Journal of Biomechanical Science and Engineering 9 Jan 2014
In this study, for a better understanding of arterial functions, we examine the effects of active stresses, which are generated by contractile units included in smooth muscle cells, on the stress distribution in the arterial wall. Thus far, it is ...
Journal of Nanoscience and Nanotechnology 14 5654-5657 Jan 2014
Actin filaments play essential roles in many kinds of cellular functions by interacting with hundreds of actin binding proteins. Here we probe the interaction between actin filament and a binding protein, α-actinin, using an atomic force microscop...
Journal of Biological Chemistry 287 12217-12229 Apr 2012
Cell surface heparan sulfate (HS) is an essential regulator of cell signaling and development. HS traps signaling molecules, like Wnt in the glycosaminoglycan side chains of HS proteoglycans (HSPGs), and regulates their functions. Endosulfatases S...
The generation of complex organ structures such as the eye requires the intricate orchestration of multiple cellular interactions. In this paper, early retinal development is discussed with respect to the structure formation of the optic cup. Alth...
Rearrangement Dynamics of Contractile Actomyosin Network.
Yasuhiro Inoue and Taiji Adachi
10th World Congress on Computational Mechanics（WCCM2012）（2012.7.8－13．Sao Paulo, Brazil） 2012 [Refereed]
Mechanical Regulation of Actin Network Dynamnics in Migrating Cells（From Cells to Molecules）．
The mesoscopic stress and strain states of Bi2223/Ag/Ag-alloy superconducting composite tapes have been studied both analytically and experimentally under bending deformation. The tapes used in the present study were supplied as the standard sampl...
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A 76 111-119 Aug 2010
Actin filament, the most abundant component of the cytoskeleton, plays important roles in fundamental cellular activities by dynamically changing its structure by elongation, branching, and bundling. These dynamic structural changes are regulated ...
Contributions \nof Actin Cytoskeleton and Cell-substrate Adhesion in Control of Cell Motile Behavior in Microtopographical \nEnvironments.
Hiromi Miyoshi, Taiji Adachi, Jungmyoung Ju, Sang Min Lee, Dong Jin Cho, Jong Soo Ko, Yutaka Yamagata
Scott J. Hollister, Chia Ying Lin, Heesuk Kang, Taiji Adachi
Virtual Prototyping and Bio Manufacturing in Medical Applications 113-127 Dec 2008
The primary goals of tissue engineering scaffolds are to: o Provide guidance for anatomical tissue shape/volume o Provide temporary function within the tissue defect o Enhance tissue regeneration through mass transport and biologic delivery To ach...
M. Hojo; K. Nakashima; T. Kusaka; M. Tanaka; T. Adachi; T. Fukuoka; M. Ishibashi
17th European Conference on Fracture 2008: Multilevel Approach to Fracture of Materials, Components and Structures 3 2167-2174 Dec 2008
Zanchor is a novel through-thickness reinforcement technique where in-plane yarns are entangled each other by sticking with a special needle. Modes I and II interlaminar fracture toughness was investigated for carbon fiber (CF)/epoxy cross ply lam...
7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010 1 27-30 Jan 2010
Interfacial fracture behavior for GF/epoxy model composites was investigated under static and fatigue loadings using the bifiber shear (BFS) and the bifiber open (BFO) methods. Two E-glass fiber filaments (diameter: 23 or 40 μm) were bonded with b...
Remodeling Simulation Estimates Changes in Mechanical Properties \nof Osteoporotic Bone.
Daisuke Tawara, Ken Nagura, Taiji Adachi
18th Congress of the European Society of Biomechanics（ESB2012）（2012.7.1－4．Lisbon, Portugal） 2012 [Refereed]
Upregulation of Actomyosin Contractility Enhances Mechanical Integrity of Actin \nCytoskeleton in Lamellipodia
Taiji Adachi, Kennedy O. Okeyo
18th Congress of the European Society of Biomechanics（ESB2012）（2012.7.1 －4．Lisbon, Portugal） 2012 [Refereed]
Poroelastic Analysis of Interstitial Fluid Flow in Trabecula under Cyclic Loading.
Yoshitaka Kameo, Taiji Adachi
18th Congress of the European Society of Biomechanics（ESB2012）（2012.7.1－4 Lisbon, Portugal） 2012 [Refereed]
Y. Aonuma; T. Adachi; M. Tanaka; M. Hojo; T. Takano-Yamamoto; H. Kamioka
IFMBE Proceedings 23 2000-2004 Dec 2009
It is proposed that osteocytes embedded in mineralized bone matrix play a role in mechanosensory system during bone remodeling for mechanical adaptation. Various experimental and computer simulation approaches have revealed that the osteocytes sen...
Modeling and Simulation of Myosindependent \nRearrangement and Force Generation in an Actomyosin Network
Yasuhiro Inoue, Shunsuke Tsuda, Koji Nakagawa, Masaki Hojo, Taiji Adachi
Biophysical Society 56th Annual Meeting（2012.2.25－29．San Diego, U.S.A．） 2012 [Refereed]
M. Tanaka; H. Tanaka; M. Hojo; T. Adachi; M. Sugihara; M. Kotera; T. Nishino
ICCM International Conferences on Composite Materials Dec 2009
The interface-control for HAp/PLLA composite was tried in order to improve the bonding strength. The effects of interface control on deformation and fracture properties of HAp/PLLA composites were evaluated using three-point bending tests. The eff...
Molecular Dynamics Analysis of Coupling Behaviors between Extension \nand Torsion of Actin Filaments Micro-Structured Surfaces
Shinji Matsushita, Yasuhiro Inoue, Taiji Adachi
Biophysical Society 56th Annual Meeting （2012.2.25－29．San Diego, U.S.A.） 2012 [Refereed]
M. Hojo; Y. Yoshida; M. Sugano; T. Adachi; Y. Inoue; K. Shikimachi; N. Hirano; S. Nagaya
ICCM International Conferences on Composite Materials Dec 2009
We carried out fatigue tests of YBCO high-temperature superconducting coated conductor with Hastelloy substrate and additional Cu layer in LN 2, together with the measurement of the critical current. The addition of a Cu layer increased the fatigu...
Role \nof Actin Cytoskeletal Structure and Cell-Substrate Adhesion for Cell Migration on Micro-Structured Surfaces.
Hiromi Miyoshi, Jungmyoung Ju, Sang Min Lee, Dong Jin Cho, Jong Soo Ko, Taiji Adachi, Yutaka Yamagata
Biophysical Society 56th Annual Meeting（2012.2.25－29．San Diego, U.S.A.） 2012 [Refereed]
Shukei Sugita, Taiji Adachi, Yosuke Ueki, Masaaki Sato
Biophysical Journal 101 53-60 Jul 2011
The distribution of contractile forces generated in cytoskeletal stress fibers (SFs) contributes to cellular dynamic functions such as migration and mechanotransduction. Here we describe a novel (to our knowledge) method for measuring local tensio...
Balanced organogenesis requires the orchestration of multiple cellular interactions to create the collective cell behaviours that progressively shape developing tissues. It is currently unclear how individual, localized parts are able to coordinat...
Microscale Fluid-flow Analysis in Osteocyte Canaliculi Using High-resolution \nImage-based Models.
Hiroshi Kamioka, Yoshitaka Kameo, Yuichi Imai, Astrid D. Bakker, Rommel G Bacabac, Takashi Yamashiro, Taiji Adachi, Jenneke Klein-Nulend
American Society of Bone and Mineral Research（2011.9.16-21 San Diego, USA）. 2011 [Refereed]
Estimation of Changes in Mechanical Properties of Trabecular \nBone by Remodeling.
Daisuke Tawara, Takeshi Horikawa, Taiji Adachi
2011 World Congress on Advances in Structural Engineering and Mechanics（ASEM 11）（2011.9.18-23 Seoul, Korea）. 2011 [Refereed]
A Hypothesis of Structural Optimality in Bone: Modeling \nOsteocyte Network as a Mechanosensory System
Taiji Adachi, Yoshitaka Kameo, Ken-ichi Tsubota
11th US National Congress on Computational Mechanics （USNCCM-11）（2011.7.25-29 Minneapolis, USA） 2011 [Refereed]
It is essential to investigate the mechanical behaviour of cytoskeletal actin filaments in order to understand their critical role as mechanical components in various cellular functional activities. These actin filaments consisting of monomeric mo...
Clinical Reviews in Bone and Mineral Metabolism 8 170-178 Dec 2010
In a variety of scientific fields, it is helpful to visualize natural phenomena. Newly developed methods of visualization often lead to breakthroughs in scientific fields. Especially, in the bioscience field, it is significant to reveal temporal-s...
M. Hojo, K. Osawa, T. Adachi, Y. Inoue, K. Osamura, S. Ochiai, N. Ayai, K. Hayashi
Physica C: Superconductivity and its Applications 470 1373-1376 Nov 2010
Tensile strain tolerance of the critical current in (Bi,Pb) 2 Sr 2 Ca 2 Cu 3 O x (Bi2223) composite superconductor is dramatically improved when the tape is laminated with stainless steel. For practical applications, it is important to understand ...
Computers in Biology and Medicine 40 876-882 Nov 2010
A mechanochemical relationship between intracellular flow fields of actin and remodeling of actin filaments is important to the realization of cell motility. In this study, to investigate this mechanochemical relationship, we present a mathematica...
Geometrical settings of directed medium by vector bundle description and its \napplication to biomechanics.
Hidetaka Yamaoka, Taiji Adachi
47th Annual Technical Meeting of Society of Engineering Science（2010.10.04－06 Ames, USA） Oct 2010 [Refereed]
Journal of Biomechanical Science and Engineering 5 186-207 Aug 2010
Cell migration is fundamental to various physiological processes, including metastasis, wound healing and tissue development. The complex processes involved in cell migration; polymerization, adhesion, and retraction, are mediated by highly orches...
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368 2669-2682 Jun 2010
In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system are believed to play important roles in the mechanosensory system. Under dynamic loading, bone matrix deformation generates an interstitial.uid.ow in the lac...
Bio-Medical Materials and Engineering 20 55-63 May 2010
Condensation/aggregation process of rabbit-derived chondrocytes on a fibroin-coated patterned substrate was observed to estimate initial aggregation process in fibroin sponge. Chondrocytes were seeded on array of 160 μm diameter pits in three dens...
Journal of the Mechanical Behavior of Biomedical Materials 3 240-248 Apr 2010
Load-induced interstitial fluid flow in lacuno-canalicular porosity is believed to play an important role in cellular activities regulating adaptive bone remodeling. To investigate interstitial fluid behavior based on poroelasticity, it is importa...
M. Hojo, M. Mizuno, T. Hobbiebrunken, T. Adachi, M. Tanaka, S. K. Ha
Plastics, Rubber and Composites 39 99-106 Mar 2010
A detailed numerical investigation has been carried out to investigate the effect of local fibre array irregularities on microscopic interfacial normal stress for transversely loaded unidirectional carbon fibre/epoxy composites with random fibre a...
MCB Molecular and Cellular Biomechanics 6 161-173 Aug 2009
The actin filament, which is the most abundant component of the cytoskeleton, plays important roles in fundamental cellular activities such as shape determination, cell motility, and mechanosensing. In each activity, the actin filament dynamically...
Poromechanics IV - 4th Biot Conference on Poromechanics 77-82 Jan 2009
We present an analytical solution of interstitial fluid pressure in poroelastic materials subjected to cyclic axial and bending loading. The analytical solution contains transient and steady-state responses. Both of them depend on three dimensionl...
Composites Science and Technology 68 2678-2689 Oct 2008
Interfacial fracture behavior for GF/epoxy model composites was investigated under static loading using the bifiber shear (BFS) and the bifiber open (BFO) methods. Two E-glass fiber filaments were bonded with bisphenol A type epoxy. The specimens ...
Zairyo/Journal of the Society of Materials Science, Japan 57 868-874 Sep 2008
In the aim of tissue regeneration of an alveolar bone, we developed three-dimensional fabric structural composite scaffolds using a bioabsorbable polymer. This scaffold consists of a polylactic acid (PLLA) resin fiber and a 75/25 poly L-lactide-co...
Journal of the Mechanics and Physics of Solids 56 1794-1805 May 2008
Poroelasticity is a theory that quantifies the time-dependent mechanical behavior of a fluid-saturated porous medium induced by the interaction between matrix deformation and interstitial fluid flow. Based on this theory, we present an analytical ...
Journal of the Mechanical Behavior of Biomedical Materials 1 43-50 Jan 2008
Biochemical signals related to a mechanosensory mechanism by which cells sense mechanical stimuli have been gradually clarified by biological approaches such as blocking specific signaling pathways; however, mechanical signals such as deformation/...
Nippon Kinzoku Gakkaishi/Journal of the Japan Institute of Metals 72 57-62 Jan 2008
Two-dimensional quantitative analysis of microbeam X-ray diffraction (XRD) was performed using a transmission optical system to examine biological apatite (BAp) orientation in an isolated trabecula of a human fourth lumber vertebral body. The inci...
Osteocytes embedded in bone matrix, making a three-dimensional network system connected each other via cell processes, are considered as the mechanosensor cells that play important roles in the regulatory mechanism of adaptive bone remodeling. Thr...
M. Hojo, M. Nakamura, M. Tanaka, T. Adachi, M. Sugano, S. Ochiai, K. Osamura
Materials Science Forum 539-543 919-924 Dec 2007
The strain dependence of the critical current, Ic, of Bi2223/Ag/Ag-alloy composite superconducting tapes has been studied both experimentally and analytically under bending deformation for two types of tape used in the VAMAS bending round-robin pr...
M. Hojo, M. Hashimoto, M. Tanaka, T. Adachi, M. Sugano, S. Ochiai, K. Osamura
Physica C: Superconductivity and its Applications 463-465 863-866 Oct 2007
Young's modulus and fracture strain of Bi2223 filaments in Bi2223/Ag/Ag alloy composite tape were investigated in detail. Tensile tests were carried out for composite tapes from which Ag alloy component was completely removed by immersing the tape...
In adaptive bone remodeling, it is believed that bone cells such as osteoblasts, osteocytes and osteoclasts can sense mechanical stimuli and modulate their remodeling activities. However, the mechanosensing mechanism by which these cells sense mec...
Two-dimensional quantitative analysis of microbeam X-ray diffraction (XRD) was performed using a transmission optical system to examine biological apatite (BAp) orientation in an isolated trabecula of a human fourth lumber vertebral body. The inci...
Thomas Hobbiebrunken, Masaki Hojo, Taiji Adachi, Claas De Jong, Bodo Fiedler
Composites Part A: Applied Science and Manufacturing 37 2248-2256 Dec 2006
A combined experimental and numerical study has been carried out in order to study the mechanism of initial failure in transversely loaded CF/epoxy composites. Two composites with a high and a low temperature-curing matrix were investigated. Three...
Taiji Adachi, Yuki Osako, Mototsugu Tanaka, Masaki Hojo, Scott J. Hollister
Biomaterials 27 3964-3972 Jul 2006
In bone tissue engineering using a biodegradable scaffold, geometry of the porous scaffold microstructure is a key factor for controlling mechanical function of the bone-scaffold system in the regeneration process as well as after the regeneration...
International Journal of Fatigue 28 1154-1165 Jan 2006
Interlaminar fracture toughness and delamination fatigue crack growth behavior were investigated for carbon fiber (CF)/epoxy laminates with the self-same epoxy interleaf. The matrix epoxy with a thickness of 50 μm was chosen as the interleaf mater...
In order to study the temporal and regional variation of lightning occurrences and their relation to sprite activity and climate variability, we have analysed the 1-100 Hz ELF magnetic field waveform data obtained at the Syowa station in Antarctic...
Modelling osteocyte signalling in bone tissue adaptation.
Taiji Adachi, Yoshitaka, Kameo, Masaki Hojo
World Congress on Biomechanics（WCB2010）（2010.8.1－6 Singapore）（Invited Talk） 2010 [Refereed]
Multiscale simulation of trabecular bone adaptation by remodeling \ntoward understanding Wolff’s law.
Taiji Adachi, Yoshitaka Kameo, Masaki Hojo
The 9th World Congress on Computational Mechanics and 4th Asian Pacific Congress on Computational Mechanics（WCCM/APCOM2010）（2010.7.19－23 Sydney, Australia）（Keynote Talk） 2010 [Refereed]
Trabecular \nsurface remodeling simulation in human proximal femur using large-scale voxel FE models: Approach to \nunderstanding Wolff’s law.
JSME International Journal, Series 1: Solid Mechanics, Strength of Materials 35 170-178 Apr 1992
Gas flow in the airway and lung deformation due to tissue elasticity and surface tension are the main characteristics of respiratory dynamics. In this study, a simulation with the discretized model as a distributed parameter system is used extensi...
Tensile force suppresses torsional \nmotions of individual actin subunits
Modeling of osteocyte mechanosensing and communication in bone adaptation.
Taiji Adachi
Symposium : Cellular Mechanics in Embryogenesis, 43rd Annual Meeting for the Japanese Society of Developmental Biologists （2010.06.20－23 Kyoto） Jun 2010 [Refereed]
Biomechanics of actin cytoskeleton : in vitro and in silico studies
Interaction Measurement of Actin Filament and Actin Binding Protein Using \nan AFM.XIII.
Sung-Woong Han, Taiji Adachi
Annual Linz Winter Workshop Advances in Single-Molecule Research for Biology & Nanoscience（2011.2.4-7 Linz, Switzerland） 2011 [Refereed]
Quantitative analysis of the responses of migratory cells to microstructured surfaces
Hiromi Miyoshi,Jungmyoung Ju,Yutaka Yamagata,Sang Min Lee,Dong Jin Cho,Jong Soo Ko,Taiji Adachi
第63回日本細胞生物 学会（2011.6.27-29 札幌） 2011 [Refereed]
Mathematical Modeling of Trabecular Bone Remodeling Induced by Osteocytic \nResponse to Interstitial Fluid Flow
Yoshitaka Kameo, Taiji Adachi
8th European Conference on Mathematical and Theoretical Biology, and Annual Meeting of the Society for Mathematical Biology（ECMTB2011）（2011.6.28-7.2 Krakow, Poland）. 2011 [Refereed]
Extension-torsion Coupling Behavior of Single Actin Filament.
Workshop: Microscale Modeling in Biomechanics and Mechanobiology（2011.5.30-6.1 Ericeira, Prtugal）（Invited Talk） 2011 [Refereed]
Computer Simulation of Bone Remodeling and Regeneration for Porous Scaffold Design.
Taiji Adachi
International Conference on Tissue Engineering（ICTE2011）（2011.6.2-4 Lisbon, Portugal）（Keynote） 2011 [Refereed]
Poroelastic Modelling of Trabecular Bone Adaptation Stimulated \nby Flow-induced Shear Stress on Osteocytic Process Membrane in Lacuno-canalicular System.
Taiji Adachi, Yoshitaka Kameo, Masaki Hojo
IV International Conference on Computational Methods for Coupled Problems in Science and Engineering （Coupled Problem 2011）（2011.6.20-22 Kos Island, Greece）（Keynote Lecture） 2011 [Refereed]
Effect of Tension on the Stiffness of Actin \nFilaments.
S. Patriche; S. Matsushita; M. Banu; B.I. Epureanu; T. Adachi
Proceedings of SPIE - The International Society for Optical Engineering 23 May 2011
This work is concerned with the dynamics of motor proteins. In particular, we discuss the development of computational analysis tools for predicting the dynamics of molecular motors such as certain types of kinesin. The ability to model and predic...
