J-GLOBAL         Last updated: Jul 30, 2019 at 11:20
Ryukoku University
Faculty of Agriculture,Department of Food Sciences and Human Nutrition
Job title
Doctor of Agriculture

Research Interests


Research Areas


Academic & Professional Experience

Mar 2015
Kyoto University Graduate School of Agriculture, Division of Food Science and Biotechnology


Graduate School, Division of Agriculture, Kyoto University
Faculty of Agriculture, Kyoto University

Published Papers

Evaluating the palatability of fermented foods.
Fushiki T, Nakano K.
Biosci Biotechnol Biochem.   83(8) 1417-1421   Aug 2019   [Refereed]
Hunger promotes the detection of high-fat food.
Appetite   18(142) 104377   Jul 2019   [Refereed]
Chronic high corticosterone with voluntary corn oil ingestion induces significant body weight gain in mice.
Matsumura S, Odanaka M, Ishikawa F, Sasaki T, Manio MCC, Fushiki T, Inoue K.
Physiol Behav   15(204) 112-120   May 2019   [Refereed]
Amygdala activation during unconscious visual processing of food.
Sato W, Kochiyama T, Minemoto K, Sawada R, Fushiki T.
Sci Rep.   1320(9)    May 2019   [Refereed]
Voluntary Corn Oil Ingestion Increases Energy Expenditure and Interscapular UCP1 Expression Through the Sympathetic Nerve in C57BL/6 Mice.
Matsumura S, Ishikawa F, Sasaki T, Odanaka M, Manio MCC, Fushiki T, Inoue K.
Mol Nutr Food Res.   62(22) e1800241   Nov 2018   [Refereed]
Alterations in energy substrate metabolism in mice with different degrees of sepsis.
Irahara T, Sato N, Otake K, Matsumura S, Inoue K, Ishihara K, Fushiki T, Yokota H.
J Surg Res.   227 44-51   Jul 2018   [Refereed]
Allyl isothiocyanate increases carbohydrate oxidation through enhancing insulin secretion by TRPV1.
Mori N, Kurata M, Yamazaki H, Matsumura S, Hashimoto T, Kanazawa K, Nadamoto T, Inoue K,
Biosci Biotechnol Biochem.   82(4) 698-708   Apr 2018   [Refereed]
Homeostatic modulation on unconscious hedonic responses to food.
Sato W, Sawada R, Kubota Y, Toichi M, Fushiki T.
BMC Res Notes.   10(1) 511   Oct 2017   [Refereed]
Evaluation of the comprehensive palatability of Japanese sake paired with dishes by multiple regression analysis based on subdomains.
Nakamura R, Nakano K, Tamura H, Mizunuma M, Fushiki T, Hirata D.
Biosci Biotechnol Biochem.   81(8) 1598-1606   Aug 2017   [Refereed]
Assessment of direct interaction between CD36 and and oxidized glycerophospholipid species.
Tsuzuki S, Yamasaki M, Kozai Y, Sugawara T, Manabe Y, Inoue K, Fushiki T.
J Biochem.   1(162) 163-172   Jul 2017   [Refereed]
Fat Content Modulates Rapid Detection of Food: A Visual Search Study Using Fast Food and Japanese Diet.
Sawada R, Sato W, Toichi M, Fushiki T.FUSHIKI Tohru
Front Psychol.   22(8) 1033   Jun 2017   [Refereed]
Dammarane-type triterpene extracts of Panax notoginseng root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle.
Kitamura K, Takamura Y, Iwamoto T, Nomura M, Iwasaki H, Ohdera M, Murakoshi M, Sugiyama K, Matsuyama K, Manabe Y, Fujii NL, Fushiki T.
Biosci Biotechnol Biochem.   81(2) 335-342   Feb 2017   [Refereed]
Identification of the odor-active volatile compound (Z,Z)-4,7-tridecadienal as a potential ligand for the transmembrane receptor CD36.
Tsuzuki S, Amitsuka T, Okahashi T, Kozai Y, Yamasaki M, Inoue K, Fushiki T.
Biomedical Res.   37(6) 335-342   Feb 2017   [Refereed]
Combined pharmacological activation of AMPK and PPARδ potentiates the effects of exercise in trained mice.
Manio MC, Inoue K, Fujitani M, Matsumura S, Fushiki T.
Physiol Rep.   4(5) e0160956   Aug 2016   [Refereed]
Unconscious Affective Responses to Food.
Sato W, Sawada R, Kubota Y, Toichi M, Fushiki T.
PLoS One.   11(8) e12625   Aug 2016   [Refereed]
A single aldehyde group can serve as a structural element for recognition by transmembrane protein CD36.
Tsuzuki S, Amitsuka T, Okahashi T, Kozai Y, Matsumura S, Inoue K, Fushiki T.
Biosci Biotechnol Biochem.   80(7) 1375-1378   Jul 2016   [Refereed]
Low-intensity exercise in the acute phase of lipopolysaccharide-induced sepsis improves lipid metabolism and survival in mice by stimulating PGC-1α expression.
Irahara T, Sato N, Inoue K, Otake K, Ohtsuru S, Koike K, Fushiki T, Yokota H.
J Trauma Acute Care Surg.   80(6) 933-940   Jun 2016   [Refereed]
Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice.
Kobayashi K, Tanaka T, Okada S, Morimoto Y, Matsumura S, Manio MC, Inoue K, Kimura K, Yagi T, Saito Y, Fushiki T, Inoue H, Matsumoto M, Nabeshima Y.
FASEB J.   30(2) 849-862   Feb 2016   [Refereed]
Expression of CD36 by Olfactory Receptor Cells and Its Abundance on the Epithelial Surface in Mice.
Lee S, Eguchi A, Tsuzuki S, Matsumura S, Inoue K, Iwanaga T, Masuda D, Yamashita S, Fushiki T.
PLoS One.   10(7) e0133412   Jul 2015   [Refereed]
Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity.
Ohta H, Konishi M, Kobayashi Y, Kashio A, Mochiyama T, Matsumura S, Inoue K, Fushiki T, Nakao K, Kimura I, Itoh N.
Sci Rep.   5 10049   May 2015   [Refereed]
The opioid system contributes to the acquisition of reinforcement for dietary fat but is not required for its maintenance.
Sakamoto K, Matsumura S, Okafuji Y, Eguchi A, Yoneda T, Mizushige T, Tsuzuki S, Inoue K, Fushiki T.
Physiol Behav.   138 227-235   Jan 2015   [Refereed]
The opioid system majorly contributes to preference for fat emulsions but not sucrose solutions in mice.
Sakamoto K, Matsumura S, Okafuji Y, Eguchi A, Yoneda T, Mizushige T, Tsuzuki S, Inoue K, Fushiki T.
Physiol Behav.   79(4) 658-663   2015   [Refereed]
Mechanisms Involved in Guiding the Preference for Fat Emulsion Differ Depending on the Concentration.
Sakamoto K, Matsumura S, Okafuji Y, Eguchi A, Lee S, Adachi S, Fujitani M, Tsuzuki S, Inoue K, Fushiki T.
J Nutr Sci Vitaminol   61(3) 247-254   2015   [Refereed]
A role of CD36 in the perception of an oxidised phospholipid species in mice.
Lee S, Eguchi A, Sakamoto K, Matsumura S, Tsuzuki S, Inoue K, Masuda D, Yamashita S, Fushiki T.FUSHIKI Tohru
Biomed Res.   36(5) 303-311   2015   [Refereed]
A recombinant matriptase causes an increase in caspase-3 activity in a small-intestinal epithelial IEC-6 line cultured on fibronectin-coated plates.
Mochida S, Tsuzuki S, Inouye K, Fushiki T.
Cytotechnology.   66(3) 357-363   May 2014   [Refereed]
Behavioral palatability of dietary fatty acids correlates with the intracellular calcium ion levels induced by the fatty acids in GPR120-expressing cells.
Adachi S, Eguchi A, Sakamoto K, Asano H, Manabe Y, Matsumura S, Tsuzuki S, Inoue K, Fushiki T. Biomed Res. 2014;35(6):357-67. doi: 10.2220/biomedres.35.357.
Biomed Res.   35(6) 357-3678   2014   [Refereed]
A study of an aroma extraction method and evaluation of the aroma extract contribution to the palatability and reinforcement effect of dried bonito using mice.
Amitsuka T, Okamura M, Shiibashi H, Yamamoto N, Saito T, Nammoku T, Tsuzuki S, Inoue K, Fushiki T.
J Nutr Sci Vitaminol   60(5) 328-333   2014   [Refereed]
Critical roles of nardilysin in the maintenance of body temperature homoeostasis.
Hiraoka Y, Matsuoka T, Ohno M, Nakamura K, Saijo S, Matsumura S, Nishi K, Sakamoto J, Chen PM, Inoue K, Fushiki T, Kita T, Kimura T, Nishi E.
Nature Commun.   5 3224   2014   [Refereed]
Further validation of unsaturated long-chain fatty acids as inhibitors for oxidized low-density lipoprotein binding to CD36 via assays with synthetic CD36 peptide-cross-linked plates.
Kozai Y, Tsuzuki S, Takai M, Eguchi A, Matsumura S, Inoue K, Fushiki T.
Biosci Biotechnol Biochem.   78(5) 839-842   2014   [Refereed]
Unsaturated long-chain fatty acids inhibit the binding of oxidized low-density lipoproteins to a model CD36.
Takai M, Kozai Y, Tsuzuki S, Matsuno Y, Fujioka M, Kamei K, Inagaki H, Eguchi A, Matsumura S, Inoue K, Fushiki T.
Biosci Biotechnol Biochem.   78(2) 238-244   2014   [Refereed]
CD36, but not GPR120, is required for efficient fatty acid utilization during endurance exercise.
Fujitani M, Matsumura S, Masuda D, Yamashita S, Fushiki T, Inoue K
Biosci Biotechnol Biochem.   78(11) 1871-1878   2014   [Refereed]
Analyzing comprehensive palatability of cheese products by multivariate regression to its subdomains.
Nakano K, Kyutoku Y, Sawa M, Matsumura S, Dan I, Fushiki T.
Food Sci Nutr   1(15) 369-376   Sep 2013   [Refereed]
K. Inouye; M. Tomoishi; M. Yasumoto; Y. Miyake; K. Kojima; S. Tsuzuki; T. Fushiki
Journal of Biochemistry   153(1) 51-61   Jan 2013   [Refereed]
S.-I. Adachi; Y. Endo; T. Mizushige; S. Tsuzuki; S. Matsumura; K. Inoue; T. Fushiki
Bioscience, Biotechnology and Biochemistry   77(11) 2175-2180   2013   [Refereed]
K. Nakano; H. Kubo; S. Matsumura; T. Saito; T. Fushiki
Bioscience, Biotechnology and Biochemistry   77(6) 1166-1170   2013   [Refereed]
M. Takai; S. Tsuzuki; Y. Matsuno; Y. Kozai; A. Eguchi; S. Matsumura; K. Inoue; T. Fushiki
Bioscience, Biotechnology and Biochemistry   77(5) 1134-1137   2013   [Refereed]
N. Mori; M. Kurata; H. Yamazaki; H. Hosokawa; T. Nadamoto; K. Inoue; T. Fushiki
Journal of Nutritional Science and Vitaminology   59(1) 56-63   2013   [Refereed]
S. Tsuzuki; M. Takai; Y. Matsuno; Y. Kozai; M. Fujioka; K. Kamei; H. Inagaki; A. Eguchi; S. Matsumura; K. Inoue; T. Fushiki
Bioscience, Biotechnology and Biochemistry   77(1) 132-137   2013   [Refereed]
H. Yamada; Y. Iwaki; R. Kitaoka; M. Fujitani; T. Shibakusa; T. Fujikawa; S. Matsumura; T. Fushiki; K. Inoue
Journal of Nutritional Science and Vitaminology   58(2) 88-95   2012   [Refereed]
K. Kuramoto; T. Okamura; T. Yamaguchi; T.Y. Nakamura; S. Wakabayashi; H. Morinaga; M. Nomura; T. Yanase; K. Otsu; N. Usuda; S. Matsumura; K. Inoue; T. Fushiki; Y. Kojima; T. Hashimoto; F. Sakai; F. Hirose; T. Osumi
Journal of Biological Chemistry   287(28) 23852-23863   2012   [Refereed]
K. Shintaku; K. Uchida; Y. Suzuki; Y. Zhou; T. Fushiki; T. Watanabe; S. Yazawa; M. Tominaga
British Journal of Pharmacology   165(5) 1476-1486   2012   [Refereed]
S. Matsumura; A. Eguchi; Y. Okafuji; S. Tatsu; T. Mizushige; S. Tsuzuki; K. Inoue; T. Fushiki
FEBS Letters   586(8) 1231-1235   2012   [Refereed]
Relationships between lavender aroma component and aromachology effect
K. Tomi; T. Fushiki; H. Murakami; Y. Matsumura; T. Hayashi; S. Yazawa
Acta Horticulturae   925 299-306   2011   [Refereed]
H. Kawasaki; A. Yamada; R. Fuse; T. Fushiki
Bioscience, Biotechnology and Biochemistry   75(12) 2288-2292   2011   [Refereed]
S. Haramizu; F. Kawabata; K. Ohnuki; N. Inoue; T. Watanabe; S. Yazawa; T. Fushiki
Biomedical Research   32(4) 279-284   2011   [Refereed]
T. Miyaki; T. Fujikawa; R. Kitaoka; N. Hirano; S. Matsumura; T. Fushiki; K. Inoue
Neuroscience   190 239-250   2011   [Refereed]
N. Mori; F. Kawabata; S. Matsumura; H. Hosokawa; S. Kobayashi; K. Inoue; T. Fushiki
American Journal of Physiology - Regulatory Integrative and Comparative Physiology   300(6) 1494-1505   2011   [Refereed]
S. Mochida; S. Tsuzuki; K. Inouye; T. Fushiki
Journal of Biochemistry   148(6) 721-732   Dec 2010   [Refereed]
T. Fujikawa; R. Fujita; Y. Iwaki; S. Matsumura; T. Fushiki; K. Inoue
Physiology and Behavior   101(3) 370-375   Oct 2010   [Refereed]
Y. Yoshikawa; H. Hirayasu; S. Tsuzuki; T. Fushiki
Cytotechnology   62(4) 325-332   Aug 2010   [Refereed]


Influence of neural blockages and proglumide on rat pancreatic enzyme secretion in response to intraluminal fatty acid.
S. Fukuoka; T. Fushiki; M. Kondoh; K. Iwai
Proceedings of the Society for Experimental Biology and Medicine   186(1) 27-35   1987   [Refereed]
T. Hibuse; N. Maeda; T. Funahashi; K. Yamamoto; A. Nagasawa; W. Mizunoya; K. Kishida; K. Inoue; H. Kuriyama; T. Nakamura; T. Fushiki; S. Kihara; I. Shimomura
Proceedings of the National Academy of Sciences of the United States of America   102(31) 10993-10998   Aug 2005   [Refereed]
The palatability of long-chain fatty acids to mice
Tohru Fushiki
The 6th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception      2008   [Refereed]
Tohru Fushiki
18th Congress of Europian Chemoreception Research Organization      2008   [Refereed]
Long-chain fatty acids induce intracellular Ca2+ via G-protein coupled Receptor 120 and positive licking behavior in mice
Tohru Fushiki
XV International symposium on olfaction and taste      2008   [Refereed]

Books etc

Introduction to Japanese Cuisine
FUSHIKI Tohru (Part:Contributor)
Aug 2015   
FUSHIKI Tohru (Part:Joint Editor)
Aug 2015   
Fat Detection
FUSHIKI Tohru (Part:Contributor)
Dec 2010   
Biology of the Pancreas in Growing Animals (S. G. Pierzynowski & R. Zabielski eds. )
伏木 亨
Elsevior Science,/,249-259   1999   
Obesity : Dietary factors and control(eds. D. R. Romsos etal. )
伏木 亨
KARGER,   1991   

Conference Activities & Talks

Importance of traditional umami tastefor next generation's foods
Korean Society of Food Science and Nutrition (KFN) International Symposium   2009   
Ligand specificities to putative fat receptor candidates CD36 and GPR120 and licking behavior corresponding to the ligands in mice
AChemS 2009 Annual Meeting XXXI   2009   

Research Grants & Projects

Effects of food and nutrients on exercise capacity
Recognition of foods by gastrointestinal tract.
Foods and autonomic nervous system