Hisashi Miyagawa

Profile Information

Affiliation: Professor,Professor, Graduate School of Agriculture, Division of Applied Life Sciences, Graduate School of Agriculture Division of Applied Life Sciences, Kyoto University

Degree: Master of Agriculture(Kyoto University)
Doctor of Agriculture(Kyoto University)

J-GLOBAL ID: 200901069268559432
researchmap Member ID: 1000028352

Research Interests

Research Areas

Life sciences / Bioorganic chemistry /

Education

- 1982

Kyoto University
- 1982

Graduate School, Division of Agriculture, Kyoto University
- 1980

Faculty of Agriculture, Kyoto University
- 1980

Faculty of Agriculture, Kyoto University

Committee Memberships

Papers

165

Molecular Diversity of Linear Peptides Revealed by Transcriptomic Analysis of the Venom Gland of the Spider Lycosa poonaensis

Alhussin Mohamed Abdelhakeem Megaly, Masahiro Miyashita, Mohammed Abdel-Wahab, Yoshiaki Nakagawa, Hisashi Miyagawa

TOXINS, 14(12), Dec, 2022
A luciferase reporter assay for ecdysone agonists using HEK293T cells

Taiyo Yokoi, Taku Nabe, Chiharu Ishizuka, Ken'ichiro Hayashi, Sayoko Ito-Harashima, Takashi Yagi, Yoshiaki Nakagawa, Hisashi Miyagawa

Bioscience, Biotechnology, and Biochemistry, Aug 17, 2022
Characterization of 2 linear peptides without disulfide bridges from the venom of the spider Lycosa poonaensis (Lycosidae)

Alhussin M A Megaly, Yusuke Yoshimoto, Yugo Tsunoda, Masahiro Miyashita, Mohammed Abdel-Wahab, Yoshiaki Nakagawa, Hisashi Miyagawa

Bioscience, Biotechnology, and Biochemistry, 85(6) 1348-1356, May 25, 2021
Quantitative analysis of auxin metabolites in lychee flowers

Ryunhee Kim, Yutaro Osako, Hisayo Yamane, Ryutaro Tao, Hisashi Miyagawa

Bioscience, biotechnology, and biochemistry, 85(3) 467-475, Feb 24, 2021
Quantitative analysis of auxin metabolites in lychee flowers.

Ryunhee Kim, Yutaro Osako, Hisayo Yamane, Ryutaro Tao, Hisashi Miyagawa

Bioscience, biotechnology, and biochemistry, 85(3) 467-475, Feb 24, 2021
Identification of an antiviral component from the venom of the scorpion Liocheles australasiae using transcriptomic and mass spectrometric analyses

Masahiro Miyashita, Naoya Mitani, Atsushi Kitanaka, Mao Yakio, Ming Chen, Sachiko Nishimoto, Hironobu Uchiyama, Masayuki Sue, Hak Hotta, Yoshiaki Nakagawa …

Toxicon, 191 25-37, Feb, 2021
Identification and in silico prediction of metabolites of tebufenozide derivatives by major human cytochrome P450 isoforms.

Hiroaki Edamatsu, Masataka Yagawa, Shinichi Ikushiro, Toshiyuki Sakaki, Yoshiaki Nakagawa, Hisashi Miyagawa, Miki Akamatsu

Bioorganic & medicinal chemistry, 28(9) 115429-115429, May 1, 2020 Peer-reviewed
Identification of antimicrobial components from the venom of the scorpion Liocheles australasiae using an integrated mass spectrometric and transcriptomic approach.

Masahiro Miyashita, Naoya Mitani, Atsushi Kitanaka, Mao Yakio, Ming Chen, Sachiko Nishimoto, Hak Hotta, Yoshiaki Nakagawa, Hisashi Miyagawa

Toxicon : official journal of the International Society on Toxinology, 177 Suppl 1 S45-S46, Apr 20, 2020
A Fluorescent Compound from the Exuviae of the Scorpion, Liocheles australasiae

Yusuke Yoshimoto, Masato Tanaka, Masahiro Miyashita, Mohammed Abdel-Wahab, Alhussin M. A. Megaly, Yoshiaki Nakagawa, Hisashi Miyagawa

Journal of Natural Products, 83(2) 542-546, Feb 28, 2020
Isolation and characterization of the insecticidal, two-domain toxin LaIT3 from the Liocheles australasiae scorpion venom

Hironori Juichi, Masahiro Miyashita, Yoshiaki Nakagawa, Hisashi Miyagawa

Bioscience, Biotechnology, and Biochemistry, 83(12) 2183-2189, Dec 2, 2019
Isolation and Characterization of Insecticidal Toxins from the Venom of the North African Scorpion, Buthacus leptochelys

Yusuke Yoshimoto, Masahiro Miyashita, Mohammed Abdel-Wahab, Moustafa Sarhan, Yoshiaki Nakagawa, Hisashi Miyagawa

Toxins, 11(4) 236-236, Apr 25, 2019
Involvement of Indole-3-Acetic Acid Metabolism in the Early Fruit Development of the Parthenocarpic Tomato Cultivar, MPK-1

Rihito Takisawa, Hideto Kusaka, Yuto Nishino, Masahiro Miyashita, Hisashi Miyagawa, Tetsuya Nakazaki, Akira Kitajima

Journal of Plant Growth Regulation, 38(1) 189-198, Mar, 2019
Chemical synthesis of a two-domain scorpion toxin LaIT2 and its single-domain analogs to elucidate structural factors important for insecticidal and antimicrobial activities.

Juichi H, Ando R, Ishido T, Miyashita M, Nakagawa Y, Miyagawa H

Journal of peptide science : an official publication of the European Peptide Society, 24(12) e3133, Dec, 2018 Peer-reviewed
Complete de novo sequencing of antimicrobial peptides in the venom of the scorpion Isometrus maculatus

Masahiro Miyashita, Atsushi Kitanaka, Mao Yakio, Yuzo Yamazaki, Yoshiaki Nakagawa, Hisashi Miyagawa

TOXICON, 139 1-12, Dec, 2017 Peer-reviewed
Quantitative structure-activity relationship of substituted imidazothiadiazoles for their binding against the ecdysone receptor of Sf-9 cells

Taiyo Yokoi, Yoshiaki Nakagawa, Hisashi Miyagawa

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27(23) 5305-5309, Dec, 2017 Peer-reviewed
Brassinolide-like activity of castasterone analogs with varied side chains against rice lamina inclination

Bunta Watanabe, Shuji Yamamoto, Taiyo Yokoi, Airi Sugiura, Shinri Horoiwa, Takanori Aoki, Hisashi Miyagawa, Yoshiaki Nakagawa

BIOORGANIC & MEDICINAL CHEMISTRY, 25(17) 4566-4578, Sep, 2017 Peer-reviewed
How people know what pesticides are?

MIYAGAWA Hisashi

Japanese Journal of Pesticide Science, 42(1) 153-158, Feb, 2017 Invited
A Facile Method for Preferential Modification of the N-Terminal Amino Group of Peptides Using Triazine-Based Coupling Reagents.

Kitanaka A, Juichi H, Nihashi Y, Miyashita M, Miyagawa H

Mass spectrometry (Tokyo, Japan), 6(1) A0059, 2017 Peer-reviewed
Discovery of a nonsteroidal brassinolide-like compound, NSBR1

Airi Sugiura, Shinri Horoiwa, Takanori Aoki, Seisuke Takimoto, Ayumi Yamagami, Takeshi Nakano, Yoshiaki Nakagawa, Hisashi Miyagawa

JOURNAL OF PESTICIDE SCIENCE, 42(3-4) 105-111, 2017 Peer-reviewed
N-Terminal Derivatization with Structures Having High Proton Affinity for Discrimination between Leu and Ile Residues in Peptides by High-Energy Collision-Induced Dissociation

Kitanaka Atsushi, Miyashita Masahiro, Kubo Ayumi, Satoh Takaya, Toyoda Michisato, Miyagawa Hisashi

Mass Spectrometry, 5(1) A0051-A0051, Dec, 2016 Peer-reviewed

Misc.

141

農薬の創製研究の動向

宮川恒

日本農薬学会誌, 44 101-102, 2019
藤田稔夫先生を偲んで

宮川恒

日本農薬学会誌, 43(1) 99-100, 2018
Toshio Fujita, 1929-2017 Obituary

Yoshiaki Nakagawa, Hisashi Miyagawa

JOURNAL OF PESTICIDE SCIENCE, 42(3-4) 177-178, 2017
ブラシノステロイドの側鎖部分の構造と活性の関係

横井大洋, 山本修資, 杉浦愛理, 渡辺文太, 中川好秋, 宮川恒

日本農芸化学会2016年度大会，札幌, Mar 28, 2016
農薬と食の安全・信頼

宮川恒

日本農薬学会誌, 41 275-275, 2016
ブラシノステロイド類の構造活性相関とインシリコドッキングによる受容体リガンド相互作用の解析

中川好秋, 杉浦愛理, 横井大洋, 渡辺文太, 宮川恒

日本農薬学会第40回大会，東京, Mar 19, 2015
58. Relationship between degradation of PIP-1 and accumulation of secondary metabolites

Kim Yonghyun, Miyashita Masahiro, Miyagawa Hisashi

49 76-76, Oct 1, 2014
Synthesis of N-(2-phenyl-1H-imidazol-1-yl) benzamide analogs and measurement of binding to the ecdysone receptor and molting hormonal activity using a reporter gene assay

Saki Minami, Taiyo Yokoi, Seisuke Takimoto, Yoshiaki Nakagawa, Hisashi Miyagawa

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248, Aug, 2014
Mechanism of tolnifanide resistance: Single amino acid substitutions of geranylgeranyl transferase and farnesyl transferase confer tolnifanide-resistances

Kosuke Izumitsu, Hisashi Miyagawa, Chihiro Tanaka

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248, Aug, 2014
Structure-activity relationships of thiadiazoloimidazole-type ecdysone agonists for binding to sf-9 cells

Taiyo Yokoi, Yoshiaki Nakagawa, Hisashi Miyagawa

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248, Aug, 2014
B305 Synthesis of N-(2-phenyl-lH-imidazol- l -yl)benzamide analogs and evaluation of their binding activity against ecdysone receptors

Yokoi Taiyo, Takimoto Seisuke, Nakagawa Yoshiaki, Miyagawa Hisashi

(38) 123-123, Mar 14, 2013
B315 Accumulation of aromatic amines in barley leaves infected by Bipolaris sorokiniana

Ishihara Atsushi, Yagi Yukari, Miyagawa Hisashi, Nakajima Hiromitsu

(38) 133-133, Mar 14, 2013
C215 Improvement of stability of PIP-1 to enzymatic degradation and its effects on plant defense activation

Kim Yonghyun, Miyashita Masahiro, Miyagawa Hisashi

(38) 107-107, Mar 14, 2013
Total Chemical Synthesis of La1, the Most Abundant Peptide in the Venom of the Scorpion Liocheles australasiae

NAGAO Junya, MIYASHITA Masahiro, NAKAGAWA Yoshiaki, MIYAGAWA Hisashi

2012 149-150, Mar 1, 2013
Isolation and Characterization of Two Novel β-Toxins from the Venom of the Scorpion Isometrus maculatus

MIYASHITA Masahiro, KAWACHI Tomoyuki, ICHIKI Yayoi, NAKAGAWA Yoshiaki, MIYAGAWA Hisashi

2012 155-156, Mar 1, 2013
第5回環太平洋農薬科学会議

宮川恒

日本農薬学会誌, 38 47-94, 2013
96. The metabolism of rice defense substance serotonin by Bipolaris oryzae

Fukami Arisa, Ishihara Atsushi, Miyagawa Hisashi, Nakajima Hiromitsu

47 113-113, Oct 5, 2012
A202 Binding activity of N-subsitutd phenyl-y-lactam analogs against ecdysone receptor proteins and their transactivation activity

Akahane Sho, Nakagawa Yoshiaki, Miyagawa Hisashi

(37) 62-62, Mar 14, 2012
B320 NMR solution structure of an insecticidal toxin LaIT 1 from the venom of scorpion Liocheles australasiae

Miyashita Masahiro, Horita Shoichiro, Miyakawa Takuya, Nakagawa Yoshiaki, Nagata Koji, Tanokura Masaru, Miyagawa Hisashi

(37) 135-135, Mar 14, 2012
C314 Accumulation of serotonin and serotonin derivatives in barlay infected by pathogenic fungi.

Ishihara Atsushi, Hayashi Noriko, Kumeda Rie, Fukami Arisa, Wakasa Kyo, Miyagawa Hisashi, Nakajima Hiromitsu

(37) 151-151, Mar 14, 2012

Books and Other Publications

新版農薬の科学

宮川恒 (Role: Joint editor)

朝倉書店, Feb, 2019
病原菌と植物二次代謝産物

宮川恒

次世代の農薬開発（ソフトサイエンス社）,/ , 2-14, 2003
A new Biorational Approach to development of Herbicides from Fungal Metabolites

宮川恒

Phytochemicals for Pest Control,/,239, 1997
Endogenous Components that Regulate Spore Germination of Phytopatho-genic Fungi

宮川恒

,/,203, 1997
植物病原菌胞子の発芽を制御する内因性活性物質

宮川恒 (Role: Contributor)

植物病害の化学,/,203, 1997
A Chemical Approach for Elucidating the Molecular Interaction of Host-Specific AK-toxin with Japanese pear

宮川恒 (Role: Contributor)

Advances in Microbial Toxin Research and Its Biotechnological Exploitation,1-21

Presentations

新規エリシターペプチドの植物における防御応答誘導機構

小野友慈, 菰田依里子, 宮下正弘, 宮川恒

日本農薬学会大会講演要旨集, Apr 21, 2010
ヤエヤマサソリ毒液由来の殺虫性ペプチドLaIT1の構造活性相関

宮川恒

日本農芸化学会2010年度大会, 2010
Native Chemical Ligation法によるサソリ毒素ペプチドLaIT1の効率的合成

宮川恒

日本農芸化学会関西支部大会第466回講演会, 2010
ヤエヤマサソリ毒液由来殺虫性ペプチドLaIT1の構造と活性

宮川恒

第25回農薬デザイン研究会, 2010
ヒト代謝酵素CYP3A4とCYP2C19の基質認識機構における差異

宮川恒

日本農薬学会第35回大会, 2010
マダラサソリ毒液に含まれる殺虫性ペプチド Im-3 の単離と同定

宮川恒

日本農薬学会第35回大会, 2010
Native Chemical Ligation 法を用いた殺虫性ペプチド LaIT1 の効率的合成

宮川恒

日本農薬学会第35回大会, 2010
イネsl変異体におけるインドール-3-酢酸の蓄積

宮川恒

日本農薬学会第35回大会, 2010
昆虫脱皮ホルモン受容体リガンドの分子設計

宮川恒

日本農薬学会第35回大会, 2010
Characterization of insect toxins isolated from the venom of the scorpion Liocheles australasiae

Hisashi Miyagawa

12th IUPAC International Congress of Pesticide Chemitry, 2010
Virtual Screening for Novel Ligands of Molting Hormonal Receptor

Hisashi Miyagawa

12th IUPAC International Congress of Pesticide Chemitry, 2010
Comparison of the activity of various ecdysone agonists evaluated against intact insect cells and in vitro translated EcR/USP proteins

Hisashi Miyagawa

12th IUPAC International Congress of Pesticide Chemitry, 2010
Effects of tryptophan decarboxylase inhibition on defense responses of rice

Hisashi Miyagawa

12th IUPAC International Congress of Pesticide Chemitry, 2010
Investigation of the defense responses induced by the novel plant immunity-activating peptide, PIP-1

Hisashi Miyagawa

12th IUPAC International Congress of Pesticide Chemitry, 2010
ヤエヤマサソリにおける脱皮ホルモンの探索

宮川恒

日本農芸化学会2009年度大会, 2009
イネの新規IAA代謝物インドール-3-カルボン酸グルコースエステルの同定

宮川恒

日本農芸化学会2009年度大会, 2009
トリプトファンデカルボキシラーゼ阻害剤の開発とイネの抵抗反応に及ぼす効果

宮川恒

日本農芸化学会2009年度大会, 2009
マダラサソリ(Isometrus maculatus)より単離したペプチド毒素Im-1の昆虫毒性ならびに抗菌活性の評価

宮川恒

日本農芸化学会関西支部第462回講演会, 2009
オリゴアルギニンの植物細胞に対する透過性と新規エリシタースクリーニングへの応用

宮川恒

日本農薬学会第34回大会, 2009
イネの新規IAA酸化代謝物の同定

宮川恒

日本農薬学会第34回大会, 2009

Professional Memberships

Research Projects

Elucidation of stress response mechanisms in plants through quantitation of auxin and its metabolites

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

MIYAGAWA HISASHI
Development of a reliable peptidomics technique using a novel chemical derivatization approach

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Miyagawa Hisashi, MIYASHITA Masahiro
Identification of the mode of action of fungicides by whole genome analysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Aug, 2013 - Mar, 2015

IZUMITSU Kosuke, MIYAGAWA Hisashi, TANAKA Chihiro, SUZUKI Kazumi
Exploration of chemical probes for investigation of oxidative metabolism of auxins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

MIYAGAWA Hisashi
Elucidation of adaptation mechanisms of lichens for dry condition used secondary metabolites from isolated mycobiont cultured in liquid medium

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

HAMADA Nobuo, MIYAGAWA Hisashi, MIYAWAKI Hiromi
内分泌攪乱物質による生殖毒性評価システムの構築:構造生物学・細胞生物学的リアルタイム評価法の確立

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2001 - 2003

宮本元, 眞鍋昇, 宮川恒, 杉本実紀, 眞鍋昇, 九郎丸正道, 奥田潔, 木曾康郎, 宮本元
Elucidation of symbiotic mechanisms in lichens used secretions from algal partner

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2001

HAMADA Nobuo, MIYAGAWA Hisashi, MIYAWAKI Hiromi
Recognition mechanism of β-1,3-oligosaccharide elicitor in plants

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1999 - 2000

MIYAGAWA Hisashi
Development of plant disease diagnositic techniques based on chemical analysis of plant-microbe interactions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1998 - 2000

UENO Tamio, AKAMATSU Miki, MIYAGAWA Hisashi
Screening new substances produced by lichen mycobionts cultured under osmotic condition

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1997 - 1998

HAMADA Nobuo, MIYAGAWA Hisashi, MIYAWAKI Hiromi
Design of nonsteroidal durassinosteroids

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1997 - 1998

NAKAGAWA Yoshiaki, MIYAGAWA Hisashi
Induction of plant phenolic amides by oligosaccharides

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1997 - 1998

MIYAGAWA Hisashi
Molecular Genetics of Host-Specific Toxins in Plant Disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for international Scientific Research, Japan Society for the Promotion of Science, 1996 - 1998

KOHMOTO Keisuke, ITOH Yasuo, AKIMITSU Kazuya, TSUGE Takashi, KODAMA Motoichiro, OHTANI Hiroshi
Chemical Factors Regulating Soil Borne Plant Diseases Produced by Microorganisms Surviving in Soil

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1991 - 1992

UENO Tamio, MIYAGAWA Hisashi
Chemical Studies on Mycoalexin Produced by Fungi

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1989 - 1990

UENO Tamio, MIYAGAWA Hisashi, NISHIDA Ritsuo
アントラニル酸に関連する植物二次代謝

ＪＳＴ戦略的創造研究推進制度（研究チーム型）（戦略的基礎研究推進事業：ＣＲＥＳＴ）
地衣菌類の生産する二次代謝物に関する研究
植物と病原菌との相互作用に関する化学的研究
Plant Secondary Metabolism related to Anthranilate

JST Basic Research Programs (Core Research for Evolutional Science and Technology :CREST)
Study on Secondary-metabolites produced by Lichen Mycobiont

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