永田和宏 (NAGATA KAZUHIRO) - マイポータル - researchmap

基本情報

学位: 理学博士

J-GLOBAL ID: 200901074469277498
researchmap会員ID: 1000027288

外部リンク: http://www.cc.kyoto-su.ac.jp/~nagata/index-j.html

研究キーワード

2

研究分野

2

学歴

1

- 1971年

京都大学

MISC

96

Insufficient folding of type IV collagen and formation of abnormal basement membrane-like structure in embryoid bodies derived from Hsp47-null embryonic stem cells

Y Matsuoka, H Kubota, E Adachi, N Nagai, T Marutani, N Hosokawa, K Nagata

MOLECULAR BIOLOGY OF THE CELL 15(10) 4467-4475 2004年10月
Accumulation of type IV collagen in dilated endoplasmic reticulum leads to apoptosis in HSP47-knockout mouse embryos through the induction of CHOP. T. MARUTANI, A. YAMAMOTO, N. NAGAI, H. KUBOTA & K. NAGATA

J. Cell. Sci 117:5913-5922/, 2004年
Characterization of multiple members of the HSP70 family in playfish culture cells:molecular evolution of stress protein HSP70 in vertebrates. M. YAMASHITA, K. HIRAYOSHI & K. NAGATA

Gene 336:207-218/, 2004年
Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy. S. OHASHI, H. ABE, T. TAKAHASHI, Y. YAMAMOTO, M. TAKEUCHI, H. ARAI, K. NAGATA, T. KITA, H. OKAMOTO, H. YAMAMOTO, T. DOI

J. Biol. Chem 279(19):19816-19823/, 2004年
The endoplasmic reticulum stress response in stimulated through the continuous activation of transcription factors ATF6 and XBP1 in ins2^+/Akita pancreatic β cells. J. NOZAKI, H. KUBOTA, H. YOSHIDA, M. NAITOH, J. GOJO, T. YOSHINAGA, K.・・・

Genes Cells 9:261-270/, 2004年
HSP47 as a collagen-specific molecular chaperone: function and expression in normal mouse development

K Nagata

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY 14(5) 275-282 2003年10月
Transcriptional regulation of the cytosolic chaperonin theta subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and net in the absence of serum response factor

Y Yamazaki, H Kubota, M Nozaki, K Nagata

JOURNAL OF BIOLOGICAL CHEMISTRY 278(33) 30642-30651 2003年8月
Enhancement of endoplasmic reticulum(ER) degradation of misfolded null Hong Kong α 1-antitrypsin by human ER mannosidase I. N. HOSOKAWA, L. O. TREMBLAY, Z. YOU, A. HERSCOVICS, I, WADA & K. NAGATA

J. Biol. Chem. 278/28, 26287-26294 2003年
Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease. S. YOKOTA, H. KUBOTA, Y.MATSUOKA, M. NAITOH, D. HIRATA, S.MINOTA, H. TAKAHASHI, N. FUJII & K. NAGATA

Biochem Biophys Res Commun. 303/, 413-418 2003年
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin. Y. ODA, N. HOSOKAWA, I. WADA & K. NAGATA

Science 299/5611, 1394-1397 2003年
A. time-dependent phase shift in the mammalian unfolded proten response. H. YOSHIDA, T. MATSUI, N. HOSOKAWA, R. J. KAUFMAN, K. NAGATA & K. MORI

Develop. Cell. 4/2, 265-271 2003年
Dual-site recognition of different extracellular matrix components by anti-angiogenic / neurotrophic serpin, PEDF. N. YASUI, T. MORI, D. MORITO, O. MATSUSHITA, H. KOURAI, K. NAGATA, T. KOIDE

Biochemistry 42/11, 3160-3167 2003年
The Kruppel-like factor Zf9 and proteins in the Sp1 family regulate the expression of HSP47, a collagen-specific molecular chaperone

K Yasuda, K Hirayoshi, H Hirata, H Kubota, N Hosokawa, K Nagata

JOURNAL OF BIOLOGICAL CHEMISTRY 277(47) 44613-44622 2002年11月
Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary

K Sato, K Yomogida, T Wada, T Yorihuzi, Y Nishimune, N Hosokawa, K Nagata

JOURNAL OF BIOLOGICAL CHEMISTRY 277(40) 37678-37684 2002年10月
Increased preload directly induces the activation of heat shock transcription factor 1 in the left ventricular overloaded heart

J Nishizawa, A Nakai, M Komeda, T Ban, K Nagata

CARDIOVASCULAR RESEARCH 55(2) 341-348 2002年8月
Xaa-Arg-Gly triplets in the collagen triple helix are dominant binding sites for the molecular chaperone HSP47

T Koide, Y Takahara, S Asada, K Nagata

JOURNAL OF BIOLOGICAL CHEMISTRY 277(8) 6178-6182 2002年2月
α-mannosidese-like protein involved in quality control in the endoplasmic reticulum(ER)

Glycoforum website "Beyond glycogens" (Ed. N. Taniguchi) Seikagaku Corporation, 6/, 2002年
Mnl1p, an α-mannosidase-like protein in yeast Saccaromyces cerevisiae, is required for ER associated degradation of glycoproteins.

J. Biol. Chem. 276/12,8635-8638 2001年
A novel ER α-mannosidase-like protein accelerates ER-associated degradation.

EMBO Reports 2/5,415-422 2001年
Upregulation of HSP47 and collagen type (]G0003[) in the dermal fibrotic desease, keloid

Biochem Biophys Res Commun. 280/,1316-1322 2001年

もっとみる

書籍等出版物

96

Accumulation of type IV collagen in dilated endoplasmic reticulum leads to apoptosis in HSP47-knockout mouse embryos through the induction of CHOP. T. MARUTANI, A. YAMAMOTO, N. NAGAI, H. KUBOTA & K. NAGATA

J. Cell. Sci 2004年
Insufficient folding of type IV collagen nad formation of abnormal basement membrane-like structurein embryoid bodies derived from HSP47-null ES cells. Y. MATSUOKA, H. KUBOTA, E. ADACHI, N. NAGAI, T. MARUTANI, N. HOSOKAWA & K. NAGATA

Mol. Biol. cell 2004年
Characterization of multiple members of the HSP70 family in playfish culture cells:molecular evolution of stress protein HSP70 in vertebrates. M. YAMASHITA, K. HIRAYOSHI & K. NAGATA

Gene 2004年
Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy. S. OHASHI, H. ABE, T. TAKAHASHI, Y. YAMAMOTO, M. TAKEUCHI, H. ARAI, K. NAGATA, T. KITA, H. OKAMOTO, H. YAMAMOTO, T. DOI

J. Biol. Chem 2004年
The endoplasmic reticulum stress response in stimulated through the continuous activation of transcription factors ATF6 and XBP1 in ins2^+/Akita pancreatic β cells. J. NOZAKI, H. KUBOTA, H. YOSHIDA, M. NAITOH, J. GOJO, T. YOSHINAGA, K.・・・

Genes Cells 2004年
HSP47 as a collagen-specific molecular chaperone:function and expression in normal mouse development. K. NAGATA

Seminars in Cell and Developmental Biology 2003年
Transcriptional regulation of the cytosolic chaperonin θ subunit gene, Cctq, by Ets domain transcription factors Elk-1, Sap-1a, and net in the absence of serum response factor. Y. YAMAZAKI, H. KUBOTA, M. NOZAKI & K. NAGATA

J. Biol. Chem. 2003年
Enhancement of endoplasmic reticulum(ER) degradation of misfolded null Hong Kong α 1-antitrypsin by human ER mannosidase I. N. HOSOKAWA, L. O. TREMBLAY, Z. YOU, A. HERSCOVICS, I, WADA & K. NAGATA

J. Biol. Chem. 2003年
Prevalence of HSP47 antigen and autoantibodies to HSP47 in the sera of patients with mixed connective tissue disease. S. YOKOTA, H. KUBOTA, Y.MATSUOKA, M. NAITOH, D. HIRATA, S.MINOTA, H. TAKAHASHI, N. FUJII & K. NAGATA

Biochem Biophys Res Commun. 2003年
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin. Y. ODA, N. HOSOKAWA, I. WADA & K. NAGATA

Science 2003年
A. time-dependent phase shift in the mammalian unfolded proten response. H. YOSHIDA, T. MATSUI, N. HOSOKAWA, R. J. KAUFMAN, K. NAGATA & K. MORI

Develop. Cell. 2003年
Dual-site recognition of different extracellular matrix components by anti-angiogenic / neurotrophic serpin, PEDF. N. YASUI, T. MORI, D. MORITO, O. MATSUSHITA, H. KOURAI, K. NAGATA, T. KOIDE

Biochemistry 2003年
The Kruppel-like factor Zf9 and proteins in the Sp1 family regulate the expression of HSP47, a collagen-specific molecular chaperone.

J Biol Chem. 2002年
Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary.

J Biol Chem. 2002年
α-mannosidese-like protein involved in quality control in the endoplasmic reticulum(ER)

Glycoforum website "Beyond glycogens" (Ed. N. Taniguchi) 2002年
Increased preload directly induces the activation of heat shock transcrition factor 1 in theleft ventricular overloaed heart.

Cardiovascular Research 2002年
Xaa-Arg-Gly triplets in collagen triple-helix are dominant binding sites for the molecular chaperone HSP47.

J. Biol. Chem. 2002年
Mnl1p, an α-mannosidase-like protein in yeast Saccaromyces cerevisiae, is required for ER associated degradation of glycoproteins.

J. Biol. Chem. 2001年
A novel ER α-mannosidase-like protein accelerates ER-associated degradation.

EMBO Reports 2001年
Upregulation of HSP47 and collagen type (]G0003[) in the dermal fibrotic desease, keloid

Biochem Biophys Res Commun. 2001年

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共同研究・競争的資金等の研究課題

6