2008年10月
Bone Regeneration Using Titanium Nonwoven Fabrics Combined with FGF-2 Release from Gelatin Hydrogel Microspheres in Rabbit Skull Defects
TISSUE ENGINEERING PART A
- ,
- ,
- 巻
- 14
- 号
- 10
- 開始ページ
- 1663
- 終了ページ
- 1671
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1089/ten.tea.2006.0350
- 出版者・発行元
- MARY ANN LIEBERT INC
The objective of this study was to modify titanium nonwoven fabrics (Ti) with a hydroxyapatite (HA)-like coating and fibroblast growth factor (FGF)-2 combination, and evaluate the bone regeneration potential of the modified Ti. Biodegradable gelatin hydrogel microspheres (GM) were prepared as a carrier matrix for the controlled release of FGF-2. Ti, HA-coated Ti (Ti-HA), and Ti-HA incorporating GM (Ti-HA-GM) infused FGF-2 were applied to skull defects of rabbits. Then osteointegration in the Ti was evaluated by alkaline phosphatase activity, Ca2+ content, and histological observation, and the hemoglobin content was assessed for angiogenic measurement. Ti-HA-GM promoted bone regeneration to a significantly greater extent than Ti, Ti-HA, or mixed Ti-HA and free FGF-2 6 weeks after application, and it also enhanced the hemoglobin content. It is concluded that the combination of HA- like coating and FGF-2 release promotes Ti induction of bone regeneration.
- リンク情報
- ID情報
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- DOI : 10.1089/ten.tea.2006.0350
- ISSN : 1937-3341
- Web of Science ID : WOS:000259998000008