2010年
Trabecular bone remodelling simulation considering osteocytic response to fluid-induced shear stress
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
- ,
- ,
- 巻
- 368
- 号
- 1920
- 開始ページ
- 2669
- 終了ページ
- 2682
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1098/rsta.2010.0073
- 出版者・発行元
- ROYAL SOC
In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system are believed to play important roles in the mechanosensory system. Under dynamic loading, bone matrix deformation generates an interstitial fluid flow in the lacuno-canalicular system; this flow induces shear stress on the osteocytic process membrane that is known to stimulate the osteocytes. In this sense, the osteocytes behave as mechanosensors and deliver mechanical information to neighbouring cells through the intercellular communication network. In this study, bone remodelling is assumed to be regulated by the mechanical signals collected by the osteocytes. From the viewpoint of multi-scale biomechanics, we propose a mathematical model of trabecular bone remodelling that takes into account the osteocytic mechanosensory network system. Based on this model, a computational simulation of trabecular bone remodelling was conducted for a single trabecula under cyclic uniaxial loading, demonstrating functional adaptation to the applied mechanical loading as a load-bearing construct.
- リンク情報
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- DOI
- https://doi.org/10.1098/rsta.2010.0073
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20439268
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000277207300006&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-77953527913&partnerID=MN8TOARS
- ID情報
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- DOI : 10.1098/rsta.2010.0073
- ISSN : 1364-503X
- eISSN : 1471-2962
- ORCIDのPut Code : 38323972
- PubMed ID : 20439268
- SCOPUS ID : 77953527913
- Web of Science ID : WOS:000277207300006