2000
The class IV semaphorin CD100 plays nonredundant roles in the immune system: Defective B and T cell activation in CD100-deficient mice
Immunity
- Volume
- 13
- Number
- 5
- First page
- 633
- Last page
- 642
- Language
- English
- Publishing type
- DOI
- 10.1016/S1074-7613(00)00063-7
- Publisher
- CELL PRESS
The class IV semaphorin CD100/Sema4D differentially utilizes two distinct receptors: plexin-B1 in nonlymphoid tissues, such as brain and kidney, and CD72 in lymphoid tissues. We have generated CD100-deficient mice and demonstrated that they have functional defects in their immune system, without apparent abnormalities in other tissues. The number of CD5+ B-1 cells was considerably decreased in the mutant mice, whereas conventional B cells and T cells appeared to develop normally. In vitro proliferative responses and immunoglobulin production were reduced in CD100-deficient B cells. The humoral immune response against a T cell-dependent antigen and in vivo priming of T cells were also defective in the mutant mice. These results demonstrate nonredundant and essential roles of CD100-CD72 interactions in the immune system.
- Link information
-
- DOI
- https://doi.org/10.1016/S1074-7613(00)00063-7
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/11114376
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000165598500006&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033634849&origin=inward Open access
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0033634849&origin=inward
- ID information
-
- DOI : 10.1016/S1074-7613(00)00063-7
- ISSN : 1074-7613
- Pubmed ID : 11114376
- SCOPUS ID : 0033634849
- Web of Science ID : WOS:000165598500006