論文

査読有り
1992年4月

HEAT-SHOCK RESPONSIVE ELEMENTS IN THE INDUCTION OF THE MULTIDRUG RESISTANCE GENE (MDR1)

FEBS LETTERS
  • N KIOKA
  • ,
  • Y YAMANO
  • ,
  • T KOMANO
  • ,
  • K UEDA

301
1
開始ページ
37
終了ページ
40
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/0014-5793(92)80205-U
出版者・発行元
ELSEVIER SCIENCE BV

The MDR1 gene, considered to be involved in multidrug resistance of cancer cells, is expressed in liver, kidney, small intestine and the blood-brain barrier. We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold. Deletion analysis of the MDR1 promoter indicated that the transcriptional activation after exposure to arsenite depends on a 60-bp region containing two heat-shock responsive elements.

リンク情報
DOI
https://doi.org/10.1016/0014-5793(92)80205-U
J-GLOBAL
https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902047722632670
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/1360409
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1992HQ68100009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/0014-5793(92)80205-U
  • ISSN : 0014-5793
  • J-Global ID : 200902047722632670
  • PubMed ID : 1360409
  • Web of Science ID : WOS:A1992HQ68100009

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