2015年12月
Technical Report: Correlation Between the Repair of Cartilage and Subchondral Bone in an Osteochondral Defect Using Bilayered, Biodegradable Hydrogel Composites
TISSUE ENGINEERING PART C-METHODS
- 巻
- 21
- 号
- 12
- 開始ページ
- 1216
- 終了ページ
- 1225
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1089/ten.tec.2015.0117
- 出版者・発行元
- MARY ANN LIEBERT, INC
The present work investigated correlations between cartilage and subchondral bone repair, facilitated by a growth factor-delivering scaffold, in a rabbit osteochondral defect model. Histological scoring indices and microcomputed tomography morphological parameters were used to evaluate cartilage and bone repair, respectively, at 6 and 12 weeks. Correlation analysis revealed significant associations between specific cartilage indices and subchondral bone parameters that varied with location in the defect (cortical vs. trabecular region), time point (6 vs. 12 weeks), and experimental group (insulin-like growth factor-1 only, bone morphogenetic protein-2 only, or both growth factors). In particular, significant correlations consistently existed between cartilage surface regularity and bone quantity parameters. Overall, correlation analysis between cartilage and bone repair provided a fuller understanding of osteochondral repair and can help drive informed studies for future osteochondral regeneration strategies.
- リンク情報
- ID情報
-
- DOI : 10.1089/ten.tec.2015.0117
- ISSN : 1937-3384
- eISSN : 1937-3392
- Web of Science ID : WOS:000365530000002