西本清一 (Sei-ichi NISHIMOTO) - マイポータル - researchmap

基本情報

所属: 京都大学大学院工学研究科物質エネルギー化学専攻基礎物質化学講座励起物質化学分野教授

学位: 工学博士

J-GLOBAL ID: 200901051732504186
researchmap会員ID: 1000027695

外部リンク: http://www.ehcc.kyoto-u.ac.jp/eh32/home/web-content/index-j.htm

研究キーワード

6

研究分野

6

委員歴

1

1998年 - 2006年

マテリアルライフ学会, 理事

MISC

79

Propargylic sulfones possessing a 2-nitroimidazole function: novel hypoxic-cell radiosensitizers with intracellular non-protein thiol depletion ability

K Tanabe, R Kojima, H Hatta, S Nishimoto

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 14(10) 2633-2635 2004年5月
Selective Neurite Outgrouth on Silver Negative Ion (Ag-)-Implanted Polystyrene Surfaces.

Chinese Journal of Polymer Science 22, 69-75 2004年
Synthesis and Cytotoxicity of Enediyne Prodrugs with 3-Hydroxy-4-(arylmethylidene)cyclodeca-1,5-diyne Scaffolds.

Letters in Drug Design & Discovery 1, 69-72 2004年
In Vitro and In Vivo Evaluation of Novel Antitumor Prodrugs of 5-Fluoro-2'-deoxyuridine Activated by Hypoxic Irradiation.

International Journal of Radiation Oncology, Biology, Physics 58, 397-402 2004年
Drug Release from Functionalized Oligodeoxynucleotide by Photo-Induced Electron Transfer.

Nucleic Acids Research, Supplement 48, 79-80 2004年
The Effect of Triple Helix Forming on Charge Transport in DNA.

Nucleic Acids Research, Supplement 48, 241-242 2004年
Photo-induced DNA cleavage reaction characteristics of propargylic sulfones possessing anthraquinone chromophore

K Haruna, K Tanabe, A Ishii, MD Wei, H Hatta, S Nishimoto

BIOORGANIC & MEDICINAL CHEMISTRY 11(24) 5311-5316 2003年12月
One-electron reduction characteristics of N(3)-substituted 5-fluorodeoxyuridines synthesized as radiation-activated prodrugs

K Tanabe, Y Mimasu, A Eto, Y Tachi, S Sakakibara, M Mori, H Hatta, S Nishimoto

BIOORGANIC & MEDICINAL CHEMISTRY 11(21) 4551-4556 2003年10月
Formation of Membrane-active form of Amyloid ｲ-Protein in Raft-like Model Membranes.

Biochemical and Biophysisical Research Communication 303(2) 514-518 2003年4月
Photo-induced DNA Cleavage Reaction Characteristics of Propargylic Sulfones Possessing Anthraquinone Chromophore.

Nucleic Acids Research, Supplement 3, 81-82 2003年
Interaction of Amyloid ｲ-Protein with Various Gangliosides in Raft-Like Membrane: Importance of GM1 Ganglioside-Bound Form as an Endogeneous Seed for Altzheimer Amyloid.

Biochemistry 41(23) 7385-7390 2002年6月
Comparison of 5-Fluorouracil and 5-Fluoro-2'-deoxyuridine as an Effector in Radiation-Activated Prodrugs.

Journal of Chemotherapy 14, 390-396 2002年
Discrimination between Cytosine and 5-Methylcytosine in DNA by Peptide Nucleic Acids.

Photomedicine and Photobiology 24, 57-58 2002年
Control of Photo-induced Drug Release by the Use of Conformational Change of DNA.

Nucleic Acids Research, Supplement 2, 167-167 2002年
OH radical reaction of 5-substituted uracils: Pulse radiolysis and product studies of a common redox-ambivalent radical produced by elimination of the 5-substituents

M Mori, S Teshima, H Yoshimoto, S Fujita, R Taniguchi, H Hatta, S Nishimoto

JOURNAL OF PHYSICAL CHEMISTRY B 105(10) 2070-2078 2001年3月
In vivo evaluation of a novel antitumor prodrug, 1-(2 '-oxopropyl)-5-fluorouracil (OFU001), which releases 5-fluorouracil upon hypoxic irradiation

Y Shibamoto, L Zhou, H Hatta, M Mori, S Nishimoto

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 49(2) 407-413 2001年2月
N(1)-C(5)-Linked Dimer Hydrates of 5-Substituted Uracils Produced by Electrolytic Oxidation in Aqueous Solution.

Journal of Organic Chemistry 66,2232-2239 2001年
Photocatalytic Stereoselective N-Cyclization of 2,6-Diaminopimelic Acid into Piperidine-2,6-dicarboxylic Acid by on Aqueous Suspension of Activated Cadmicun((]G0002[))Sulfide Particles.

Journal of Chemical Society. , Perkin Transaction 2 201-209 2001年
Redox Reactions of Nitrite Ions on the Surface of Colloidal Magnetite(Fe₃O₄)-Particles Coated with Chondroitin Sulfate.

Colloidal Polymer Science 279,46-52 2001年
Modification of Radiation Crosslinked Polypropylene.

Radiation Physics and Chemistry 60, 489-493 2001年

もっとみる

書籍等出版物

1

Radiation Dergradation of Stabilization of Polypropylene(共著)

Handbook of Polymer Degradation 1992年

所属学協会

10

Works(作品等)

6

ポリオレフィンの放射線架橋

1999年 - 2001年
Radiation Crosslinking of Polyolefins

1999年 - 2001年
高性能放射線増感剤の開発研究

1987年 - 1999年
Development of Highly Efficient Radiosensitizers

1987年 - 1999年
DNA切断反応性を有するプロパルギルスルホン化合物の合成と構造-活性相関

1996年 - 1997年
Synthesis and Quantitative Structure-Activity Relationship of Propargylic Sulfones

1996年 - 1997年

共同研究・競争的資金等の研究課題

10

産業財産権

11