KATAOKA Tohru

J-GLOBAL         Last updated: Sep 13, 2019 at 02:40
 
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Name
KATAOKA Tohru
Affiliation
Kobe University
Section
Institute of Promoting Academic Research Programs Office for Academic and Industrial Innovation (OACIS)
Job title
Professor

Research Areas

 
 

Awards & Honors

 
Nov 2009
ras癌遺伝子産物の機能の解明とそれを標的とした抗癌剤の開発研究を通じた医学の発展への貢献, 兵庫県科学賞, 兵庫県
Winner: Kataoka Tohru
 
Oct 2007
医学・分子生物学四分野での独創的かつ世界的な研究成果, 井植文化賞, 井植記念会
Winner: KATAOKA TOHRU
 
Oct 2007
兵庫県在住の個人・団体または特に兵庫県にゆかりの深い個人・団体。各分野で前年度、とくにめざましい活躍をし、かつ、多大な貢献をした個人・団体, 第31回井植文化賞(科学技術部門), 財団法人井植記念会
Winner: Kataoka Tohru
 
Mar 1981
免疫グロブリン遺伝子の構造変換と発現の機構に関する研究成果, 日本分子生物学会研究奨励賞(第1回), 日本分子生物学会
Winner: KATAOKA TOHRU
 

Published Papers

 
UMEZAWA KANOKO, NAGANO TATSUYA, KOBAYASHI KAZUYUKI, DOKUNI RYOTA, KATSURADA MASAHIRO, YAMAMOTO MASATSUGU, YOSHIKAWA YOKO, KATAOKA TOHRU, NISHIMURA YOSHIHIRO
Respiratory Research   20(9) 1-12   Jan 2019   [Refereed]
Background: We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and inflammation-associated carcinogenesis by augmenting proinflammatory cytokine production from epithelial cel...
Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring.
Matsumoto S, Hiraga T, Hayashi Y, Yoshikawa Yoko, Tsuda C, Araki M, Neya M, SHIMA FUMI, Kataoka Tohru
Biochemistry   57(36) 5350-5358   Sep 2018   [Refereed]
MAETA KAZUHIRO, HATTORI SATOKO, IKUTOMO JUNJI, EDAMATSU HIRONORI, BILASY SHYMAA E, MIYAKAWA TSUYOSHI, KATAOKA TOHRU
Molecular Brain   11(27) 1-22   May 2018   [Refereed]
Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain. Previous genomic analyses suggested their possible involvement in the etiology ...
Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1α pathway
Yoshikawa Yoko, TakanoO, KatoI, TakahashiY, Shima Fumi, Kataoka Tohru
Cancer Lett   410 82-91   Dec 2017   [Refereed]
Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression
FaragMI, Yoshikawa Yoko, MaetaK, Kataoka Tohru
Biochem Biophys Res Commun   493(1) 139-145   Nov 2017   [Refereed]

Misc

 
Current status of the development of Ras inhibitors
Shima Fumi, MatsumotoS, Yoshikawa Yoko, Kawamura Takashi, Isa Masayuki, Kataoka Tohru
J Biochem   158(2) 91-9   Aug 2015   [Refereed]
rasがん遺伝子産物Rasを分子標的としたがん治療薬開発の現状
島 扶美, 吉川 陽子, 松本 篤幸, Kataoka Tohru
がん分子標的治療   13(1) 92-98   Apr 2015   [Invited]
rasがん遺伝子産物の新規立体構造情報を利用した分子標的がん治療薬の開発
Shima Fumi, 熊坂崇, Matsumoto Shigeyuki, Yoshikawa Yoko, 山本雅貴, Kataoka Tohru
日本放射光学会誌 放射光   27(1) 3-9   2014   [Refereed]
Phospholipase Cε as a potential molecular target for anti-inflammatory therapy and cancer prevention
Edamatsu Hironori, Kataoka Tohru
Inflammation and regeneration.   Vol. 31, No. 4, pp. 370-374    Sep 2011   [Refereed]
Multiple roles of phosphoinositide-specific phospholipase C isozymes
Kataoka Tohru
BMB reports   Vol. 41, No. 6, pp. 415-34    Jun 2008

Books etc

 
ras がん遺伝子産物 Ras を分子標的としたがん治療薬開発の現状
SHIMA FUMI, Matsumoto Shigeyuki, Yoshikawa Yoko, Kataoka Tohru (Part:Joint Work)
がん分子標的治療   2015   
SPring-8 Research Frontiers 2013 / Structure-based drug design of small-molecule Ras inhibitors having anti-tumor activity
Shima F, Kataoka Tohru
Japan Synchrotron Radiation Institute   Aug 2014   
The Enzymes, Vol. 34, Inhibitors of the Ras superfamily G-proteins, Part B / Discovery of Small-Molecule Ras Inhibitors that Display Antitumor Activity by Interfering with Ras・GTP?Effector Interaction
Yoshikawa Yoko, Matsumoto Shigeyuki, Kataoka Tohru
Elsevier Inc.   Dec 2013   
次世代がん戦略研究Update がん基盤生物学 革新的シーズ育成に向けて / がん微小環境を制御するRas/Rap標的タンパク質PLCεの選択的阻害剤の開発
Edamatsu Hironori, Kataoka Tohru
南山堂   Oct 2013   

Conference Activities & Talks

 
Development of anti-cancer drugs targeting the ras oncogne products [Invited]
KATAOKA TOHRU
理研シンポジウム「第4回DMP(創薬・医療技術基盤プログラム)創薬ワークショップ」   Nov 2018   理化学研究所創薬・医療技術基盤プログラム
rasがん遺伝子 (H-ras, K-ras, N-ras) は、がん全体の約20%において突然変異による恒常的活性化が見られることから、その産物Ras蛋白質はがん治療薬開発にとって恰好の分子標的である。しかし、その既知の高次構造の分子表面に薬剤結合ポケットが存在しないことから、Ras本体は”undruggable”とされ、その翻訳後修飾を標的とするファルネシル転移酵素阻害剤 (FTI) の開発も不首尾に終ったことから、革新的なアイデアが求められていた。Rasは低分子量G蛋白質の一員であり...
Conformational changes on GTP hydrolysis of oncogene product Ras as revealed by monitoring of time-dependent NMR signal using caged-GTP
HAGIHARA CHIKA, MAKINO YOSHITERU, KAWAMURA TAKASHI, NANGO ERIKO, KUMASAKA TAKSHI, MORI  ICHIRO, KATAOKA TOHRY, SHIMA FUMI
The 56th Annual Meeting of The Biophysical Society of Japan   Sep 2018   
Specific inhibitors of phospholipase Cepsilon (PLCepsilon) display anti-tumor and cancer-preventive effects as well as anti-inflammatory effect. [Invited]
KATAOKA TOHRU
IUBMB Seoul 2018   Jun 2018   International Union of Biochemistry and Molecular Biology
It is well known that chronic inflammation plays crucial roles in the pathogenesis of various diseases including cancer. Phospholipase Cepsilon (PLCepsilon) was discovered by us in 2001 as a novel class of PLC regulated by not only Ras and Rap1 sm...
ブレオマイシン誘導肺線維症マウスモデルにおけるPLCεの役割
桂田 雅大, NAGANO TATSUYA, EDAMATSU HIRONORI, UMEZAWA KANOKO, 堂國 良太, 安田 裕一郎, YAMAMOTO MASATSUGU, KOBAYASHI KAZUYUKI, KATAOKA TOHRU, NISHIMURA YOSHIHIRO
第58回日本呼吸器学会学術講演会   Apr 2018   
Development of Anti-Cancer and Anti-Inflammatory Drugs Targeting Phospholipase Cε
Yoshikawa Yoko, Naoto Fujishima, Aki Emi, Ning Ma, Masayuki Isa, Edamatsu Hironori, Kataoka Tohru
2018 Keystone Symposia Conference   Feb 2018   

Teaching Experience

 
 

Patents

 
特許6014816 : Ras機能阻害作用を有するチオキソチアゾリジン誘導体
KATAOKA TOHRU, SHIMA FUMI
US9056862 : Ras機能阻害作用を有するチオキソチアゾリジン誘導体(アメリカ)
KATAOKA TOHRU, SHIMA FUMI