2013年6月
Synthetic study of perophoramidine: construction of pentacyclic core structure via SmI2-mediated reductive cyclization
TETRAHEDRON
- ,
- 巻
- 69
- 号
- 23
- 開始ページ
- 4517
- 終了ページ
- 4523
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.tet.2013.04.039
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
An intramolecular SmI2-mediated reductive cyclization of carbodiimides and unsaturated lactams was applied to functionalized substrates bearing tetrasubstituted olefins. The reaction afforded arylated spiro-2-iminoindolines in high yield. Although the stereochemistry of the product was different from the desired one, the optimized palladium-catalyzed aryl amidination realized the isomerization and C-N bond formation in a single step and resulted in efficient construction of pentacyclic core of perophoramidine synthetically equivalent to the Rainier's intermediate. (C) 2013 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.tet.2013.04.039
- ISSN : 0040-4020
- CiNii Articles ID : 120005244917
- Web of Science ID : WOS:000319028100002