論文

査読有り
2009年9月

Development of a conjugated gadolinium and cisplatin-gelatin possessing properties as an intravascular contrast agent for MR imaging

EUROPEAN JOURNAL OF RADIOLOGY
  • Akinaga Sonoda
  • ,
  • Norihisa Nitta
  • ,
  • Shinichi Ohta
  • ,
  • Ayumi Seko
  • ,
  • Jun-ichiro Jo
  • ,
  • Shigehiro Morikawa
  • ,
  • Yasuhiko Tabata
  • ,
  • Masashi Takahashi
  • ,
  • Kiyoshi Murata

71
3
開始ページ
570
終了ページ
575
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ejrad.2008.04.009
出版者・発行元
ELSEVIER IRELAND LTD

Purpose: The purpose of this study is to create a Gd-DTPA-Gel-Cis compound, which made from gadolinum (Gd), diethylenetriaminepentaacetic acid (DTPA)-dianhydride, cis-diamminedichloroplatinum (Cis) and bovine gelatin (Gel), that makes it possible to visualize Cis as intravascular agent under magnetic resonance imaging (MRI).
Materials and methods: The amount of DTPA, Gd, and Cis were titrated to determine the new compound's conjugation ratio with gelatin. Considering these functions, Gd-DTPA-Gel-Cis was synthesized, and its stability in bovine serum was evaluated. In addition, the signal intensity of the diluted sample was measured under 1.5 Tesla MRI.
Results: The synthesized 10 mg/ml of Gd-DTPA-Gel-Cis contained 42.84 mu g/ml of Gd and 1.53 mu g/ml of platinum. Gd-DTPA-Gel-Cis (100 mg/10 ml) enclosed into the cellulose dialysis tubing was placed in 90 ml of bovine serum and shaken reciprocally at 72 stroke/min at 37 degrees C. Partial release of free Pt was shown at 6 and 24 h, but no release of Gd occurred for a 24-h period. And high stability of Gd conjugated to DTPA-Gel-Cis. This result suggests possible anti-tumor effectiveness and high stability of Gd conjugated to DTPA-Gel-Cis. The diluted sample presented high signal intensity under 1.5 Tesla MRI.
Conclusion: Gd-DTPA-Gel-Cis has been developed successfully and we have proven its stability and contrast ability in MRI. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.ejrad.2008.04.009
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000270644400028&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.ejrad.2008.04.009
  • ISSN : 0720-048X
  • Web of Science ID : WOS:000270644400028

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