2005年3月
Formation of ceramide-enriched domains in lipid particles enhances the binding of apolipoprotein E
FEBS LETTERS
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- 巻
- 579
- 号
- 7
- 開始ページ
- 1759
- 終了ページ
- 1764
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.febslet.2005.02.018
- 出版者・発行元
- ELSEVIER SCIENCE BV
We investigated the interaction between apolipoprotein E (apoE) and ceramide (CER)-enriched domains on the particles, by using lipid emulsions containing sphingomyelin (SM) or CER as model particles of lipoproteins. The sphingomyelinase (SMase)-induced aggregation of emulsion particles was prevented by apoE. CER increased the amount of apoE bound to emulsion particles. The confocal images of CER-containing large emulsions with two fluorescent probes showed three-dimensional microdomains enriched in CER. SMase also induced the formation of CER-enriched domains. We propose apoE prefers to bind on CER-enriched domains exposed on particle surface, and thus inhibits the aggregation or fusion of the particles. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
- リンク情報
- ID情報
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- DOI : 10.1016/j.febslet.2005.02.018
- ISSN : 0014-5793
- Web of Science ID : WOS:000227657500031