New prevention strategy for Alzheimer's disease based on the toxic conformation of amyloid β, Japan Society for Bioscience, Biotechnology, and Agrochemistry Award in 2019, Japan Society for Bioscience, Biotechnology, and Agrochemistry
2009
Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry in 2008 (Japan Society for Bioscience, Biotechnology, and Agrochemistry)
1994
The Japan Bioscience, Biotechnology and Agrochemistry Society Award for the Encouragement of Young Scientists
Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer’s disease model
T. Imamura, Y. T. Yanagihara, Y. Ohyagi*, N. Nakamura, K. M. Iinuma, R. Yamasaki, H. Asai, M. Maeda, K. Murakami, K. Irie, J.-i. Kira*
Neurobiol. Dis., in press 2020 [Refereed]
New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β
Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties
K. Murakami* and K. Irie*
Molecules 24 2125 2019 [Refereed][Invited]
分子模型
K. Irie
化学と生物 57(5) 263-263 2019 [Invited]
Curcumin may induce lipolysis via proteo-stress in Huh7 human hepatoma cells
C. Valentine, K. Ohnishi, K. Irie and A. Murakami*
J. Clin. Biochem. Nutr. 65(2) 91-98 2019 [Refereed]
An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease
N. Izuo, K. Murakami, Y. Fujihara, M. Maeda, T. Saito, T. C. Saido, K. Irie and T. Shimizu*
Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid beta40 with a toxic conformation
Y. Irie, M. Hanaki, K. Murakami, T. Imamoto, T. Furuta, T. Kawabata, T. Kawase, K. Hirose, Y. Monobe, K.-i. Akagi, R. C. Yanagita and K. Irie*
Chem. Commun. 55 182-185 2019 [Refereed]
アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発
泉尾直孝*，清水孝彦，村上一馬，入江一浩
医薬品医療機器レギュラトリーサイエンス 49(5) 312-318 2018
Amylod beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques
Y. Kageyama, A. Saito, O. Pletnikova, G. L. Rudow, Y. Irie, Y. An, K. Murakami, K. Irie, S. M. Resnick, D. R. Fowler, L. J. Martin and J. C. Troncoso*
Sci. Rep. 8 16895 2018 [Refereed]
Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin
Y. Ashida, R. C. Yanagita*, Y. Kawanami, M. Okamura, S. Dan and K. Irie
Heterocycles 99(2) 942-957 2019 [Refereed]
Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers
K. Murakami, T. Yoshioka, S. Horii, M. Hanaki, S. Midorikawa, S. Taniwaki, H. Gunji, K.-i. Akagi, T. Kawase, K. Hirose and K. Irie*
Chem. Commun. 54 6272-6275 2018 [Refereed]
Change of amyloid-beta 1-42 toxic conformer ratio after cerebrospinal fluid diversion predicts long-term cognitive outcome in patients with idiopathic normal pressure hydrocephalus
C. Akiba*, M. Nakajima, M. Miyajima, I. Ogino, Y. Motoi, K. Kawamura, S. Adachi, A. Kondo, H. Sugano, T. Tokuda, K. Irie and H. Arai
J. Alzheimers Dis. 63(3) 989-1002 2018 [Refereed]
Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin
K. Hayakawa, Y. Hanaki, H. Tokuda, R. C. Yanagita, Y. Nakagawa, M. Okamura, S. Dan and K. Irie*
Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie and H. Shigemori*
Heterocycles 94(7) 1280-1287 2017 [Refereed]
Synthesized Aβ42 caused intracellular oxidative damage, leading to cell death, via lysosome rupture
Y. Oku, K. Murakami, K. Irie, J. Hoseki and Y. Sakai*
Cell Struct. Funct. 42(1) 71-79 2017 [Refereed]
Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity
Y. Irie, K. Murakami, M. Hanaki, Y. Hanaki, T. Suzuki, Y. Monobe, T. Takai, K. Akagi, T. Kawase, K. Hirose and K. Irie*
ACS Chem. Neurosci. 8(4) 807-816 2017 [Refereed]
Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities
Y. Hanaki, M. Kikumori, H. Tokuda, M. Okamura, S. Dan, N. Adachi, N. Saito, R. C. Yanagita and K. Irie*
K. Murakami, M. Tokuda, T. Suzuki, Y. Irie, M. Hanaki, N. Izuo, Y. Monobe, K.-i. Akagi, R. Ishii, H. Tatebe, T. Tokuda, M. Maeda, T. Kume, T. Shimizu and K. Irie*
H. Takahashi, N. Adachi, T. Shirafuji, S. Danno, T. Ueyama, M. Vendruscolo, A. N. Shuvaev, T. Sugimoto, T. Seki, D. Hamada, K. Irie, H. Hirai, N. Sakai and N. Saito*
A. Hashimoto, K. Ohkura, M. Takahashi, K. Kizu, H. Narita, S. Enomoto, Y. Miyamae, S. Masuda, M. Nagao, K. Irie, H. Ohigashi, G. K. Andrews, and T. Kambe*
A. Ohtera, Y. Miyamae, N. Nakai, A. Kawachi, K. Kawada, J. Han, H. Isoda, M. Neffati, T. Akita, K. Maejima, S. Masuda, T. Kambe, N. Mori, K. Irie and M. Nagao*
Y. Hanaki, M. Kikumori, S. Ueno, H. Tokuda, N. Suzuki and K. Irie*
Tetrahedron 69(36) 7636-7645 2013 [Refereed]
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer’s disease
N. Soejima, Y. Ohyagi*, N. Nakamura, E. Himeno, K. M. Iimura, N. Sakae, R. Yamasaki, T. Tabira, K. Murakami, K. Irie, N. Kinoshita, F. M. Laferla, Y. Kiyohara, T. Iwaki and J.-i. Kira
K. Ohnishi, S. Ohkura, E. Nakahata, A. Ishisaka, Y. Kawai, J. Terao, T. Mori, T. Ishii, T. Nakayama, N. Kioka, S. Matsumoto, Y. Ikeda, M. Akiyama, K. Irie and A. Murakami*
L. Kulic*, J. McAfoose, T. Welt, C. Tackenberg, C. Späni, F. Wirth, V. Finder, U. Konietzko, M. Giese, A. Eckert, N. Kinoshita, T. Shimizu, K. Murakami, K. Irie, S. Rasool, C. Glabe, C. Hock and R. M. Nitsch
第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区） Dec 2016 [Invited]
ウンカリン酸によるアミロイドβ凝集核形成の選択的阻害
吉岡卓也 他
第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区） Dec 2016
アミロイドβ40の2量体モデルの合成と神経細胞毒性
入江由美 他
第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区） Dec 2016
アプリシアトキシンおよびジアシルグリセロールの受容体認識部位の構造活性相関研究
芦田能基 他
2016年日本化学会中国四国支部大会 香川大会（香川大学幸町北キャンパス、高松市） Nov 2016
Structural optimization and mechanistic analysis of the anto-proliferative activity of aplog-1, a simplified analog of debromoaplysiatoxin
Yusuke Hanaki et al.
58th Symposium on the chemistry of natural products Sep 2016 [Refereed]
Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer’s disease
N. Izuo et al.
2016 Spring International Conference of the Korean Society for Gerontology (Hotel Laonzena, Convention Hall) (Daegu, Korea) Jun 2016
Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する
泉尾直孝 他
日本基礎老化学会大会（伊勢原市民文化会館、伊勢原市） May 2016
Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition
泉尾直孝 他
第89回日本薬理学会年会（パシフィコ横浜、横浜市） Mar 2016
アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用
村上一馬 他
2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市） Mar 2016
新規抗がん剤シード・10-Me-aplog-1のがん細胞増殖抑制機構
花木祐輔 他
2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市） Mar 2016
チョウトウコウに含まれるウンカリン酸Ｃおよびその誘導体のアミロイドβ凝集阻害活性
吉岡卓也 他
2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市） Mar 2016
分子モデリングによるAplysiatoxinとプロテインキナーゼC C1ドメインとの結合様式の予測
芦田能基 他
2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市） Mar 2016
Thapsigargin のC1ドメインに対する結合能と結合選択性の評価
高橋知世 他
2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市） Mar 2016
新規抗がん剤シード・aplog類のがん細胞増殖抑制機構の解析
花木祐輔 他
新学術領域研究「天然物ケミカルバイオロジー〜分子標的と活性制御〜」地区ミニシンポジウム（京都大学、京都市） Feb 2016
Large-scale synthesis, anti-cancer activity in vivo, and mechanism of anti-proliferative activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as an anti-cancer lead
Y. Hanaki et al.
The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takea Pharmaceutical Company, Ltd.) (Suita, Japan) Jan 2016
Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease
K. Murakami et al.
The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takeda Pharmaceutical Company, Ltd.) (Suita, Japan) Jan 2016
Extraction of anti-proliferative activity from pleiotropic debromoaplysiatoxin, a potent tumor promoter and a highly inflammatory principle isolated from sea hare
K. Irie et al.
2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA) Dec 2015 [Invited]
New lyngbyatoxin derivatives from the Hawaiian cyanobacterium Moorea producens
W. Jiang et al.
2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA) Dec 2015
Structure–activity studies on the PKC-recognition domain of aplysiatoxin, a potent tumor-promoter isolated from a sea hare
Y. Ashida et al.
2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA) Dec 2015
Isolation and ability to bind to protein kinase C of (20S)-bryostatin 19 from Japanese bryozoan: elucidation of the role of the side-chain at position 20
R. C. Yanagita et al.
2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA) Dec 2015
Synthesis and biological activities of the amide derivative of aplog-1
Y. Hanaki et al.
2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA) Dec 2015
Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease.
K. Murakami et al.
2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA) Dec 2015 [Invited]
Structural insight into the inhibitory mechanism of amyloid β42 aggregation by non-catechol-type flavonoids
M. Hanaki et al.
2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA) Dec 2015
アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用
村上一馬，入江一浩
第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所、熊取町） Nov 2015
In vitro display evolution of cyclized peptidomimetics to a chemically synthesized amyloid beta protein dimer
2019年度日本農芸化学会大会（東京農大、東京） 25 Mar 2019 公益社団法人 日本農芸化学会
アミロイドβの毒性を示す立体構造の同定とアルツハイマー病診断への応用[Invited]
IRIE Kazuhiro
第125回 支援センターセミナー（滋賀医科大学） 15 May 2018
Development of monoclonal antibody with specificity for a toxic conformer of amyloid β and its application toward the Alzheimer’s disease diagnosis and therapeutics[Invited]
Kazuhiro Irie
Seminar in The Florey Institute, The University of Melbourne, Australia 20 Feb 2018
Inhibitory mechanism for amyloid beta42 aggregation by flavonoids[Invited]
Kazuhiro Irie
Kyoto-Bordeaux Symposium 2015 22 May 2015 Kyoto University and University of Bordeaux
抗がん剤開発を指向した新規プロテインキナーゼＣリガンドの創製[Invited]
Kazuhiro Irie
24 Jun 2014
Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin[Invited]
Kazuhiro Irie
International Symposium on Natural Products Chemistry and Chemical Biology 26 Nov 2013 JSPS, Asian CORE Program
Structure-activity studies on a simplified analog of debromoaplysiatoxin with anti-proliferative activity[Invited]
Kazuhiro Irie
The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity 31 Oct 2012 Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY
Development of new molecular probes and therapeutic seeds having skeletons of naturally-occurring tumor promoters[Invited]
Kazuhiro Irie
22nd French-Japanese Symposium of Medicinal and Fine Chemistry (Rouen, France) 13 Sep 2011
Synthesis and structure-activity studies of the simplified analogue of aplysiatoxin with antiproliferative activity like bryostatin 1[Invited]
Kazuhiro Irie
27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia) 11 Jul 2011
Development of anticancer compounds using the skeleton of tumor promoter aplysiatoxin[Invited]
Kazuhiro Irie
The 25th Naito Conference, Chemical Biology [II] -An Emerging Field Inspired by Natural Product Chemistry- (Sapporo, Japan) 2009
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