2014年10月
Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
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- 巻
- 57
- 号
- 12
- 開始ページ
- 680
- 終了ページ
- 686
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/jlcr.3232
- 出版者・発行元
- WILEY-BLACKWELL
Microwave technology has been successfully applied to enhance the effectiveness of radiolabeling reactions. The use of a microwave as a source of heat energy can allow chemical reactions to proceed over much shorter reaction times and in higher yields than they would do under conventional thermal conditions. A microwave reactor developed by Resonance Instrument Inc. (Model 520/521) and CEM (PETWave) has been used exclusively for the synthesis of radiolabeled agents for positron emission tomography by numerous groups throughout the world. In this study, we have developed a novel resonant-type microwave reactor powered by a solid-state device and confirmed that this system can focus microwave power on a small amount of reaction solution. Furthermore, we have demonstrated the rapid and facile radiosynthesis of 16-[F-18]fluoroestradiol, 4-[F-18]fluoro-N-[2-(1-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinylbenzamide, and N-succinimidyl 4-[F-18]fluorobenzoate using our newly developed microwave reactor.
- リンク情報
- ID情報
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- DOI : 10.1002/jlcr.3232
- ISSN : 0362-4803
- eISSN : 1099-1344
- PubMed ID : 25294422
- Web of Science ID : WOS:000345323000004