2010年
Effectiveness of scaffolds with pre-seeded mesenchymal stem cells in bone regeneration - Assessment of osteogenic ability of scaffolds implanted under the periosteum of the cranial bone of rats-
Dental Materials Journal
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- 巻
- 29
- 号
- 6
- 開始ページ
- 673
- 終了ページ
- 681
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.4012/dmj.2009-123
- 出版者・発行元
- JAPANESE SOC DENTAL MATERIALS DEVICES
To date, there has been no study on the development of novel regimens based on the following tissue engineering principles: seeding and culturing mesenchymal stem cells (MSCs) on a scaffold before surgery or injecting cultured MSCs into a scaffold during surgery. The purpose of this study was to assess the in vivo osteogenic ability of scaffold/MSCs implanted beneath the periosteum of the cranial bone of rats in three different sample groups: one in which MSCs were pre-seeded and cultured on a scaffold to produce the 3-D woven fabric scaffold/MSC composite using osteo-lineage induction medium, one in which cultured MSCs produced by osteo-lineage induction in cell cultivation flasks were injected into a scaffold during surgery and a control group, in which only the 3-D woven fabric scaffold was implanted. The results indicate that pre-seeding MSCs on a scaffold leads to a higher osteogenic ability than injecting cultured MSCs into a scaffold during surgery.
- リンク情報
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- DOI
- https://doi.org/10.4012/dmj.2009-123
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000287172000007&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-78650057292&partnerID=MN8TOARS
- ID情報
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- DOI : 10.4012/dmj.2009-123
- ISSN : 0287-4547
- ORCIDのPut Code : 38323992
- SCOPUS ID : 78650057292
- Web of Science ID : WOS:000287172000007