安達 泰治

J-GLOBALへ         更新日: 19/06/23 17:02
 
アバター
研究者氏名
安達 泰治
 
アダチ タイジ
URL
http://www.frontier.kyoto-u.ac.jp/bf05/membersHP/adachi/
所属
京都大学
部署
ウイルス・再生医科学研究所
職名
教授
学位
博士(工学)(大阪大学)
ORCID ID
0000-0001-5280-4156

研究分野

 
 

経歴

 
2016年10月
 - 
現在
京都大学 ウイルス・再生医科学研究所 教授
 
2013年4月
 - 
2016年9月
京都大学 再生医科学研究所 副所長
 
2010年4月
 - 
2016年9月
京都大学 再生医科学研究所 教授
 
2006年4月
 - 
2011年3月
理化学研究所 細胞シミュレーションチーム チームリーダー
 
2004年4月
 - 
2010年3月
京都大学 大学院工学研究科 准教授(助教授)
 
1998年4月
 - 
2004年3月
神戸大学 工学部 助教授
 
1992年4月
 - 
1998年3月
神戸大学 工学部 助手
 
1997年
 - 
1999年
ミシガン大学 特別研究員
 
1998年
 - 
1999年
日本学術振興会 海外特別研究員
 
1999年
   
 
- 理化学研究所 客員研究員
 
2000年
 - 
2001年
岡山大学 非常勤講師
 
2002年
 - 
2002年
名古屋大学 非常勤講師
 
2003年
 - 
2004年
京都大学 非常勤講師
 

学歴

 
 
 - 
1992年
大阪大学 基礎工学研究科 物理系専攻機械工学分野
 

受賞

 
1994年
日本機械学会 奨励賞(研究) (JSME Young Investigator Award (Research) )
 
2000年
日本機械学会バイオエンジニアリング部門 瀬口賞(JSME Bioengineering Division, Seguchi Award)
 
2001年
日本エム・イー学会科学新聞賞・研究奨励賞・阪本研究刊行助成賞・阿部賞(JSMBE Young Investigator Award )
 
1995年
NCP研究会 瀬口フロンティア賞(NCP, Seguchi Frontier Award)
 
2001年
日本機械学会材料力学部門講演会M&M2001優秀講演賞
 

論文

 
Masamu Inoue, Takehito Ono, Yoshitaka Kameo, Fumiyuki Sasaki, Takashi Ono, Taiji Adachi, Tomoki Nakashima
Scientific Reports   9    2019年12月
© 2019, The Author(s). Bone undergoes a constant reconstruction process of resorption and formation called bone remodeling, so that it can endure mechanical loading. During food ingestion, masticatory muscles generate the required masticatory forc...
Atsushi Matsuda, Jing Li, Peter Brumm, Taiji Adachi, Yasuhiro Inoue, Taeyoon Kim
Biophysical Journal   116 2161-2171   2019年6月
© 2019 Biophysical Society Cells generate mechanical forces primarily from interactions between F-actin, cross-linking proteins, myosin motors, and other actin-binding proteins in the cytoskeleton. To understand how molecular interactions between ...
Shunsuke Kawai, Hiroyuki Yoshitomi, Junko Sunaga, Cantas Alev, Sanae Nagata, Megumi Nishio, Masataka Hada, Yuko Koyama, Maya Uemura, Kazuya Sekiguchi, Hirotsugu Maekawa, Makoto Ikeya, Sakura Tamaki, Yonghui Jin, Yuki Harada, Kenichi Fukiage, Taiji Adachi, Shuichi Matsuda, Junya Toguchida
Nature Biomedical Engineering      2019年1月
© 2019, The Author(s), under exclusive licence to Springer Nature Limited. The recapitulation of bone formation via the in vitro generation of bone-like nodules is frequently used to understand bone development. However, current bone-induction tec...
S. Okuda, N. Takata, Y. Hasegawa, M. Kawada, Y. Inoue, T. Adachi, Y. Sasai, M. Eiraku
Science Advances   4    2018年11月
Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Organogenesis is a self-organizing process of multiple cells in three-dimensional (3D) space, where macroscopic tissue defo...
Stefania Marcotti, Koichiro Maki, Gwendolen C. Reilly, Damien Lacroix, Taiji Adachi
PLoS ONE   13    2018年10月
© 2018 Marcotti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ar...
Satoru Okuda, Takashi Miura, Yasuhiro Inoue, Taiji Adachi, Mototsugu Eiraku
SCIENTIFIC REPORTS   8(1)    2018年6月   [査読有り]
Tomoyasu Shinoda, Arata Nagasaka, Yasuhiro Inoue, Ryo Higuchi, Yoshiaki Minami, Kagayaki Kato, Makoto Suzuki, Takefumi Kondo, Takumi Kawaue, Kanako Saito, Naoto Ueno, Yugo Fukazawa, Masaharu Nagayama, Takashi Miura, Taiji Adachi, Takaki Miyata
PLoS Biology   16    2018年4月
© 2018 Shinoda et al. Neural progenitor cells (NPCs), which are apicobasally elongated and densely packed in the developing brain, systematically move their nuclei/somata in a cell cycle–dependent manner, called interkinetic nuclear migration (IKN...
Tomoyasu Shinoda, Arata Nagasaka, Yasuhiro Inoue, Ryo Higuchi, Yoshiaki Minami, Kagayaki Kato, Makoto Suzuki, Takefumi Kondo, Takumi Kawaue, Kanako Saito, Naoto Ueno, Yugo Fukazawa, Masaharu Nagayama, Takashi Miura, Taiji Adachi, Takaki Miyata
PLOS BIOLOGY   16(4)    2018年4月   [査読有り]
Satoru Okuda, Takashi Miura, Yasuhiro Inoue, Taiji Adachi, Mototsugu Eiraku
SCIENTIFIC REPORTS   8(1)    2018年2月   [査読有り]
Taiji Adachi, Yoshitaka Kameo
CISM International Centre for Mechanical Sciences, Courses and Lectures   578 231-257   2018年1月
© 2018, CISM International Centre for Mechanical Sciences. In bone remodeling, a variety of mechanical and biochemical signaling occurs among osteoclasts and osteoblasts, which are responsible for bone resorption and formation, and osteocytes, whi...

Misc

 
Taiji Adachi, Yoshitaka Shimada, Yasuhiro Inoue, Masaki Hojo
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A   76 111-119   2010年8月
Actin filament, the most abundant component of the cytoskeleton, plays important roles in fundamental cellular activities by dynamically changing its structure by elongation, branching, and bundling. These dynamic structural changes are regulated ...
Masaki Hojo, Yukinobu Matsushita, Mototsugu Tanaka, Taiji Adachi
7th Asian-Australasian Conference on Composite Materials 2010, ACCM 2010   1 27-30   2010年1月
Interfacial fracture behavior for GF/epoxy model composites was investigated under static and fatigue loadings using the bifiber shear (BFS) and the bifiber open (BFO) methods. Two E-glass fiber filaments (diameter: 23 or 40 μm) were bonded with b...
M. Tanaka, H. Tanaka, M. Hojo, T. Adachi, M. Sugihara, M. Kotera, T. Nishino
ICCM International Conferences on Composite Materials      2009年12月
The interface-control for HAp/PLLA composite was tried in order to improve the bonding strength. The effects of interface control on deformation and fracture properties of HAp/PLLA composites were evaluated using three-point bending tests. The eff...
M. Hojo, Y. Yoshida, M. Sugano, T. Adachi, Y. Inoue, K. Shikimachi, N. Hirano, S. Nagaya
ICCM International Conferences on Composite Materials      2009年12月
We carried out fatigue tests of YBCO high-temperature superconducting coated conductor with Hastelloy substrate and additional Cu layer in LN 2, together with the measurement of the critical current. The addition of a Cu layer increased the fatigu...
Sung Woong Han, Sung Woong Han, Kyohei Morita, Kyohei Morita, Taiji Adachi, Taiji Adachi
Science of Advanced Materials   6 2453-2458   2014年1月
© 2014 by American Scientific Publishers. Actin filament senses mechanical forces and it is transduced into biochemical signals during many cellular processes. In bending of actin filaments, actin-related protein 2/3 (Arp2/3) complex plays a centr...
Y. Aonuma, T. Adachi, T. Adachi, M. Tanaka, M. Hojo, T. Takano-Yamamoto, H. Kamioka
IFMBE Proceedings   23 2000-2004   2009年12月
It is proposed that osteocytes embedded in mineralized bone matrix play a role in mechanosensory system during bone remodeling for mechanical adaptation. Various experimental and computer simulation approaches have revealed that the osteocytes sen...
Yoshitaka Kameo, Taiji Adachi
Acta Mechanica   225 2833-2840   2014年1月
© 2014, Springer-Verlag Wien. Cancellous bone has a complicated three-dimensional porous microstructure that consists of strut-like or plate-like trabeculae. The arrangement of the trabeculae is remodeled throughout the organism’s lifetime to func...
Scott J. Hollister, Chia Ying Lin, Heesuk Kang, Taiji Adachi
Virtual Prototyping and Bio Manufacturing in Medical Applications   113-127   2008年12月
The primary goals of tissue engineering scaffolds are to: o Provide guidance for anatomical tissue shape/volume o Provide temporary function within the tissue defect o Enhance tissue regeneration through mass transport and biologic delivery To ach...
Mototsugu Tanaka, Hidekazu Tanaka, Masaki Hojo, Taiji Adachi, Suong Hyu Hyon, Masakazu Konda
8th World Biomaterials Congress 2008   2 805   2008年12月
Masaki Hojo, Masaaki Mizuno, Thomas Hobbiebrunken, Thomas Hobbiebrunken, Mototsugu Tanaka, Taiji Adachi, Sung Kyu Ha
Advanced Composites for Efficiency and Environment - The US-Japan Conference on Composite Materials 2008, US-Japan 2008      2008年12月
Taiji Adachi, Naoki Kida
Journal of Biomechanical Science and Engineering   9    2014年1月
In this study, for a better understanding of arterial functions, we examine the effects of active stresses, which are generated by contractile units included in smooth muscle cells, on the stress distribution in the arterial wall. Thus far, it is ...
Masaki Hojo, Mitsuhiro Nakamura, Mototsugu Tanaka, Taiji Adachi, Michinaka Sugano, Shojiro Ochiai, Kozo Osamura
Superconductor Science and Technology   18    2005年12月
The mesoscopic stress and strain states of Bi2223/Ag/Ag-alloy superconducting composite tapes have been studied both analytically and experimentally under bending deformation. The tapes used in the present study were supplied as the standard sampl...
Katsuya Sato, Taiji Adachi, Masaki Hojo, Yoshihiro Tomita
Proceedings of the 2005 Summer Bioengineering Conference   2005 217-218   2005年12月
Masaki Hojo, Masaki Hojo, Kyosei Nakashima, Takayuki Kusaka, Mototsugu Tanaka, Taiji Adachi, Toshiyasu Fukuoka, Masayasu Ishibashi
17th European Conference on Fracture 2008: Multilevel Approach to Fracture of Materials, Components and Structures   3 2167-2174   2008年12月
Zanchor is a novel through-thickness reinforcement technique where in-plane yarns are entangled each other by sticking with a special needle. Modes I and II interlaminar fracture toughness was investigated for carbon fiber (CF)/epoxy cross ply lam...
Sung Woong Han, Sung Woong Han, Kyohei Morita, Patriche Simona, Patriche Simona, Takanori Kihara, Jun Miyake, Mihaela Banu, Taiji Adachi, Taiji Adachi
Journal of Nanoscience and Nanotechnology   14 5654-5657   2014年1月
Actin filaments play essential roles in many kinds of cellular functions by interacting with hundreds of actin binding proteins. Here we probe the interaction between actin filament and a binding protein, α-actinin, using an atomic force microscop...
Hiromi Miyoshi, Taiji Adachi
Tissue Engineering - Part B: Reviews   20 609-627   2014年1月
© 2014, Mary Ann Liebert, Inc. The physiological role of the actin cytoskeleton is well known: it provides mechanical support and endogenous force generation for formation of a cell shape and for migration. Furthermore, a growing number of studies...
Satoru Hayano, Hiroshi Kurosaka, Takeshi Yanagita, Ina Kalus, Fabian Milz, Yoshihito Ishihara, Md Nurul Islam, Noriaki Kawanabe, Masahiro Saito, Hiroshi Kamioka, Taiji Adachi, Thomas Dierks, Takashi Yamashiro
Journal of Biological Chemistry   287 12217-12229   2012年4月
Cell surface heparan sulfate (HS) is an essential regulator of cell signaling and development. HS traps signaling molecules, like Wnt in the glycosaminoglycan side chains of HS proteoglycans (HSPGs), and regulates their functions. Endosulfatases S...
Mototsugu Eiraku, Mototsugu Eiraku, Taiji Adachi, Taiji Adachi, Yoshiki Sasai, Yoshiki Sasai
BioEssays   34 17-25   2012年1月
The generation of complex organ structures such as the eye requires the intricate orchestration of multiple cellular interactions. In this paper, early retinal development is discussed with respect to the structure formation of the optic cup. Alth...
骨構造の階層性と機能的適応:数理生体力学
安達泰治
西安交通大学特別講義(2012.12.10.西安,中国)(特別講義)      2012年   [査読有り]
Shukei Sugita, Taiji Adachi, Yosuke Ueki, Masaaki Sato
Biophysical Journal   101 53-60   2011年7月
The distribution of contractile forces generated in cytoskeletal stress fibers (SFs) contributes to cellular dynamic functions such as migration and mechanotransduction. Here we describe a novel (to our knowledge) method for measuring local tensio...
Mototsugu Eiraku, Nozomu Takata, Hiroki Ishibashi, Masako Kawada, Eriko Sakakura, Satoru Okuda, Kiyotoshi Sekiguchi, Taiji Adachi, Yoshiki Sasai
Nature   472 51-58   2011年4月
Balanced organogenesis requires the orchestration of multiple cellular interactions to create the collective cell behaviours that progressively shape developing tissues. It is currently unclear how individual, localized parts are able to coordinat...
Shinji Matsushita, Taiji Adachi, Yasuhiro Inoue, Masaki Hojo, Masahiro Sokabe
Journal of Biomechanics   43 3162-3167   2010年12月
It is essential to investigate the mechanical behaviour of cytoskeletal actin filaments in order to understand their critical role as mechanical components in various cellular functional activities. These actin filaments consisting of monomeric mo...
Hiroshi Kamioka, Taiji Adachi
Clinical Reviews in Bone and Mineral Metabolism   8 170-178   2010年12月
In a variety of scientific fields, it is helpful to visualize natural phenomena. Newly developed methods of visualization often lead to breakthroughs in scientific fields. Especially, in the bioscience field, it is significant to reveal temporal-s...
M. Hojo, K. Osawa, T. Adachi, Y. Inoue, K. Osamura, S. Ochiai, N. Ayai, K. Hayashi
Physica C: Superconductivity and its Applications   470 1373-1376   2010年11月
Tensile strain tolerance of the critical current in (Bi,Pb) 2 Sr 2 Ca 2 Cu 3 O x (Bi2223) composite superconductor is dramatically improved when the tape is laminated with stainless steel. For practical applications, it is important to understand ...
Yasuhiro Inoue, Takeji Deji, Yoshitaka Shimada, Masaki Hojo, Taiji Adachi
Computers in Biology and Medicine   40 876-882   2010年11月
A mechanochemical relationship between intracellular flow fields of actin and remodeling of actin filaments is important to the realization of cell motility. In this study, to investigate this mechanochemical relationship, we present a mathematica...
Kennedy Omondi Okeyo, Taiji Adachi, Masaki Hojo
Journal of Biomechanical Science and Engineering   5 186-207   2010年8月
Cell migration is fundamental to various physiological processes, including metastasis, wound healing and tissue development. The complex processes involved in cell migration; polymerization, adhesion, and retraction, are mediated by highly orches...
Taiji Adachi, Yoshitaka Kameo, Masaki Hojo
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences   368 2669-2682   2010年6月
In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system are believed to play important roles in the mechanosensory system. Under dynamic loading, bone matrix deformation generates an interstitial.uid.ow in the lac...
Naoyoshi D. Kachi, Akihisa Otaka, Seungwoo Sim, Yoshihiko Kuwana, Yasushi Tamada, Junko Sunaga, Taiji Adachi, Naohide Tomita
Bio-Medical Materials and Engineering   20 55-63   2010年5月
Condensation/aggregation process of rabbit-derived chondrocytes on a fibroin-coated patterned substrate was observed to estimate initial aggregation process in fibroin sponge. Chondrocytes were seeded on array of 160 μm diameter pits in three dens...
Yoshitaka Kameo, Taiji Adachi, Narumichi Sato, Masaki Hojo
Journal of the Mechanical Behavior of Biomedical Materials   3 240-248   2010年4月
Load-induced interstitial fluid flow in lacuno-canalicular porosity is believed to play an important role in cellular activities regulating adaptive bone remodeling. To investigate interstitial fluid behavior based on poroelasticity, it is importa...
M. Hojo, M. Mizuno, T. Hobbiebrunken, T. Adachi, M. Tanaka, S. K. Ha
Plastics, Rubber and Composites   39 99-106   2010年3月
A detailed numerical investigation has been carried out to investigate the effect of local fibre array irregularities on microscopic interfacial normal stress for transversely loaded unidirectional carbon fibre/epoxy composites with random fibre a...
Yoshitaka Shimada, Taiji Adachi, Yasuhiro Inoue, Masaki Hojo
MCB Molecular and Cellular Biomechanics   6 161-173   2009年8月
The actin filament, which is the most abundant component of the cytoskeleton, plays important roles in fundamental cellular activities such as shape determination, cell motility, and mechanosensing. In each activity, the actin filament dynamically...
Y. Kameo, T. Adachi, M. Hojo
Poromechanics IV - 4th Biot Conference on Poromechanics   77-82   2009年1月
We present an analytical solution of interstitial fluid pressure in poroelastic materials subjected to cyclic axial and bending loading. The analytical solution contains transient and steady-state responses. Both of them depend on three dimensionl...
M. Sato, Y. Takahashi, A. Yoshida, T. Adachi
Journal of Physics D: Applied Physics   41    2008年12月
In order to study the temporal and regional variation of lightning occurrences and their relation to sprite activity and climate variability, we have analysed the 1-100 Hz ELF magnetic field waveform data obtained at the Syowa station in Antarctic...
Masaki Hojo, Yukinobu Matsushita, Mototsugu Tanaka, Taiji Adachi
Composites Science and Technology   68 2678-2689   2008年10月
Interfacial fracture behavior for GF/epoxy model composites was investigated under static loading using the bifiber shear (BFS) and the bifiber open (BFO) methods. Two E-glass fiber filaments were bonded with bisphenol A type epoxy. The specimens ...
Chiaki Hiwa, Kumiko Yokota, Yoshikazu Nakai, Nobuo Tanaka, Toshiyuki Imoto, Taiji Adachi, Masaki Hojo, Shunsuke Baba
Zairyo/Journal of the Society of Materials Science, Japan   57 868-874   2008年9月
In the aim of tissue regeneration of an alveolar bone, we developed three-dimensional fabric structural composite scaffolds using a bioabsorbable polymer. This scaffold consists of a polylactic acid (PLLA) resin fiber and a 75/25 poly L-lactide-co...
Yoshitaka Kameo, Taiji Adachi, Masaki Hojo
Journal of the Mechanics and Physics of Solids   56 1794-1805   2008年5月
Poroelasticity is a theory that quantifies the time-dependent mechanical behavior of a fluid-saturated porous medium induced by the interaction between matrix deformation and interstitial fluid flow. Based on this theory, we present an analytical ...
Taiji Adachi, Katsuya Sato, Norio Higashi, Yoshihiro Tomita, Masaki Hojo
Journal of the Mechanical Behavior of Biomedical Materials   1 43-50   2008年1月
Biochemical signals related to a mechanosensory mechanism by which cells sense mechanical stimuli have been gradually clarified by biological approaches such as blocking specific signaling pathways; however, mechanical signals such as deformation/...
Sayaka Miyabe, Takayoshi Nakano, Takuya Ishimoto, Naoki Takano, Taiji Adachi, Hiroyoshi Iwaki, Akio Kobayashi, Kunio Takaoka, Yukichi Umakoshi
Nippon Kinzoku Gakkaishi/Journal of the Japan Institute of Metals   72 57-62   2008年1月
Two-dimensional quantitative analysis of microbeam X-ray diffraction (XRD) was performed using a transmission optical system to examine biological apatite (BAp) orientation in an isolated trabecula of a human fourth lumber vertebral body. The inci...
Taiji Adachi
Clinical calcium   18 342-346   2008年1月
Osteocytes embedded in bone matrix, making a three-dimensional network system connected each other via cell processes, are considered as the mechanosensor cells that play important roles in the regulatory mechanism of adaptive bone remodeling. Thr...
M. Hojo, M. Nakamura, M. Tanaka, T. Adachi, M. Sugano, S. Ochiai, K. Osamura
Materials Science Forum   539-543 919-924   2007年12月
The strain dependence of the critical current, Ic, of Bi2223/Ag/Ag-alloy composite superconducting tapes has been studied both experimentally and analytically under bending deformation for two types of tape used in the VAMAS bending round-robin pr...
M. Hojo, M. Hashimoto, M. Tanaka, T. Adachi, M. Sugano, S. Ochiai, K. Osamura
Physica C: Superconductivity and its Applications   463-465 863-866   2007年10月
Young's modulus and fracture strain of Bi2223 filaments in Bi2223/Ag/Ag alloy composite tape were investigated in detail. Tensile tests were carried out for composite tapes from which Ag alloy component was completely removed by immersing the tape...
Katsuya Sato, Taiji Adachi, Daisuke Ueda, Masaki Hojo, Yoshihiro Tomita
Journal of Biomechanics   40 1246-1255   2007年3月
In adaptive bone remodeling, it is believed that bone cells such as osteoblasts, osteocytes and osteoclasts can sense mechanical stimuli and modulate their remodeling activities. However, the mechanosensing mechanism by which these cells sense mec...
Sayaka Miyabe, Takayoshi Nakano, Takuya Ishimoto, Naoki Takano, Taiji Adachi, Hiroyoshi Iwaki, Akio Kobayashi, Kunio Takaoka, Yukichi Umakoshi
Materials Transactions   48 343-347   2007年3月
Two-dimensional quantitative analysis of microbeam X-ray diffraction (XRD) was performed using a transmission optical system to examine biological apatite (BAp) orientation in an isolated trabecula of a human fourth lumber vertebral body. The inci...
T. Adachi, K. Sato, M. Hojo, Y. Tomita
Biomechanics at Micro- and Nanoscale Levels   49-59   2007年1月
© 2007 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. In bone functional adaptation by remodeling, it is recognized that bone cells can sense mechanical stimuli and modulate their activities. However, the mechanosensory mechanis...
Thomas Hobbiebrunken, Masaki Hojo, Taiji Adachi, Claas De Jong, Bodo Fiedler
Composites Part A: Applied Science and Manufacturing   37 2248-2256   2006年12月
A combined experimental and numerical study has been carried out in order to study the mechanism of initial failure in transversely loaded CF/epoxy composites. Two composites with a high and a low temperature-curing matrix were investigated. Three...
Taiji Adachi, Yuki Osako, Mototsugu Tanaka, Masaki Hojo, Scott J. Hollister
Biomaterials   27 3964-3972   2006年7月
In bone tissue engineering using a biodegradable scaffold, geometry of the porous scaffold microstructure is a key factor for controlling mechanical function of the bone-scaffold system in the regeneration process as well as after the regeneration...
Masaki Hojo, Tadashi Ando, Mototsugu Tanaka, Taiji Adachi, Shojiro Ochiai, Yoshihiro Endo
International Journal of Fatigue   28 1154-1165   2006年1月
Interlaminar fracture toughness and delamination fatigue crack growth behavior were investigated for carbon fiber (CF)/epoxy laminates with the self-same epoxy interleaf. The matrix epoxy with a thickness of 50 μm was chosen as the interleaf mater...
T. Adachi, K. Sato
Biomechanics at Micro- and Nanoscale Levels   2 51-61   2006年1月
© 2006 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. In reorganization process of the actin stress fibers, a change in its mechanical condition has been suggested as one of the key mediators. Some experimental studies have clar...
M. Hojo, M. Nakamura, M. Tanaka, T. Adachi, M. Sugano, S. Ochiai, K. Osamura
Physica C: Superconductivity and its Applications   426-431 1205-1210   2005年10月
The strain dependence of the critical current, Ic, of Bi2223/Ag/Ag-alloy composite superconducting tapes has been studied both experimentally and analytically under bending deformation. The microscopic observation after bending deformation indicat...
Katsuya Sato, Taiji Adachi, Mamoru Matsuo, Yoshihiro Tomita
Journal of Biomechanics   38 1895-1901   2005年9月
The cytoskeletal stress fiber structure plays essential roles in various kinds of cellular functions such as shape maintenance, active motility and mechanosensing, and its structure is dynamically reorganized under each functional process. In know...
Ken Ichi Tsubota, Taiji Adachi
Medical Engineering and Physics   27 305-311   2005年1月
A computer simulation of trabecular surface remodeling was carried out to investigate the spatial and temporal regulation of the cancellous bone structure caused by bone cellular activities responding to a local mechanical environment. In the remo...
Taiji Adachi
Seimitsu Kogaku Kaishi/Journal of the Japan Society for Precision Engineering   71 1483-1487   2005年1月
T. Adachi, K. Sato
Biomechanics at Micro- and Nanoscale Levels: Volume I   55-64   2005年1月
© 2005 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. Osteoblasts play an important role in adaptive bone remodeling under the influence of local mechanical signals such as stress/strain due to loading/deformation. However, the ...
Ken Ichi Tsubota, Taiji Adachi
Computer Methods in Biomechanics and Biomedical Engineering   7 187-192   2004年12月
Fabric and compliance tensors of a cube of cancellous bone with a complicated three-dimensional trabecular structure were obtained for trabecular surface remodeling by using a digital image-based model combined with a large-scale finite element me...
M. Hojo, T. Matsuoka, M. Nakamura, M. Tanaka, T. Adachi, S. Ochiai, K. Miyashita
Physica C: Superconductivity and its Applications   412-414 1261-1266   2004年10月
The mechanical properties and the thermal residual stress distribution of copper in Nb3Sn/Cu composite superconductor were investigated in detail. The stabilizer copper was removed from the composite wire, and the stress-strain behavior of this wi...
Nobuhiro Yoshikawa, Taiji Adachi, Marie Ohshima, Katsuyuki Suzuki, Takami Yamaguchi
Nippon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A   70 1157-1162   2004年9月
Taiji Adachi, Hiromichi Kunimoto, Yoshihiro Tomita
Nippon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A   70 426-433   2004年3月
Using a voxel finite element method that allows us to integrate modeling and analysis of a complicated three-dimensional structure, a new numerical method for shape optimization problem was proposed here based on the traction method. A minimizatio...
Taiji Adachi, Fumiaki Kajita, Katsuya Sato, Koshi Matsumoto, Masahito Tagawa
Nippon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A   69 1782-1788   2003年12月
This study aimed to develop a new cell micro-patterning method by controlling material surface affinity of the cell using atomic oxygen beam exposure. Surfaces of low-density polyethylene (LDPE) and tetrafluoroethylene-hexafluoropropylene (FEP) we...
Ken Ichi Tsubota, Taiji Adachi, Yoshihiro Tomita
Annals of Biomedical Engineering   31 733-740   2003年7月
The effects of a fixation screw on three-dimensional trabecular structural change in a vertebral body were investigated using voxel-based finite element models of trabecular surface remodeling. First, a remodeling simulation was conducted for a ve...
K. Tsubota, T. Adachi
Computational Fluid and Solid Mechanics 2003   1833-1835   2003年6月
© 2003 Elsevier Science Ltd. All rights reserved. Change of compliance tensor of a cancellous bone cube because of remodeling was obtained using a digital image-based model to investigate change in mechanical property of cancellous bone for in viv...
Yoshio Kouta, Taiji Adachi, Yoshihiro Tomita
Zairyo/Journal of the Society of Materials Science, Japan   52 379-385   2003年1月
Polymeric materials under large deformation exhibit localized instability propagation, such as neck propagation under tension and shear band propagation under shearing. In this study, formation and growth of micro-shear bands in a glassy polymeric...
T. Adachi, K. Sato, Y. Tomita
Biomechanics and modeling in mechanobiology   2 73-82   2003年1月
In adaptive bone remodeling, mechanical signals such as stress/strain caused by loading/deformation are believed to play important roles as regulators of the process in which osteoclastic resorption and osteoblastic formation are coordinated under...
K. I. Tsubota, Taiji Adachi, Yoshihiro Tomita
Journal of Biomechanics   35 1541-1551   2002年12月
Two-dimensional simulation of trabecular surface remodeling was conducted for a human proximal femur to investigate the structural change of cancellous bone toward a uniform stress state. Considering that a local mechanical stimulus plays an impor...
Taiji Adachi, Takayuki Murai, Sodai Hoshiai, Yoshihiro Tomita, Hiroshi Wada
JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing   44 914-919   2001年12月
Under the influence of mechanical environment, bone structure is formed and maintained by adaptive remodeling that involves osteoclastic resorption and osteoblastic formation. In the mechanotransduction system in osteoblasts, it is believed that i...
Taiji Adachi, Yuji Kawano, Yoshihiro Tomita
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED   50 545-546   2001年12月
A computational simulation method to predict the change in stiffness of a bone-scaffold system in bone tissue regeneration process was proposed. To evaluate the system from the viewpoint of mechanical function, objective functions using strain ene...
Ken Ichi Tsubota, Taiji Adachi, Yoshihiro Tomita
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED   50 299-300   2001年12月
The relationships between local bone adaptation process at trabecular level and functional adaptation phenomenon at cancellous level were investigated. Two-dimensional simulation of trabecular surface remodeling was performed for a human proximal ...
Katsuya Sato, Taiji Adachi, Yoshihiro Tomita
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED   50 153-154   2001年12月
The directional dependency of the cellular response in a single osteoblastic cell to the mechanical stimuli was investigated. Change in the intracellular calcium ion [Ca2+]i was observed by measuring the increase in fluorescent intensity by using ...
T. Adachi, K. I. Tsubota, Y. Tomita, J. H. Scott
Journal of Biomechanical Engineering   123 403-409   2001年10月
A computational simulation method for three-dimensional trabecular surface remodeling was proposed, using voxel finite element models of cancellous bone, and was applied to the experimental data. In the simulation, the trabecular microstructure wa...
Shigeo Wada, Yasuyuki Seguchi, Masao Tanaka, Mitsumasa Matsuda, Taiji Adachi, Motoharu Fujigaki
JSME International Journal, Series 1: Solid Mechanics, Strength of Materials   35 170-178   1992年4月
Gas flow in the airway and lung deformation due to tissue elasticity and surface tension are the main characteristics of respiratory dynamics. In this study, a simulation with the discretized model as a distributed parameter system is used extensi...
Taiji Adachi, Takayuki Murai, Sodai Hoshiai, Yoshihiro Tomita
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A   67 349-354   2001年1月
Under the influence of mechanical environment, bone structure is formed and maintained by adaptive remodeling which involves osteoclastic resorption and osteoblastic formation. In the mechanotransduction system in osteoblasts, it is believed that ...
Taiji Adachi, Ken Ichi Tsubota, Yoshihiro Tomita
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A   66 1640-1647   2000年1月
Recent advances in understanding of mechanical bone remodeling have been progressed by computational mechanics approach that allows analysis of structural and functional changes of bone with hierarchical structure under complicated mechanical envi...
Taiji Adachi, Ken Ichi Tsubota, Yoshihiro Tomita, Scott J. Hollister
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED   42 699-700   1999年12月
The basic features of the trabecular remodeling were investigated based on a uniform stress analysis. In addition, the applicability to predict the remodeling around the rod screw interface was demonstrated. Trabecular changed their morphology to ...
Taiji Adachi, Yoshihiro Tomita, Masao Tanaka
JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing   42 470-480   1999年1月
In this article, we discuss a mechanical model for structural and remodeling analysis/simulation of cancellous bone, that takes into account tissue microstructure and residual stress. A three-dimensional lattice continuum is used as a structural m...
Taiji Adachi, Yoshihiro Tomita, Masao Tanaka
International Journal of Mechanical Sciences   40 857-866   1998年9月
Finite element methods for an elastic Cosserat continuum obeying micropolar theory and couple stress theory are developed and applied to the simulation of stress concentration around a circular hole in a lattice continuum plate, in which the latti...
Taiji Adachi, Yoshihiro Tomita, Yosuke Kashu
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A   64 758-764   1998年1月
Neck propagation of polymeric materials under tension is a characteristic feature which can be physically explained by the deformation-induced evolution of molecular chain structure. In this study, atomic force microscope is applied to glassy poly...
T. Adachi, M. Tanaka, Y. Tomita
Journal of Biomechanical Engineering   120 342-347   1998年1月
Residual stress and strain in living tissues have been investigated from the viewpoint of mechanical optimality maintained by adaptive remodeling. In this study, the residual stresses in the cortical-cancellous bone complex of bovine coccygeal ver...
Y. Tomita, T. Adachi, S. Tanaka
Archives of Computational Methods in Engineering   5 167-198   1998年1月
The purpose of the present article is to provide a perspective for computational predictions related to plastic instabilities such as bulge, neck and shear band formation and their propagation in polymeric materials under a variety of deformation ...
Shigeyuki Tanaka, Yoshihiro Tomita, Taiji Adachi
Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A   64 1916-1922   1998年1月
A nonaffine molecular chain network model of glassy polymers in which the number of entangled points of molecular chains may change according to the local distortion caused by the deformation and the temperature increase has been developed. A simp...
Taiji Adachi, Yoshihiro Tomita, Masao Tanaka
American Society of Mechanical Engineers, Bioengineering Division (Publication) BED   35 95-96   1997年12月
Yoshihiro Tomita, Taiji Adachi
Materials Science Research International   3 125-136   1997年9月
The purpose of the present article is to provide a perspective for a network model for glassy polymers and computational predictions of mechanical behavior related to plastic instabilities, such as neck and shear band formation, and their propagat...
Yoshihiro Tomita, Taiji Adachi, Park Sung Sik
International Journal of Mechanical Sciences   39 913-923   1997年8月
The three-dimensional neck propagation behavior of a glassy polymer under tension, which obeys a constitutive equation based on the molecular chain network theory, was investigated numerically. An experimental observation of tension in polycarbona...
Y. Tomita, T. Adachi, S. Tanaka
European Journal of Mechanics, A/Solids   16 745-755   1997年1月
In order to develop a constitutive equation for glassy polymers in a general deformation state, a nonaffine model for a molecular chain network structure which evolves with the local deformation has been proposed. A simple equation which directly ...
Taiji Adachi, Yoshihiro Tomita, Hiroshi Sakaue, Masao Tanaka
Nippon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C   63 777-784   1997年1月
To investigate mechanical remodeling of cancellous bone from the viewpoint of trabecular surface remodeling due to trabecular level mechanical stimuli, first, a rate equation for trabecular surface remodeling is proposed based on the uniform stres...
Yoji Shibutani, Akinori Taniyama, Yoshihiro Tomita, Taiji Adachi
Zairyo/Journal of the Society of Materials Science, Japan   46 893-899   1997年1月
By the duplex effect produced by two kinds of phases of austenite and martensite, the transformation-induced plasticity (TRIP) steel is improved in ductility and fracture toughness. The strain-induced martensitic phase transformation could be asso...
Taiji Adachi, Yoshihiro Tomita, Hiroshi Sakaue, Masao Tanaka
JSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing   40 782-792   1997年1月
In this study, to investigate mechanical remodeling of cancellous bone from the viewpoint of trabecular surface remodeling due to trabecular level mechanical stimuli, a rate equation for trabecular surface remodeling is proposed based on the unifo...
Masao Tanaka, Taiji Adachi, Yoshihiro Tomita
JSME International Journal, Series A: Mechanics and Material Engineering   39 297-305   1996年7月
Mechanical remodeling of bone is a kind of adaptation and is performed to regulate the stress and/or strain in the tissue in response to the changing mechanical environment due to tissue growth and atrophy. We propose a phenomenological model of m...
椎体骨梁構造の特徴量計測 : 骨梁密度と配向性の分布
安達泰治, 冨田佳宏, 松井修, 田中正夫\t
日本臨床バイオメカニクス学会誌 = Proceedings of ... Annual Meeting of Japanese Society for Clinical Biomechanics and Related Research   16 173-176   1995年10月   [査読有り]
圧縮負荷を受ける海綿骨組織の微視的骨梁破壊挙動のSEM観察
安達泰治, 冨田佳宏
日本臨床バイオメカニクス学会誌 = Proceedings of ... Annual Meeting of Japanese Society for Clinical Biomechanics and Related Research   17 325-329   1996年10月   [査読有り]
固定用スクリュー近傍の三次元骨梁リモデリングシミュレーション
坪田健一,澁谷 基,安達泰治,冨田佳宏
日本臨床バイオメカニクス学会誌 = Proceedings of ... Annual Meeting of Japanese Society for Clinical Biomechanics and Related Research   22 35-39   2001年10月   [査読有り]
骨-ステム界面の応力一様化に基づく人工股関節ステムの形状決定シミュレーション
安達泰治,冨田佳宏,國本宏通,坪田健一
日本臨床バイオメカニクス学会誌 = Proceedings of ... Annual Meeting of Japanese Society for Clinical Biomechanics and Related Research   23 405-410   2002年11月   [査読有り]
一軸延伸したHAp/高分子量PLLA 複合材料 の変形・破壊特性評価
田中秀和,北條正樹,玄丞烋,田中基嗣,安達泰治,近田英一
第32 回複合材料シンポジウム(2007.10.18-19.長崎)      2007年   [査読有り]
押出により微視構造の配向した HAp/PLLA 複合材料の変形・破壊特性
山本展之,田中秀和,田中基嗣,北條正樹,安達泰治,玄丞烋,近田英一
第53回FRP CON-EX 講演会(2008.11.25-26.京都)      2008年   [査読有り]
細胞運動におけるアクチン細胞骨格構造システムのバイオメカニクス
安達泰治
九州大学グローバルCOE プログラム「未来分子システム科学」第130 回セミナー(2010.11.25 福岡)      2010年   [査読有り]
Beagle のμCT データの3 次元有限要素解析を用いた矯正的歯の移動シミュレーション
長谷川正和,清流正弘,安達泰治,山本照子
第69 回日本矯正歯科学会大会(2010.9.27-29 横浜)      2010年   [査読有り]
足関節周囲の骨支持性を考慮した人工足関節の検討
伊藤宣,野山義裕,安達泰治,中村孝志
第37 回日本臨 床バイオメカニクス学会(2010.11.1-3 京都)      2010年   [査読有り]
分子動力学法を用いたアクチンフィラメントの引張・ね じり剛性評価
松下慎二,安達泰治,井上康博,北條正樹,曽我部正博
日本機械学会.日本機械学会2010 年度年次大会(2010.9.5-9 名古屋)      2010年   [査読有り]
再構築による骨梁形態変化を考慮した骨梁骨の力学的特性評価
田原大輔,安達泰治
第37 回日本臨床バイオメ Annual Report 2010 附属ナノ再生医工学研究センター-156- カニクス学会(2010.11.1-3 京都)      2010年   [査読有り]
骨の「かたち」は力に応じて変化する
安達泰治
京都大学再生医科学研究所第5 回公開講演会,「身体と再生- 細胞から細胞社会へ-」(2010.7.24 京都)      2010年   [査読有り]
骨のリモデリングによる機能的適応のバイオメカニクス
安達泰治
第 86 回岡山県医用工学研究会(. 2010.10.20 岡山)(特別講演)      2010年   [査読有り]
骨の機能的適応のシステムバイオメカニクス
安達泰治
第 23 回京滋骨粗鬆症研究会(. 2010.10.23 京都)(特別講演)      2010年   [査読有り]

書籍等出版物

 
応力解析を用いた設計-人工足関節を例に
安達泰治,伊藤 宣
未来型人工関節を目指して‐その歴史から将来展望まで‐, 編:吉川秀樹, 中野貴由, 松岡厚子, 中島義雄, pp. 87-90, 日本医学館.   
有限要素法による海綿骨の力学的評価:骨梁構造の力学解析とリモデリングシミュレーション
安達泰治, 他(分担執筆)
骨粗鬆症の椎体骨折-骨の量, 構造と強度, pp. 110-117, メディカルカルチュア社,東京.   2002年9月   
生体組織・細胞のリモデリングのバイオメカニクス(ME教科書シリーズB-6)
林紘三郎,安達泰治,宮崎 浩(共著),日本エム・イー学会編
コロナ社, (ISBN: 4-339-07146-3),東京.   2003年3月   
構造工学ハンドブック
安達泰治(分担執筆)
13.2.1(1) 生体組織構造-骨構造, pp. 803-805, 13.3.2(2) 解析手法-適応力学解析, pp. 835-837,矢川元基(編),丸善.   2004年3月   
機械工学便覧デザイン編β8
安達泰治(分担執筆)
第2.1.2項「実験力学的方法」, pp. 23-29.日本機械学会編.   2007年1月   

講演・口頭発表等

 
Hiromi Miyoshi, Kensuke Suzuki, Jungmyoung Ju, Jong Soo Ko, Taiji Adachi, Yutaka Yamagata
Analytical Sciences   2016年1月1日   
© Japan Society for Analytical Chemistry. Migrating cells in vivo monitor the physiological state of an organism by integrating the physical as well as chemical cues in the extracellular microenvironment, and alter the migration mode, in order to ...
D. Tawara, K. Nagura, T. Tsujikami, T. Adachi
IFMBE Proceedings   2014年1月1日   
© Springer International Publishing Switzerland 2014. Mechanical bone quality and its related loadsupporting function at the macro-scale is a result of adaptation, which is achieved by trabecular bone remodeling at the microscale. The increase in ...
Takafumi Ogawa, Takao Shimayoshi, Naoki Kida, Taiji Adachi, Tetsuya Matsuda
Transactions of Japanese Society for Medical and Biological Engineering   2014年1月1日   
© 2014, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. In standard finite element analysis in structural dynamics, meshing can affect computation results. However, there have been no detailed report about effects of mes...
Simona Patriche, Simona Patriche, Shinji Matsushita, Shinji Matsushita, Mihaela Banu, Mihaela Banu, Bogdan I. Epureanu, Taiji Adachi, Taiji Adachi
Proceedings of SPIE - The International Society for Optical Engineering   2011年5月23日   
This work is concerned with the dynamics of motor proteins. In particular, we discuss the development of computational analysis tools for predicting the dynamics of molecular motors such as certain types of kinesin. The ability to model and predic...

競争的資金等の研究課題

 
生体組織の機能的適応に関するバイオメカニクス
骨芽細胞の力学的刺激に対する応答

特許

 
骨組織再生のための代替物構造設計支援方法とその装置
特開:2002-65708
細胞接着材料
特願:2003-274530