuka;Nagai Junya;Yumoto Ryoko;Takano Mikihisa
Abstracts of JSSX meeting   23 113-113   2008
Role of intestinal efflux transporters in the intestinal absorption of methotrexate in rats.
J Pharm Pharmacol   59(9) 1263-1270   Sep 2007   [Refereed]
Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components.
Eur J Pharmacol   566(1-3) 67-74   Jul 2007   [Refereed]
Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells.
J Pharm Pharmacol   59(4) 513-520   Apr 2007   [Refereed]
Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function.
J Pharm Sci   96(1) 223-233   Jan 2007   [Refereed]
Tagawa, Maki;Yumoto, Ryoko;Oda, Keisuke;Katayama, Hirokazu;Murakami, Teruo;Nagai, Junya;Takano, Mikihisa
DRUG METABOLISM REVIEWS   39 162-163   2007
Nagai, Junya;Mitsui, Naoko;Yumoto, Ryoko;Takano, Mikihisa
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   127 165-166   2007
Yumoto Ryoko;Nishikawa Hiromi;Okamoto Miho;Katayama Hirokazu;Nagai Junya;Takano Mikihisa
Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University   25 93-94   2007

Conference Activities & Talks

 
In vitro study on secreted factors associated with drug-induced epithelial-mesenchymal transition in A549 cells
Masashi Kawami, Yohei Yamagami, Risako Harada, Takamichi Ojima, Ryoko Yumoto, Mikihisa Takano
The 1st Workshop of The Research Center for Drug Development and Biomarker Discovery   2 Mar 2019   
Role of transporters related to metabolic changes during epithelial-mesenchymal transition in human alveolar epithelial cell line A549
Mohi Uddin, Ryoko Yumoto, Masashi Kawami, Mikihisa Takano
2018 International Meeting on 22nd MDO and 33rd JSSX   4 Oct 2018   
Role of plasminogen activator inhibitor-1 in methotrexate-induced epithelial-mesenchymal transition in cultured human alveolar epithelial A549 cells
Yohei Yamagami, Ryoko Yumoto, Masashi Kawami, Mikihisa Takano
2018 International Meeting on 22nd MDO and 33rd JSSX   4 Oct 2018   
Search for the compound preventing drug-induced epithelial-mesenchymal transition and its mechanism in alveolar epithelial RLE/Abca3 cells
Shunsuke Senoh, Junya Deguchi, Ryoko Yumoto, Mikihisa Takano
2018 International Meeting on 22nd MDO and 33rd JSSX   4 Oct 2018   
Role of membrane cholesterol in the functions of influx and efflux transporters in human erythrocytes
Makoto Higashi, Hiroki Ito, Ryoko Yumoto, Mikihisa Takano
2018 International Meeting on 22nd MDO and 33rd JSSX   4 Oct 2018   

Research Grants & Projects

 
JSPS: KAKENHI(Grant-in-Aid for Scientific Research (B))
Project Year: 2018 - 2021
Project Year: 2014 - 2016
Project Year: 2014 - 2017
MEXT: KAKENHI
Project Year: 2011 - 2013    Investigator(s): TAKANO, Mikihisa
Low temperature tolerance of membrane transporters, a characteristic showing transport activity even at ice-cold temperature, was examined in human erythrocytes and cultured cancer cells. A facilitative glucose transporter GLUT1 and a facilitative...
Project Year: 2011 - 2014