論文

査読有り
2007年

Structure-activity relationship and mode of action study of insect growth regulators

JOURNAL OF PESTICIDE SCIENCE
  • Yoshiaki Nakagawa

32
2
開始ページ
135
終了ページ
136
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1584/jpestics.J07-01
出版者・発行元
PESTICIDE SCI SOC JAPAN

A number of NN'-dibenzoyl-N-t-butylhydrazine analogs containing various substituted benzoyl moieties were synthesized and their biological activity was measured using various biological systems. Larvicidal activity against Chilo suppressalis, Spodoptera exigua, and Leptinotarsa decemlineata was measured. In addition, the molting hormone activity was estimated by the ability to stimulate N-acetylglucosamine incorporation into cultured integument fragments from C. suppressalis larvae. Binding affinity to the receptor was assayed using proteins prepared by in vitro translation of the responsible cDNA cloned from a cell-free preparation of larval tissue of C. suppressalis or L. decemlineata. Binding to intact Sf-9 cells, which can be regarded as an index of the receptor binding, was also measured. Variations in the biological activity indices were either analyzed using physicochemical, molecular and substituent parameters or correlated between two difrerent activity types. Comparisons among correlations clearly indicate the physicochemical and biological meaning of parameters significant in the correlation equations to increase our understanding of the molecular mechanism of molting hormones. (C) Pesticide Science Society of Japan.

リンク情報
DOI
https://doi.org/10.1584/jpestics.J07-01
CiNii Articles
http://ci.nii.ac.jp/naid/110006273859
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000246874600012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1584/jpestics.J07-01
  • ISSN : 1348-589X
  • CiNii Articles ID : 110006273859
  • Web of Science ID : WOS:000246874600012

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