論文

査読有り
2010年

Effectiveness of scaffolds with pre-seeded mesenchymal stem cells in bone regeneration - Assessment of osteogenic ability of scaffolds implanted under the periosteum of the cranial bone of rats-

Dental Materials Journal
  • Baba, S.
  • ,
  • Inoue, T.
  • ,
  • Hashimoto, Y.
  • ,
  • Kimura, D.
  • ,
  • Ueda, M.
  • ,
  • Sakai, K.
  • ,
  • Matsumoto, N.
  • ,
  • Hiwa, C.
  • ,
  • Adachi, T.
  • ,
  • Hojo, M.

29
6
開始ページ
673
終了ページ
681
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.4012/dmj.2009-123
出版者・発行元
JAPANESE SOC DENTAL MATERIALS DEVICES

To date, there has been no study on the development of novel regimens based on the following tissue engineering principles: seeding and culturing mesenchymal stem cells (MSCs) on a scaffold before surgery or injecting cultured MSCs into a scaffold during surgery. The purpose of this study was to assess the in vivo osteogenic ability of scaffold/MSCs implanted beneath the periosteum of the cranial bone of rats in three different sample groups: one in which MSCs were pre-seeded and cultured on a scaffold to produce the 3-D woven fabric scaffold/MSC composite using osteo-lineage induction medium, one in which cultured MSCs produced by osteo-lineage induction in cell cultivation flasks were injected into a scaffold during surgery and a control group, in which only the 3-D woven fabric scaffold was implanted. The results indicate that pre-seeding MSCs on a scaffold leads to a higher osteogenic ability than injecting cultured MSCs into a scaffold during surgery.

リンク情報
DOI
https://doi.org/10.4012/dmj.2009-123
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000287172000007&DestApp=WOS_CPL
URL
http://www.scopus.com/inward/record.url?eid=2-s2.0-78650057292&partnerID=MN8TOARS
ID情報
  • DOI : 10.4012/dmj.2009-123
  • ISSN : 0287-4547
  • ORCIDのPut Code : 38323992
  • SCOPUS ID : 78650057292
  • Web of Science ID : WOS:000287172000007

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