2012年5月
Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm
NATURE COMMUNICATIONS
- 巻
- 3
- 号
- 開始ページ
- 809
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ncomms1812
- 出版者・発行元
- NATURE PUBLISHING GROUP
Nocturnal enuresis in children and nocturia in the elderly are two highly prevalent clinical conditions characterized by a mismatch between urine production rate in the kidneys and storage in the urinary bladder during the sleep phase. Here we demonstrate, using a novel method for automated recording of mouse micturition, that connexin43, a bladder gap junction protein, is a negative regulator of functional bladder capacity. Bladder connexin43 levels and functional capacity show circadian oscillations in wild-type mice, but such rhythms are completely lost in Cry-null mice having a dysfunctional biological clock. Bladder muscle cells have an internal clock, and show oscillations of connexin43 and gap junction function. A clock regulator, Reverb alpha, upregulates connexin43 transcription as a cofactor of Sp1, using Sp1 cis-elements of the promoter. Therefore, circadian oscillation of connexin43 is associated with the biological clock and contributes to diurnal changes in bladder capacity, which avoids disturbance of sleep by micturition.
- リンク情報
- ID情報
-
- DOI : 10.1038/ncomms1812
- ISSN : 2041-1723
- Web of Science ID : WOS:000304611400009