2015年1月
Sequential Synthesis of Coordination Polymersomes
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- 巻
- 54
- 号
- 4
- 開始ページ
- 1139
- 終了ページ
- 1143
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/anie.201408101
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Novel organic-inorganic hybrid liposomes, so-called coordination polymersomes (CPsomes), with artificial domains that exhibit strong lateral cohesion were prepared by a three-step procedure that formed a coordinative interaction leading to a lipid bilayer. First, the lipophilic complex (dabco-C-18)[Mn(N)(CN)(4)(dabco-C-18)] (1; dabco-C-18(+)=1,4-diazabicyclo[2,2,2]octane-(CH2)(17)CH3 cation), was synthesized. 1 has a lipophilic alkyl tail part and a tetracyanometallate head group, which can be used for an expansion to two-dimensional coordination networks. Second, 1 and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine were mixed to prepare the liposomes. Finally, CPsomes were obtained by the addition of transition-metal ions (M) to form unilamellar faceted liposomes with plain CP raft domains with MnCNM linkages. The concentration of 1 influences the size of the CP raft domains and the shape of the CPsomes. The synthesis of coordination polymers in lipid bilayers is a novel approach for the construction of artificial architectures as raft domains, for example, in cell membranes.
- リンク情報
- ID情報
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- DOI : 10.1002/anie.201408101
- ISSN : 1433-7851
- eISSN : 1521-3773
- Web of Science ID : WOS:000348372900009