Masaru Okabe

Profile Information

Affiliation: Professor, Research Institute for Microbial Diseases, Osaka University

Degree: (BLANK)(Osaka University)

J-GLOBAL ID: 200901000229664288
researchmap Member ID: 1000031460

Research Interests

Research Areas

Research History

Committee Memberships

Papers

NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility

Daiji Kiyozumi, Taichi Noda, Ryo Yamaguchi, Tomohiro Tobita, Takafumi Matsumura, Kentaro Shimada, Mayo Kodani, Takashi Kohda, Yoshitaka Fujihara, Manabu Ozawa …

Science, 368(6495) 1132-1135, Jun 5, 2020 Peer-reviewed
Reduction in BDNF from inefficient precursor conversion influences nest building and promotes depressive-like behavior in mice

Masami Kojima, Hikari Otabi, Haruko Kumanogoh, Atsushi Toyoda, Masahito Ikawa, Masaru Okabe, Toshiyuki Mizui

International Journal of Molecular Sciences, 21(11), Jun 1, 2020 Peer-reviewed
CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice

Yonggang Lu, Seiya Oura, Takafumi Matsumura, Asami Oji, Nobuyuki Sakurai, Yoshitaka Fujihara, Keisuke Shimada, Haruhiko Miyata, Tomohiro Tobita, Taichi Noda …

Biology of Reproduction, 101(2) 501-511, Aug 1, 2019 Peer-reviewed
Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies

Naoki Aoyama, Hiroyuki Miyoshi, Hitoshi Miyachi, Masahiro Sonoshita, Masaru Okabe, Makoto Mark Taketo

Genes to Cells, 23(7) 580-589, Jul 1, 2018 Peer-reviewed
The mechanics clarifying counterclockwise rotation in most IVF eggs in mice

Kenta Ishimoto, Masahito Ikawa, Masaru Okabe

Scientific Reports, 7 43456, Mar 3, 2017 Peer-reviewed
A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats^†

Ayako Isotani, Takafumi Matsumura, Masaki Ogawa, Takahiro Tanaka, Kazuo Yamagata, Masahito Ikawa, Masaru Okabe

Biology of Reproduction, 97(1) 61-68, 2017 Peer-reviewed
STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation

Ken Takashima, Yohei Takeda, Hiroyuki Oshiumi, Hiroaki Shime, Masaru Okabe, Masahito Ikawa, Misako Matsumoto, Tsukasa Seya

Biochemical and Biophysical Research Communications, 478(4) 1764-1771, Sep 30, 2016 Peer-reviewed
The behavior and acrosomal status of mouse spermatozoa in vitro, and within the oviduct during fertilization after natural mating

Toshiaki Hino, Yuko Muro, Miwa Tamura-Nakano, Masaru Okabe, Hiroyuki Tateno, Ryuzo Yanagimachi

Biology of Reproduction, 95(3), Sep 1, 2016 Peer-reviewed
Abnormal spermatogenesis and male infertility in testicular zinc finger protein Zfp318-knockout mice

Masamichi Ishizuka, Eri Ohtsuka, Atsuto Inoue, Mirei Odaka, Hirotaka Ohshima, Norihisa Tamura, Kaoru Yoshida, Norihisa Sako, Tadashi Baba, Shin ichi Kashiwabara …

Development Growth and Differentiation, 58(7) 600-608, Sep 1, 2016 Peer-reviewed
Live imaging of X chromosome reactivation dynamics in early mouse development can discriminate naïve from primed pluripotent stem cells

Shin Kobayashi, Yusuke Hosoi, Hirosuke Shiura, Kazuo Yamagata, Saori Takahashi, Yoshitaka Fujihara, Takashi Kohda, Masaru Okabe, Fumitoshi Ishino

Development (Cambridge), 143(16) 2958-2964, Aug 15, 2016 Peer-reviewed
Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice

Haruhiko Miyata, Julio M. Castaneda, Yoshitaka Fujihara, Zhifeng Yu, Denise R. Archambeault, Ayako Isotani, Daiji Kiyozumi, Maya L. Kriseman, Daisuke Mashiko, Takafumi Matsumura …

Proceedings of the National Academy of Sciences of the United States of America, 113(28) 7704-7710, Jul 12, 2016 Peer-reviewed
Behavior of mouse spermatozoa in the female reproductive tract from soon after mating to the beginning of fertilization

Yuko Muro, Hidetoshi Hasuwa, Ayako Isotani, Haruhiko Miyata, Kazuo Yamagata, Masahito Ikawa, Ryuzo Yanagimachi, Masaru Okabe

Biology of Reproduction, 94(4) 1-7, Apr, 2016 Peer-reviewed
Deficiency in WT1-targeting microRNA-125a leads to myeloid malignancies and urogenital abnormalities

N. Tatsumi, N. Hojo, O. Yamada, M. Ogawa, Y. Katsura, S. Kawata, E. Morii, H. Sakamoto, R. Inaba, A. Tsuda …

Oncogene, 35(8) 1003-1014, Feb 25, 2016 Peer-reviewed
Impaired female fertility in tubulointerstitial Antigen-Like 1-Deficient mice

Akihito Takahashi, Ajalli Rahim, Miki Takeuchi, Emiko Fukui, Midori Yoshizawa, Kuniaki Mukai, Makoto Suematsu, Hidetoshi Hasuwa, Masaru Okabe, Hiromichi Matsumoto

Journal of Reproduction and Development, 62(1) 43-49, Feb 20, 2016 Peer-reviewed
The acrosome reaction: A historical perspective

Masaru Okabe

Advances in Anatomy Embryology and Cell Biology, 220, 2016 Peer-reviewed
Calreticulin is required for development of the cumulus oocyte complex and female fertility

Keizo Tokuhiro, Yuhkoh Satouh, Kaori Nozawa, Ayako Isotani, Yoshitaka Fujihara, Yumiko Hirashima, Hiroyuki Matsumura, Kazuhiro Takumi, Takashi Miyano, Masaru Okabe …

Scientific Reports, 5 14254, Sep 21, 2015 Peer-reviewed
Mechanisms of fertilization elucidated by gene-manipulated animals

Masaru Okabe

Asian Journal of Andrology, 17(4) 646-652, Jul, 2015 Peer-reviewed
DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

Hiroyuki Oshiumi, Moeko Miyashita, Masaaki Okamoto, Yuka Morioka, Masaru Okabe, Misako Matsumoto, Tsukasa Seya

Cell Reports, 11(8) 1193-1207, May 26, 2015 Peer-reviewed
A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis

Hidenobu Okuda, Hiroshi Kiuchi, Tetsuya Takao, Yasushi Miyagawa, Akira Tsujimura, Norio Nonomura, Haruhiko Miyata, Masaru Okabe, Masahito Ikawa, Yoshitaka Kawakami …

PLoS ONE, 10(4) e0124293, Apr, 2015 Peer-reviewed
Activating transcription factor 5 is required for mouse olfactory bulb development via interneuron

Mariko Umemura, Kanako Tsunematsu, Yusuke I. Shimizu, Haruo Nakano, Shigeru Takahashi, Yasutomo Higashiura, Masaru Okabe, Yuji Takahashi

Bioscience, Biotechnology and Biochemistry, 79(7) 1082-1089, 2015 Peer-reviewed

Misc.

322

Haprin-deficient spermatozoa are incapable of in vitro fertilization

Yusuke Aoki, Akira Tsujimura, Kazuhiro Kaseda, Masaru Okabe, Keizo Tokuhiro, Tomoe Ohta, Moira K. O'Bryan, Hidenobu Okuda, Kouichi Kitamura, Yukiko Ogawa …

Molecular Reproduction and Development, 87(5) 534-541, May 1, 2020
Beware of memes in the interpretation of your results – lessons from gene-disrupted mice in fertilization research

Masaru Okabe

FEBS Letters, 592(16) 2673-2679, Aug, 2018
Sperm-egg interaction and fertilization: Past, present, and future

Masaru Okabe

Biology of Reproduction, 99(1) 134-146, 2018
Erratum: Real-time observation of acrosomal dispersal from mouse sperm using GFP as a marker protein (FEBS Lett. (1999) 449 (277-283))

Tomoko Nakanishi, Masahito Ikawa, Shuichi Yamada, Martti Parvinen, Tadashi Baba, Yoshitake Nishimune, Masaru Okabe

FEBS Letters, 589(20) 3220-3220, Oct 7, 2015
Mechanism of fertilization: A modern view

Masaru Okabe

Experimental Animals, 63(4) 357-365, 2014
Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes

Susumu Mitsutake, Kota Zama, Hazuki Yokota, Tetsuya Yoshida, Miki Tanaka, Masaru Mitsui, Masahito Ikawa, Masaru Okabe, Yoshikazu Tanaka, Tadashi Yamashita …

Journal of Biological Chemistry, 286(32) 28544-28555, Aug 12, 2011
Mechanisms of fertilization - A view from the study of gene-manipulated mice

Yuko Muro, Masaru Okabe

Journal of Andrology, 32(3) 218-225, May, 2011
A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice

Chikara Kokubu, Kyoji Horie, Koichiro Abe, Ryuji Ikeda, Sumi Mizuno, Yoshihiro Uno, Sanae Ogiwara, Masato Ohtsuka, Ayako Isotani, Masaru Okabe …

Nature Genetics, 41(8) 946-952, Aug, 2009
Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration

Makoto Nishizuka, Keishi Kishimoto, Ayumi Kato, Masahito Ikawa, Masaru Okabe, Ryuichiro Sato, Hiroyuki Niida, Makoto Nakanishi, Shigehiro Osada, Masayoshi Imagawa

Experimental Cell Research, 315(5) 809-819, Mar 10, 2009
Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration

Makoto Nishizuka, Keishi Kishimoto, Ayumi Kato, Masahito Ikawa, Masaru Okabe, Ryuichiro Sato, Hiroyuki Niida, Makoto Nakanishi, Shigehiro Osada, Masayoshi Imagawa

EXPERIMENTAL CELL RESEARCH, 315(5) 809-819, Mar, 2009
Genetic loss of Faah compromises male fertility in mice

Xiaofei Sun, Haibin Wang, Masaru Okabe, Kenneth Mackie, Philip J. Kingsley, Lawrence J. Marnett, Benjamin F. Cravatt, Sudhansu K. Dey

Biology of Reproduction, 80(2) 235-242, Feb, 2009
Genetic Loss of Faah Compromises Male Fertility in Mice

Xiaofei Sun, Haibin Wang, Masaru Okabe, Kenneth Mackie, Philip J. Kingsley, Lawrence J. Marnett, Benjamin F. Cravatt, Sudhansu K. Dey

BIOLOGY OF REPRODUCTION, 80(2) 235-242, Feb, 2009
Putative sperm fusion protein IZUMO and the role of N-glycosylation

Naokazu Inoue, Masahito Ikawa, Masaru Okabe

Biochemical and Biophysical Research Communications, 377(3) 910-914, Dec 19, 2008
Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus

Dong-Ye Youn, Dong-Hyoung Lee, Mi-Hyun Lim, Jung-Sook Yoon, Ji Hee Lim, Seung Eun Jung, Chung Eun Yeum, Cheol Whee Park, Ho-Joong Youn, Jae-Seon Lee …

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 295(6) E1349-E1357, Dec, 2008
Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus

Dong Ye Youn, Dong Hyoung Lee, Mi Hyun Lim, Jung Sook Yoon, Hee Lim Ji, Eun Jung Seung, Eun Yeum Chung, Whee Park Cheol, Ho Joong Youn, Jae Seon Lee …

American Journal of Physiology - Endocrinology and Metabolism, 295(6) E1349-E1357, Dec, 2008
Putative sperm fusion protein IZUMO and the role of N-glycosylation

Naokazu Inoue, Masahito Ikawa, Masaru Okabe

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 377(3) 910-914, Dec, 2008
Differential human serum-mediated neutralization of PERV released from pig cells transfected with variants of hDAF

Eiji Okura, Aiko Ishimaru, Aki Yamamoto, Shino Nakatsu, Ryota Shirakura, Masaru Okabe, Yoshiki Sawa, Masahiro Fukuzawa, Meinoshin Okumura, Shuji Miyagawa

Xenotransplantation, 15(6) 365-373, Nov, 2008
Differential human serum-mediated neutralization of PERV released from pig cells transfected with variants of hDAF

Eiji Okura, Aiko Ishimaru, Aki Yamamoto, Shino Nakatsu, Ryota Shirakura, Masaru Okabe, Yoshiki Sawa, Masahiro Fukuzawa, Meinoshin Okumura, Shuji Miyagawa

XENOTRANSPLANTATION, 15(6) 365-373, Nov, 2008
The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice

Kenji Miyado, Keiichi Yoshida, Kazuo Yamagata, Keiichi Sakakibara, Masaru Okabe, Xiaobiao Wang, Kiyoko Miyamoto, Hidenori Akutsu, Takahiko Kondo, Yuji Takahashi …

Proceedings of the National Academy of Sciences of the United States of America, 105(35) 12921-12926, Sep 2, 2008
The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice

Kenji Miyado, Keiichi Yoshida, Kazuo Yamagata, Keiichi Sakakibara, Masaru Okabe, Xiaobiao Wang, Kiyoko Miyamoto, Hidenori Akutsu, Takahiko Kondo, Yuji Takahashi …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(35) 12921-12926, Sep, 2008

Books and Other Publications

顕微鏡活用なるほどQ&A(共著)

羊土社, 2009 (ISBN: 9784758107310)
精子の受精能(共著)

改訂3版対外受精Update, 2001
遺伝子の発現と機能を解析する方法(共著)

臨床消化器内科6 消化器疾患の分子医学, 2001
精子学(共著)

東京大学出版会, 1992

Professional Memberships

Works

Research Projects

相同組換えによる遺伝子改変動物の作製と疾患モデルマウスの作製

その他の研究制度
疾患モデル動物の作成

科学研究費補助金
受精のメカニズムに関する研究

科学研究費補助金
Production of model animals for human diseases

Grant-in-Aid for Scientific Research
Study on Fertilization Mechanism

Grant-in-Aid for Scientific Research

Profile Information

Research Interests

Research Areas

Research History

Committee Memberships

Papers

Misc.

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