菊谷仁 (Hitoshi Kikutani) - マイポータル

基本情報

所属: 大阪大学微生物病研究所分子免疫制御分野教授

学位: 医学博士(大阪大学)

J-GLOBAL ID: 200901056981691761
researchmap会員ID: 1000030866

外部リンク: http://www.biken.osaka-u.ac.jp/biken/mol-imm/index.htm

研究分野

学歴

論文

148

Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection

Shuhei Sakakibara, Teruhito Yasui, Hideyuki Jinzai, Kristy O’Donnell, Chao Yuan Tsai, Takeharu Minamitani, Kazuya Takeda, Gabrielle T. Belz, David M. Tarlinton, Hitoshi Kikutani

International Immunology 32(1) 27-38 2020年1月1日査読有り
Allergic conversion of protective mucosal immunity against nasal bacteria in patients with chronic rhinosinusitis with nasal polyposis

Kazuya Takeda, Shuhei Sakakibara, Kazuo Yamashita, Daisuke Motooka, Shota Nakamura, Marwa Ali El Hussien, Jun Katayama, Yohei Maeda, Masanobu Nakata, Shigeyuki Hamada …

Journal of Allergy and Clinical Immunology 143(3) 1163-1175.e15 2019年3月査読有り
Bystander inhibition of humoral immune responses by Epstein-Barr virus LMP1

Chao Yuan Tsai, Shuhei Sakakibara, Teruhito Yasui, Takeharu Minamitani, Daisuke Okuzaki, Hitoshi Kikutani

International Immunology 30(12) 579-590 2018年査読有り
Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus

Shuhei Sakakibara, Takao Arimori, Kazuo Yamashita, Hideyuki Jinzai, Daisuke Motooka, Shota Nakamura, Songling Li, Kazuya Takeda, Jun Katayama, Marwa Ali El Hussien …

Scientific Reports 7(1) 16428 2017年12月1日査読有り
Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease

Takeharu Minamitani, Yijie Ma, Hufeng Zhou, Hiroshi Kida, Chao Yuan Tsai, Masanori Obana, Daisuke Okuzaki, Yasushi Fujio, Atsushi Kumanogoh, Bo Zhao …

Proceedings of the National Academy of Sciences of the United States of America 114(18) 4751-4756 2017年5月2日査読有り
The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in the Development of Allergic Airway Inflammation

Yusuke Yamazumi, Oh Sasaki, Mitsuru Imamura, Takeaki Oda, Yoko Ohno, Yumi Shiozaki-Sato, Shigenori Nagai, Saki Suyama, Yuki Kamoshida, Kosuke Funato …

Cell Reports 16(9) 2456-2471 2016年8月30日査読有り
Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A

Takeharu Minamitani, Teruhito Yasui, Yijie Ma, Hufeng Zhou, Daisuke Okuzaki, Chiau Yuang Tsai, Shuhei Sakakibara, Benjamin E. Gewurz, Elliott Kieff, Hitoshi Kikutani

Proceedings of the National Academy of Sciences of the United States of America 112(37) 11612-11617 2015年9月15日査読有り
Semaphorin 4D induces vaginal epithelial cell apoptosis to control mouse postnatal vaginal tissue remodeling

Takuji Ito, Tao Bai, Tetsuji Tanaka, Kenji Yoshida, Takashi Ueyama, Masayasu Miyajima, Takayuki Negishi, Takahiko Kawasaki, Hyota Takamatsu, Hitoshi Kikutani …

Molecular Medicine Reports 11(2) 829-836 2015年2月1日査読有り
Estrogen-dependent proteolytic cleavage of semaphorin 4D and plexin-B1 enhances semaphorin 4D-induced apoptosis during postnatal vaginal remodeling in pubescent mice

Takuji Ito, Tao Bai, Tetsuji Tanaka, Kenji Yoshida, Takashi Ueyama, Masayasu Miyajima, Takayuki Negishi, Takahiko Kawasaki, Hyota Takamatsu, Hitoshi Kikutani …

PLoS ONE 9(5) e97909 2014年5月19日査読有り
Plexin-A1 is required for Toll-like receptor-mediated microglial activation in the development of lipopolysaccharide-induced encephalopathy

Takuji Ito, Kenji Yoshida, Takayuki Negishi, Masayasu Miyajima, Hyota Takamatsu, Hitoshi Kikutani, Atsushi Kumanogoh, Kazunori Yukawa

International Journal of Molecular Medicine 33(5) 1122-1130 2014年5月査読有り
Protection against colitis by CD100-dependent modulation of intraepithelial γδ T lymphocyte function

T. F. Meehan, D. A. Witherden, C. H. Kim, K. Sendaydiego, I. Ye, O. Garijo, H. K. Komori, A. Kumanogoh, H. Kikutani, L. Eckmann …

Mucosal Immunology 7(1) 134-142 2014年1月査読有り
Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis

Satoru Tada, Tatsusada Okuno, Yasumichi Hitoshi, Teruhito Yasui, Josephe Archie Honorat, Kazushiro Takata, Toru Koda, Hiroshi Shimagami, Choong Chi-Jing, Akiko Namba …

Journal of Neuroinflammation 11(1) 179-186 2014年査読有り
Immunological functions of the neuropilins and plexins as receptors for semaphorins

Atsushi Kumanogoh, Hitoshi Kikutani

Nature Reviews Immunology 13(11) 802-814 2013年11月査読有り
Significance of glycosylphosphatidylinositol-anchored protein enrichment in lipid rafts for the control of autoimmunity

Yetao Wang, Yoshiko Murakami, Teruhito Yasui, Shigeharu Wakana, Hitoshi Kikutani, Taroh Kinoshita, Yusuke Maeda

Journal of Biological Chemistry 288(35) 25490-25499 2013年8月30日査読有り
BAFF Controls Neural Cell Survival through BAFF Receptor

Satoru Tada, Teruhito Yasui, Yuji Nakatsuji, Tatsusada Okuno, Toru Koda, Hideki Mochizuki, Saburo Sakoda, Hitoshi Kikutani

PLoS ONE 8(7) e70924 2013年7月29日査読有り
An inhibitory role for Sema4A in antigen-specific allergic asthma

Tetsuo Morihana, Sho Goya, Masayuki Mizui, Teruhito Yasui, Durubaka V.R. Prasad, Atsushi Kumanogoh, Manabu Tamura, Takashi Shikina, Yohei Maeda, Yoriko Iwamoto …

Journal of Clinical Immunology 33(1) 200-209 2013年査読有り
Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation

Teruhito Yasui, Kaori Sakakibara-Yada, Taki Nishimura, Kentaro Morita, Satoru Tada, George Mosialos, Elliott Kieff, Hitoshi Kikutani

Proceedings of the National Academy of Sciences of the United States of America 109(51) 21022-21027 2012年12月18日査読有り
The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function.

Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ, Verdino P, Wilson IA, Kumanogoh A, Kikutani H …

Immunity 37(2) 314-325 2012年8月24日査読有り
Neuroimmune semaphorin 4A downregulates the severity of allergic response

E. H. Nkyimbeng-Takwi, K. Shanks, E. Smith, A. Iyer, M. M. Lipsky, L. J. Detolla, H. Kikutani, A. D. Keegan, S. P. Chapoval

Mucosal Immunology 5(4) 409-419 2012年7月査読有り
Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor

Chigusa Nakahashi-Oda, Satoko Tahara-Hanaoka, Masamichi Shoji, Yasushi Okoshi, Takako Nakano-Yokomizo, Nobuhiro Ohkohchi, Teruhito Yasui, Hitoshi Kikutani, Shin ichiro Honda, Kazuko Shibuya …

Journal of Experimental Medicine 209(8) 1493-1503 2012年7月査読有り

もっとみる

MISC

Neuropilin-1: The Glue between Regulatory T Cells and Dendritic Cells?

Masayuki Mizui, Hitoshi Kikutani

Immunity 28(3) 302-303 2008年3月14日
Semaphorin signaling during cardiac development

Toshihiko Toyofuku, Hitoshi Kikutani

Advances in Experimental Medicine and Biology 600 109-117 2007年
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis

Noriko Takegahara, Hyota Takamatsu, Toshihiko Toyofuku, Tohru Tsujimura, Tatsusada Okuno, Kazunori Yukawa, Masayuki Mizui, Midori Yamamoto, Durbaka V.R. Prasad, Kazuhiro Suzuki …

Nature Cell Biology 8(6) 615-622 2006年6月
Semaphorins in the immune system

A. Kumanogoh, T. Shikina, K. Suzuki, M. Yamamoto, H. Takamatsu, N. Takegahara, S. Marukawa, I. Ishida, D. V.R. Prasad, T. Toyofuku …

International Congress Series 1285 202-206 2005年11月
Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2

Toshihiko Toyofuku, Hong Zhang, Atsushi Kumanogoh, Noriko Takegahara, Fumikazu Suto, Junko Kamei, Kazuhiro Aoki, Masanori Yabuki, Masatsugu Hori, Hajime Fujisawa …

Genes and Development 18(4) 435-447 2004年2月15日
Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D

A. Kumanogoh, H. Kikutani

Cellular and Molecular Life Sciences 61(3) 292-300 2004年2月
Semaphorins in interactions between T cells and antigen-presenting cells

Hitoshi Kikutani, Atsushi Kumanogoh

Nature Reviews Immunology 3(2) 159-167 2003年2月
Class iv semaphorin sema4a enhances t-cell activation and interacts with tim-2

Atsushi Kumanogoh, Satoko Marukawa, Kazuhiro Suzuki, Noriko Takegahara, Chie Watanabe, Ewe Seng Ch'ng, Isao Ishida, Harutoshi Fujimura, Saburo Sakoda, Kanji Yoshida …

Nature 419(6907) 629-633 2002年10月10日
The CD100-CD72 interaction: A novel mechanism of immune regulation

Atsushi Kumanogoh, Hitoshi Kikutani

Trends in Immunology 22(12) 670-676 2001年12月1日
Functional soluble CD100/sema4D released from activated lymphocytes: Possible role in normal and pathologic immune responses

Xiaosong Wang, Atsushi Kumanogoh, Chie Watanabe, Wei Shi, Kanji Yoshida, Hitoshi Kikutani

Blood 97(11) 3498-3504 2001年6月1日
Knocking the SOCS off a tumor suppressor

Tadamitsu Kishimoto, Hitoshi Kikutani

Nature Genetics 28(1) 4-5 2001年
Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: A role of CD40 in regulatory T cell development

A. Kumanogoh, X. Wang, I. Lee, C. Watanabe, M. Kamanaka, W. Shi, K. Yoshida, T. Sato, S. Habu, M. Itoh …

Journal of Immunology 166(1) 353-360 2001年1月1日
Genetic and immunological basis of autoimmune diabetes in the NOD mouse

K. Yoshida, H. Kikutani

Reviews in Immunogenetics 2(1) 140-146 2000年
The class IV semaphorin CD100 plays nonredundant roles in the immune system: Defective B and T cell activation in CD100-deficient mice

Wei Shi, Atsushi Kumanogoh, Chie Watanabe, Junji Uchida, Xiaosong Wang, Teruhito Yasui, Kazunori Yukawa, Masahito Ikawa, Masaru Okabe, Jane R. Parnes …

Immunity 13(5) 633-642 2000年
Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: A novel mechanism for regulating B cell signaling

Atsushi Kumanogoh, Chie Watanabe, Ihnsook Lee, Xiaosong Wang, Wei Shi, Hiroshi Araki, Haruhiko Hirata, Kota Iwahori, Junji Uchida, Teruhito Yasui …

Immunity 13(5) 621-631 2000年
Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses

Junji Uchida, Teruhito Yasui, Yuko Takaoka-Shichijo, Masaaki Muraoka, Wanla Kulwichit, Nancy Raab-Traub, Hitoshi Kikutani

Science 286(5438) 300-303 1999年10月8日
Regulation of B cell differentiation

H. Kikutani

Nippon rinsho. Japanese journal of clinical medicine 57(2) 262-266 1999年2月
CD40-deficient mice infected with the defective murine leukemia virus LP-BM5def do not develop murine AIDS but produce IgE and IgG1 in vivo

Philipp Yu, Renate A. Morawetz, Sisir Chattopadhyay, Masahiko Makino, Tadamitsu Kishimoto, Hitoshi Kikutani

European Journal of Immunology 29(2) 615-625 1999年
Dissection of immune responses utilizing CD40-deficient mice

H. Kikutani

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 43(2) 127-132 1998年2月
CD antigens 1996

T. Kishimoto, S. Goyert, H. Kikutani, D. Mason, M. Miyasaka, L. Moretta, T. Ohno, K. Okumura, S. Shaw, T. A. Springer …

Blood 89(10) 3502 1997年

もっとみる

書籍等出版物

Roles of the semaphorin family in immune regulation.

Adv. Immunol 2003年
The murine autoimmune diabetes model : NOD and related strains. In Advances in Immunology

Academic Press 1992年

所属学協会

共同研究・競争的資金等の研究課題

自己免疫疾患に関する研究

その他の研究制度
Bリンパ球表面分子の機能

その他の研究制度
Study on autoimmune diseases

The Other Research Programs
Study on functions of B Cell surface proteins

The Other Research Programs