1992年4月
HEAT-SHOCK RESPONSIVE ELEMENTS IN THE INDUCTION OF THE MULTIDRUG RESISTANCE GENE (MDR1)
FEBS LETTERS
- ,
- ,
- ,
- 巻
- 301
- 号
- 1
- 開始ページ
- 37
- 終了ページ
- 40
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/0014-5793(92)80205-U
- 出版者・発行元
- ELSEVIER SCIENCE BV
The MDR1 gene, considered to be involved in multidrug resistance of cancer cells, is expressed in liver, kidney, small intestine and the blood-brain barrier. We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold. Deletion analysis of the MDR1 promoter indicated that the transcriptional activation after exposure to arsenite depends on a 60-bp region containing two heat-shock responsive elements.
- リンク情報
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- DOI
- https://doi.org/10.1016/0014-5793(92)80205-U
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902047722632670
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/1360409
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1992HQ68100009&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/0014-5793(92)80205-U
- ISSN : 0014-5793
- J-Global ID : 200902047722632670
- PubMed ID : 1360409
- Web of Science ID : WOS:A1992HQ68100009