2013年5月14日
Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa
Proceedings of the National Academy of Sciences of the United States of America
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- 巻
- 110
- 号
- 20
- 開始ページ
- 8111
- 終了ページ
- 8116
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1073/pnas.1222166110
Formation of spermatozoa of normal shape, number, and motility is insufficient for the male siring of pups. The spermatozoa must be accompanied by sound fertilizing ability. We found that males with disrupted testis-expressed gene 101 (Tex101) produce normal-looking but fertilization-incompetent spermatozoa, which were accompanied by a deficiency of a disintegrin and metallopeptidase domain 3 (ADAM3) on sperm plasma membrane. It was also found that the existence of TEX101 on spermatozoa was regulated by angiotensin-converting enzyme (ACE). The removal of GPI-anchored protein TEX101 by ACE was essential to produce fertile spermatozoa, and the function of ACE was not depending on its well-known peptidase activity. The finding of TEX101 as a unique specific substrate for ACE may provide a potential target for the production of an awaited contraceptive medicine for men.
- リンク情報
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- DOI
- https://doi.org/10.1073/pnas.1222166110
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/23633567
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84877864049&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84877864049&origin=inward
- ID情報
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- DOI : 10.1073/pnas.1222166110
- ISSN : 0027-8424
- eISSN : 1091-6490
- PubMed ID : 23633567
- SCOPUS ID : 84877864049