Misc.

Open access
2000

The class IV semaphorin CD100 plays nonredundant roles in the immune system: Defective B and T cell activation in CD100-deficient mice

Immunity
  • Wei Shi
  • Atsushi Kumanogoh
  • Chie Watanabe
  • Junji Uchida
  • Xiaosong Wang
  • Teruhito Yasui
  • Kazunori Yukawa
  • Masahito Ikawa
  • Masaru Okabe
  • Jane R. Parnes
  • Kanji Yoshida
  • Hitoshi Kikutani
  • Display all

Volume
13
Number
5
First page
633
Last page
642
Language
English
Publishing type
DOI
10.1016/S1074-7613(00)00063-7
Publisher
CELL PRESS

The class IV semaphorin CD100/Sema4D differentially utilizes two distinct receptors: plexin-B1 in nonlymphoid tissues, such as brain and kidney, and CD72 in lymphoid tissues. We have generated CD100-deficient mice and demonstrated that they have functional defects in their immune system, without apparent abnormalities in other tissues. The number of CD5+ B-1 cells was considerably decreased in the mutant mice, whereas conventional B cells and T cells appeared to develop normally. In vitro proliferative responses and immunoglobulin production were reduced in CD100-deficient B cells. The humoral immune response against a T cell-dependent antigen and in vivo priming of T cells were also defective in the mutant mice. These results demonstrate nonredundant and essential roles of CD100-CD72 interactions in the immune system.

Link information
DOI
https://doi.org/10.1016/S1074-7613(00)00063-7
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11114376
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000165598500006&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033634849&origin=inward Open access
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0033634849&origin=inward
ID information
  • DOI : 10.1016/S1074-7613(00)00063-7
  • ISSN : 1074-7613
  • Pubmed ID : 11114376
  • SCOPUS ID : 0033634849
  • Web of Science ID : WOS:000165598500006

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