2019年12月5日
A Hydroperoxide-Mediated Decarboxylation of α-Ketoacids Enables the Chemoselective Acylation of Amines
Chemistry - A European Journal
- ,
- ,
- ,
- 巻
- 25
- 号
- 68
- 開始ページ
- 15504
- 終了ページ
- 15507
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/chem.201904717
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Strategies for the formation of amide bonds, that is, one of the most basic and important transformations in organic synthesis, have so far focused predominantly on dehydration reactions. Herein, we report and demonstrate the practical utility of a novel decarboxylative amidation of α-ketoacids by using inexpensive tert-butyl hydroperoxide (TBHP), which is characterized by high yields, a broad substrate scope, mild reaction conditions, and a unique chemoselectivity. These features enable the synthesis of peptides from amino acid derived α-ketoacids under preservation of the stereochemical information.
- リンク情報
- ID情報
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- DOI : 10.1002/chem.201904717
- ISSN : 0947-6539
- eISSN : 1521-3765
- PubMed ID : 31631416
- SCOPUS ID : 85074766383