1999年10月
Structure-activity relationships of RGD mimetics as fibrinogen-receptor antagonists
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- 巻
- 63
- 号
- 10
- 開始ページ
- 1684
- 終了ページ
- 1690
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1271/bbb.63.1684
- 出版者・発行元
- TAYLOR & FRANCIS LTD
The activities of a series of RGD mimetics, which contained a variety of cationic structures, for the inhibition of platelet aggregation and fibrinogen-receptor binding were measured. The stability of the coulombic ion-pairing complex of the model compounds with the acetate anion as a model for the receptor was calculated in terms of the ionic interaction energy. The results suggest that stability is one of the significant factors which govern the inhibitory potency of fibrinogen-receptor binding. The distance between cationic and anionic groups might also affect the potency. A compound which contained an amidinophenyl structure as the cationic moiety showed exceptionally high inhibitory activity, suggesting that some other factors, in addition to coulombic interaction and the distance, affect the potency.
- リンク情報
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- DOI
- https://doi.org/10.1271/bbb.63.1684
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902114674477608
- CiNii Articles
- http://ci.nii.ac.jp/naid/110002691986
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10586496
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000083489800003&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1271/bbb.63.1684
- ISSN : 0916-8451
- eISSN : 1347-6947
- J-Global ID : 200902114674477608
- CiNii Articles ID : 110002691986
- PubMed ID : 10586496
- Web of Science ID : WOS:000083489800003