藤原大美 (Hiromi Fujiwara) - マイポータル - researchmap

基本情報

所属: 旧所属大阪大学大学院医学系研究科分子病態医学専攻助教授

学位: 医学博士(大阪大学)

J-GLOBAL ID: 200901092967582816
researchmap会員ID: 1000031726

研究キーワード

2

研究分野

1

ライフサイエンス / 免疫学 /

学歴

2

- 1969年

大阪大学, 医学部, 医学
- 1969年

大阪大学

受賞

1

1984年

日本癌学会奨励賞

MISC

87

An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex

M Nakahira, M Tomura, M Iwasaki, HJ Ahn, Y Bian, T Hamaoka, T Ohta, M Kurimoto, H Fujiwara

JOURNAL OF IMMUNOLOGY 167(3) 1306-1312 2001年8月
IL-12 as well as IL-2 upregulates CCR5 expression on T cell receptor-triggered human CD4(+) and CD8(+) T cells

YF Yang, M Tomura, M Iwasaki, T Mukai, P Gao, S Ono, JP Zou, GM Shearer, H Fujiwara, T Hamaoka

JOURNAL OF CLINICAL IMMUNOLOGY 21(2) 116-125 2001年3月
A critical role for IL-12 in CCR5 induction on T cell receptor-triggered mouse CD4⁺ and CD8⁺ T cells.

Eur. J. Immunol. 31(8) 2411-2420 2001年
IFN-γ in tumor immunity : T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-γ-deficient mice.

Cancer Res. 61 3399-3405 2001年
CD28 costimulation is required not only to induce IL-12 receptor but also to render Janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells.

Eur. J. Immunol. 31(5) 1456-1464 2001年
Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression.

Int. Immunopharmacol. 1(4) 613-623 2001年
TGF-β upregulates CD40-engaged IL-12 production of mouse Langerhans cells.

Eur. J. Immunol. 31(1) 294-300 2001年
Differential effects of N-acetyl-L-cysteine on IL-2-vs IL-12-driven proliferation of a T cell clone: Implications for distinct signalling pathways

CS Park, WR Park, N Sugimoto, M Nakahira, HJ Ahn, T Hamaoka, T Ohta, M Kurimoto, H Fujiwara

CYTOKINE 12(9) 1419-1422 2000年9月
The development of peritumoral stroma required for IL-12 induced tumor regression depends on the T cell/IFN-gamma-involving host-tumor interaction

Y Uekusa, M Ogawa, P Gao, M Iwasaki, S Ono, T Tsujimura, M Nakazawa, M Sakuda, B Clancy, H Fujiwara …

INTERNATIONAL JOURNAL OF ONCOLOGY 16(4) 805-814 2000年4月
Requirement for IFN-γ in IL-12 production induced by collaboration between Vα14⁺ NKT cells and antigen-presenting cells.

Int. Immunol. 12(12) 1669-1675 2000年
Tumor vaccination enhancing anti-tumor T cell responses fails to inhibit the growth of established tumors even in combination with IL-12 treatment : Importance for inducing intratumoral T cell migration.

J. Immunother. 23 643-653 2000年
Fusogenic liposomes efficiently deliver exogenous antigen through the cytoplasm into the class I MHC processing pathway.

Eur. J. Immunol. 30(6) 1740-1747 2000年
Granulocyte/macrophage colony stimuration factor strongly inhibits interleukin 12 production of mouse Langerhans cells.

J. Immunol. 164 5113-5119 2000年
Interleukin-18 in combination with IL-12 enhances natural killer cell activity without inducing large amounts of IFN-γ in vivo.

J. Interferon Cytokine Res. 20(2) 217-224 2000年
Differential IL-12 responsiveness of T cells but not of NK cells from tumorbearing mice in IL-12-responsive vs-unresponsive tumor model.

Int. Immunol. 12(5) 701-709 2000年
Sublobular veins as the main site of lymphocyte adhesion/transmigration and adhesion molecule expression in the porto-sinusoidal-hepatic venous system during concanavalin A-induced hepatitis in mice

H Morikawa, K Hachiya, H Mizuhara, H Fujiwara, S Nishiguchi, S Shiomi, T Kuroki, K Kaneda

HEPATOLOGY 31(1) 83-94 2000年1月
CD5 costimulation upregulates the signaling to ERK activation in CD4⁺CD8⁺ thymocytes and supports their differentiation to the CD4 lineage.

J. Immunol. 164 1260-1268 2000年
Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of T cell receptor with rafts.

J. Immunol. 164 1251-1259 2000年
A novel function of V alpha 14(+)CD4(+)NKT cells: Stimulation of IL-12 production by antigen-presenting cells in the innate immune system

M Tomura, WG Yu, HJ Ahn, M Yamashita, YF Yang, S Ono, T Hamaoka, T Kawano, M Taniguchi, Y Koezuka …

JOURNAL OF IMMUNOLOGY 163(1) 93-101 1999年7月
A critical role for a peritumoral stromal reaction in the induction of T-cell migration responsible for interleukin-12-induced tumor regression

M Ogawa, K Umehara, WG Yu, Y Uekusa, C Nakajima, T Tsujimura, T Kubo, H Fujiwara, T Hamaoka

CANCER RESEARCH 59(7) 1531-1538 1999年4月

もっとみる

書籍等出版物

8

腫瘍免疫学（第２版）

中外医学社 2003年
新移植免疫学

中外医学社 2000年
Transplantation Immunology

2000年
Tumor Immunology

1998年
T細胞系の免疫学(改訂3版)

中外医学社 1997年
Immunology of T Lineage Cells

1997年
免疫研究法ハンドブック

中外医学社 1992年
Handbook for Immunological Research

1992年

所属学協会

3

共同研究・競争的資金等の研究課題

6