2009年2月
Genetic loss of Faah compromises male fertility in mice
Biology of Reproduction
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- 巻
- 80
- 号
- 2
- 開始ページ
- 235
- 終了ページ
- 242
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1095/biolreprod.108.072736
- 出版者・発行元
- SOC STUDY REPRODUCTION
Marijuana is the most commonly used illicit drug. Although there is some indication that reproductive functions in males are impaired in chronic marijuana users, the genetic evidence and underlying causes remain largely unknown. Herein we show that genetic loss of Faah, which encodes fatty acid amide hydrolase (FAAH), results in elevated levels of anandamide, an endocan- nabinoid, in the male reproductive system, leading to compromised fertilizing capacity of sperm. This defect is rescued by superimposing deletion of cannabinoid receptor 1 (Cnr1). Retention of Faah -/- sperm on the egg zona pellucida provides evidence that the capacity of sperm to penetrate the zona barrier is hampered by elevated anandamide levels. Collectively, the results show that aberrant endocannabinoid signaling via CNR1 impairs normal sperm function. Besides unveiling a new regulatory mechanism of sperm function, this study has clinical significance in male fertility. © 2009 by the Society for the Study of Reproduction, Inc.
- リンク情報
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- DOI
- https://doi.org/10.1095/biolreprod.108.072736
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/18987328
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000262603600004&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=59949100369&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=59949100369&origin=inward
- ID情報
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- DOI : 10.1095/biolreprod.108.072736
- ISSN : 0006-3363
- eISSN : 1529-7268
- PubMed ID : 18987328
- SCOPUS ID : 59949100369
- Web of Science ID : WOS:000262603600004