2019年8月
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function.
Nature reviews. Neuroscience
- ,
- ,
- 巻
- 20
- 号
- 8
- 開始ページ
- 451
- 終了ページ
- 465
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41583-019-0196-3
Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan (CSPG)-containing structures that surround the soma and dendrites of various mammalian neuronal cell types. PNNs appear during development around the time that the critical periods for developmental plasticity end and are important for both their onset and closure. A similar structure - the perinodal ECM - surrounds the axonal nodes of Ranvier and appears as myelination is completed, acting as an ion-diffusion barrier that affects axonal conduction speed. Recent work has revealed the importance of PNNs in controlling plasticity in the CNS. Digestion, blocking or removal of PNNs influences functional recovery after a variety of CNS lesions. PNNs have further been shown to be involved in the regulation of memory and have been implicated in a number of psychiatric disorders.
- リンク情報
- ID情報
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- DOI : 10.1038/s41583-019-0196-3
- PubMed ID : 31263252