論文

査読有り 国際誌
2017年8月

SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions.

Neuropathology : official journal of the Japanese Society of Neuropathology
  • Ichiro Akiguchi
  • ,
  • Mercè Pallàs
  • ,
  • Herbert Budka
  • ,
  • Haruhiko Akiyama
  • ,
  • Masaki Ueno
  • ,
  • Jingxian Han
  • ,
  • Hideo Yagi
  • ,
  • Tomohumi Nishikawa
  • ,
  • Yoichi Chiba
  • ,
  • Hiroshi Sugiyama
  • ,
  • Ryoya Takahashi
  • ,
  • Keiko Unno
  • ,
  • Keiichi Higuchi
  • ,
  • Masanori Hosokawa

37
4
開始ページ
293
終了ページ
305
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/neup.12373

Senescence accelerated mice P8 (SAMP8) show significant age-related deteriorations in memory and learning ability in accordance with early onset and rapid advancement of senescence. Brains of SAMP8 mice reveal an age-associated increase of PAS-positive granular structures in the hippocampal formation and astrogliosis in the brain stem and hippocampus. A spongy degeneration in the brain stem appears at 1 month of age and reaches a maximum at 4-8 months. In addition, clusters of activated microglia also appear around the vacuoles in the brain stem. β/A4(Aβ) protein-like immunoreactive granular structures are observed in various regions and increase in number markedly with age. Other age-associated histological changes include cortical atrophy, neuronal cell loss in locus coeruleus and lateral tegmental nuclei, intraneuronal accumulation of lipopigments in Purkinje cells and eosinophilic inclusion bodies in thalamic neurons. A blood-brain barrier dysfunction and astrogliosis are also prominent with advancing age in the hippocampus. These changes are generally similar to the pathomorphology of aging human brains and characterized by their association with some specific glioneuronal reactions. As for the hallmarks of Alzheimer brains, tau morphology has not yet been confirmed regardless of the age-related increase in phosphorylated tau in SAMP8 mice brains, but early age-related Aβ deposition in the hippocampus has recently been published. SAMP8 mice are, therefore, not only a senescence-accelerated model but also a promising model for Alzheimer's disease and other cognitive disorders.

リンク情報
DOI
https://doi.org/10.1111/neup.12373
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28261874
ID情報
  • DOI : 10.1111/neup.12373
  • PubMed ID : 28261874

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