後藤隆洋 (Takahiro Gotow) - マイポータル

基本情報

学位: 医学博士(大阪大学)
理学修士(岡山大学)

J-GLOBAL ID: 200901060623268277
researchmap会員ID: 1000029523

研究キーワード

研究分野

経歴

1997年 - 1998年

大阪大学医学部助教授
1997年 - 1998年

Osaka University Medical School, Associate
1991年 - 1997年

大阪大学医学部講師
1991年 - 1997年

Osaka University Medical School, Assistant
1980年 - 1991年

大阪大学医学部助手
1980年 - 1991年

Osaka University Medical School, Research
Professor
Assistant

学歴

論文

Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic functions

Naoya Hayakawa, Motoko Shiozaki, Masahiro Shibata, Masato Koike, Yasuo Uchiyama, Nariaki Matsuura, Takahiro Gotow

EUROPEAN JOURNAL OF CELL BIOLOGY 92(1) 30-43 2013年1月査読有り
Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice

Motoko Shiozaki, Naoya Hayakawa, Masahiro Shibata, Masato Koike, Yasuo Uchiyama, Takahiro Gotow

HISTOCHEMISTRY AND CELL BIOLOGY 136(4) 475-489 2011年10月査読有り
Very-High-Dose alpha-Tocopherol Supplementation Increases Blood Pressure and Causes Possible Adverse Central Nervous System Effects in Stroke-Prone Spontaneously Hypertensive Rats

Kaori Miyamoto, Motoko Shiozaki, Masahiro Shibata, Masato Koike, Yasuo Uchiyama, Takahiro Gotow

JOURNAL OF NEUROSCIENCE RESEARCH 87(2) 556-566 2009年2月査読有り
Phosphorylation of Highly Conserved Neurofilament Medium KSP Repeats Is Not Required for Myelin-Dependent Radial Axonal Growth

Michael L. Garcia, Mala V. Rao, Jiro Fujimoto, Virginia B. Garcia, Sameer B. Shah, John Crum, Takahiro Gotow, Yasuo Uchiyama, Mark Ellisman, Nigel A. Calcutt …

JOURNAL OF NEUROSCIENCE 29(5) 1277-1284 2009年2月査読有り
Sleeping beauty transposon-based phenotypic analysis of mice: Lack of Arpc3 results in defective trophoblast outgrowth

Kojiro Yae, Vincent W. Keng, Masato Koike, Kosuke Yusa, Michiyoshi Kouno, Yoshihiro Uno, Gen Kondoh, Takahiro Gotow, Yasuo Uchiyama, Kyoji Horie …

MOLECULAR AND CELLULAR BIOLOGY 26(16) 6185-6196 2006年8月査読有り
Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants

T Sasaki, T Gotow, M Shiozaki, F Sakaue, T Saito, JP Julien, Y Uchiyama, SI Hisanaga

HUMAN MOLECULAR GENETICS 15(6) 943-952 2006年3月査読有り
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)

M Koike, M Shibata, S Waguri, K Yoshimura, Tanida, I, E Kominami, T Gotow, C Peters, K von Figura, N Mizushima …

AMERICAN JOURNAL OF PATHOLOGY 167(6) 1713-1728 2005年12月査読有り
NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth

ML Garcia, CS Lobsiger, SB Shah, TJ Deerinck, J Crum, D Young, CM Ward, TO Crawford, T Gotow, Y Uchiyama …

JOURNAL OF CELL BIOLOGY 163(5) 1011-1020 2003年12月査読有り
PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells

S Yoshida, Y Kajimoto, T Yasuda, H Watada, Y Fujitani, H Kosaka, T Gotow, T Miyatsuka, Y Umayahara, Y Yamasaki …

DIABETES 51(8) 2505-2513 2002年8月査読有り

MISC

Phosphorylation of Highly Conserved Neurofilament Medium KSP Repeats Is Not Required for Myelin-Dependent Radial Axonal Growth

Michael L. Garcia, Mala V. Rao, Jiro Fujimoto, Virginia B. Garcia, Sameer B. Shah, John Crum, Takahiro Gotow, Yasuo Uchiyama, Mark Ellisman, Nigel A. Calcutt …

JOURNAL OF NEUROSCIENCE 29(5) 1277-1284 2009年2月
Very-High-Dose alpha-Tocopherol Supplementation Increases Blood Pressure and Causes Possible Adverse Central Nervous System Effects in Stroke-Prone Spontaneously Hypertensive Rats

Kaori Miyamoto, Motoko Shiozaki, Masahiro Shibata, Masato Koike, Yasuo Uchiyama, Takahiro Gotow

JOURNAL OF NEUROSCIENCE RESEARCH 87(2) 556-566 2009年2月
Hepatic gap junctions in the hepatocarcinogen-resistant DRH rat

Takahiro Gotow, Motoko Shiozaki, Taneaki Higashi, Kentaro Yoshimura, Masahiro Shibata, Eiki Kominami, Yasuo Uchiyama

HISTOCHEMISTRY AND CELL BIOLOGY 130(3) 583-594 2008年9月査読有り
Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

M. Shiozaki, K. Yoshimura, M. Shibata, M. Koike, N. Matsuura, Y. Uchiyama, T. Gotow

NEUROSCIENCE 152(4) 924-941 2008年4月
Neurons in the klotho mutant mouse show biochemical and morphological characteristics resembling age-related disorders

Takahiro Gotow

Tzu Chi Medical Journal 20(3) 155-160 2008年
Sleeping beauty transposon-based phenotypic analysis of mice: Lack of Arpc3 results in defective trophoblast outgrowth

Kojiro Yae, Vincent W. Keng, Masato Koike, Kosuke Yusa, Michiyoshi Kouno, Yoshihiro Uno, Gen Kondoh, Takahiro Gotow, Yasuo Uchiyama, Kyoji Horie …

MOLECULAR AND CELLULAR BIOLOGY 26(16) 6185-6196 2006年8月
Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants

T Sasaki, T Gotow, M Shiozaki, F Sakaue, T Saito, JP Julien, Y Uchiyama, SI Hisanaga

HUMAN MOLECULAR GENETICS 15(6) 943-952 2006年3月
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)

Masato Koike, Masahiro Shibata, Satoshi Waguri, Kentaro Yoshimura, Isei Tanida, Eiki Kominami, Takahiro Gotow, Christoph Peters, Kurt Von Figura, Noboru Mizushima …

American Journal of Pathology 167(6) 1713-1728 2005年
The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate

MV Rao, J Campbell, AD Yuan, A Kumar, T Gotow, Y Uchiyama, RA Nixon

JOURNAL OF CELL BIOLOGY 163(5) 1021-1031 2003年12月査読有り
NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth

ML Garcia, CS Lobsiger, SB Shah, TJ Deerinck, J Crum, D Young, CM Ward, TO Crawford, T Gotow, Y Uchiyama …

JOURNAL OF CELL BIOLOGY 163(5) 1011-1020 2003年12月
Mammalian Mcm2/4/6/7 complex forms a toroidal structure

N Yabuta, N Kajimura, K Mayanagi, M Sato, T Gotow, Y Uchiyama, Y Ishimi, H Nojima

GENES TO CELLS 8(5) 413-421 2003年5月
PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells

S Yoshida, Y Kajimoto, T Yasuda, H Watada, Y Fujitani, H Kosaka, T Gotow, T Miyatsuka, Y Umayahara, Y Yamasaki …

DIABETES 51(8) 2505-2513 2002年8月
Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport

MV Rao, ML Garcia, Y Miyazaki, T Gotow, AD Yuan, S Mattina, CM Ward, NA Calcutt, Y Uchiyama, RA Nixon …

JOURNAL OF CELL BIOLOGY 158(4) 681-693 2002年8月査読有り
Effects of desmin gene knockout on mice heart mitochondria

Journal of Bioenergetics and Biomembranes 33 173-199 2001年
Site-specific phosphorylation of neurofilament-L is mediated by calcium/calmodulin-dependent protein kinase II in the apical dendrites during long-term potentiation

R Hashimoto, Y Nakamura, S Komai, Y Kashiwagi, K Tamura, T Goto, S Aimoto, K Kaibuchi, S Shiosaka, M Takeda

JOURNAL OF NEUROCHEMISTRY 75(1) 373-382 2000年7月
Electron microscopic observation and single-stranded DNA binding activity of the Mcm4,6,7 complex

M Sato, T Gotow, ZY You, Y Komamura-Kohno, Y Uchiyama, N Yabuta, H Nojima, Y Ishimi

JOURNAL OF MOLECULAR BIOLOGY 300(3) 421-431 2000年7月
Selective localization of Bcl-2 to the inner mitochondrial and smooth endoplasmic reticulum membranes in mammalian cells

T Gotow, M Shibata, S Kanamori, O Tokuno, Y Ohsawa, N Sato, K Isahara, Y Yayoi, T Watanabe, JF Leterrier …

CELL DEATH AND DIFFERENTIATION 7(7) 666-674 2000年7月
Neurofilaments in health and disease

T. Gotow

Medical Electron Microscopy 33(4) 173-199 2000年
Abnormal expression of neurofilament proteins in dysmyelinating axons located in the central nervous system of jimpy mutant mice

T Gotow, JF Leterrier, Y Ohsawa, T Watanabe, K Isahara, R Shibata, K Ikenaka, Y Uchiyama

EUROPEAN JOURNAL OF NEUROSCIENCE 11(11) 3893-3903 1999年11月
Expression and polarized distribution of an inwardly rectifying K+ channel, Kir4.1, in rat retinal pigment epithelium

S Kusaka, Y Horio, A Fujita, K Matsushita, A Inanobe, T Gotow, Y Uchiyama, Y Tano, Y Kurachi

JOURNAL OF PHYSIOLOGY-LONDON 520(2) 373-381 1999年10月

もっとみる

所属学協会

Works(作品等)

低分子化学物質による細胞老化の機構の解析

2008年 - 2015年
神経変死におけるミトコンドリア及び植物化学物質の関与

1998年 - 2015年
遺伝子操作マウスにおけるニューロフィラメントの構築

2000年 - 2010年
Organization of Neurofilments in Transgenic Mice

2000年 - 2006年
Involvement of Mitochondria in Neurodegeneration

1998年 - 2004年
ニューロフィラメント間の相互作用の分子機構

1996年 - 1998年
Molecular Mechanism of Interactions between Neurofilaments

1996年 - 1998年

共同研究・競争的資金等の研究課題

植物化学物質による神経老化の抑制

基礎科学研究 2009年 - 2015年
Inhibition of neuronal senescence by phytochemicals

Basic Science Research Program 2008年 - 2015年
細胞変性および細胞死におけるミトコンドリアの役割

国際共同研究 2004年 - 2015年
神経細胞における中間径フィラメントの意義

国際共同研究 2000年 - 2015年
Functional significance of muscarinic acetylcholine receptors

International Joint Research Projects 2005年 - 2012年
Roles of mitochondria on the cell degeneration and death

International Joint Research Projects 2004年 - 2010年
Significance of intermediate filaments in the neuron

International Joint Research Projects 2000年 - 2010年