論文

査読有り
2019年12月

Forceful mastication activates osteocytes and builds a stout jawbone

Scientific Reports
  • Masamu Inoue
  • ,
  • Takehito Ono
  • ,
  • Yoshitaka Kameo
  • ,
  • Fumiyuki Sasaki
  • ,
  • Takashi Ono
  • ,
  • Taiji Adachi
  • ,
  • Tomoki Nakashima

9
1
開始ページ
4404
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/s41598-019-40463-3
出版者・発行元
Springer Science and Business Media {LLC}

Bone undergoes a constant reconstruction process of resorption and formation called bone remodeling, so that it can endure mechanical loading. During food ingestion, masticatory muscles generate the required masticatory force. The magnitude of applied masticatory force has long been believed to be closely correlated with the shape of the jawbone. However, both the mechanism underlying this correlation and evidence of causation remain largely to be determined. Here, we established a novel mouse model of increased mastication in which mice were fed with a hard diet (HD) to elicit greater masticatory force. A novel in silico computer simulation indicated that the masticatory load onto the jawbone leads to the typical bone profile seen in the individuals with strong masticatory force, which was confirmed by in vivo micro-computed tomography (micro-CT) analyses. Mechanistically, increased mastication induced Insulin-like growth factor (IGF)-1 and suppressed sclerostin in osteocytes. IGF-1 enhanced osteoblastogenesis of the cells derived from tendon. Together, these findings indicate that the osteocytes balance the cytokine expression upon the mechanical loading of increased mastication, in order to enhance bone formation. This bone formation leads to morphological change in the jawbone, so that the bone adapts to the mechanical environment to which it is exposed.

リンク情報
DOI
https://doi.org/10.1038/s41598-019-40463-3
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000461760000001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1038/s41598-019-40463-3
  • ISSN : 2045-2322
  • ORCIDのPut Code : 62290941
  • Web of Science ID : WOS:000461760000001

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