MISC

国際誌
2007年4月

The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis.

Journal of lipid research
  • Masako Tabuchi
  • Katsumi Inoue
  • Hitomi Usui-Kataoka
  • Kazuko Kobayashi
  • Misako Teramoto
  • Koji Takasugi
  • Kenichi Shikata
  • Masahiro Yamamura
  • Kenji Ando
  • Keiichiro Nishida
  • Junko Kasahara
  • Noriaki Kume
  • Luis R Lopez
  • Kazuaki Mitsudo
  • Masakiyo Nobuyoshi
  • Tatsuji Yasuda
  • Toru Kita
  • Hirofumi Makino
  • Eiji Matsuura
  • 全て表示

48
4
開始ページ
768
終了ページ
81
記述言語
英語
掲載種別
DOI
10.1194/jlr.M600414-JLR200
出版者・発行元
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

C-reactive protein (CRP) is one of the strongest independent predictors of cardiovascular disease. We have previously reported that oxidized LDL (oxLDL) interacts with beta 2-glycoprotein I (beta 2GPI), implicating oxLDL/P2GPI complexes as putative autoantigens in autoimmune-mediated atherosclerotic vascular disease. In this study, we investigated the interaction of CRP with oxLDL/beta 2GPI complexes and its association with atherosclerosis in patients with diabetes mellitus (DM). CRP/oxLDL/R2GPI complexes were predominantly found in sera of DM patients with atherosclerosis. In contrast, noncomplexed CRP isoforms were present in sera of patients with acute/chronic inflammation, i.e., various pyrogenic diseases, rheumatoid arthritis (RA), and DM. Immunohistochemistry staining colocalized CRP and beta 2GPI together with oxLDL in carotid artery plaques but not in synovial tissue from RA patients, strongly suggesting that complex formation occurs during the development of adierosclerosis. Serum levels of CRP correlated with soluble forms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, and oxLDL/beta 2GPI complexes correlated with total cholesterol and hemoglobin Al c. Thus, the generation of CRP/oxLDL/beta 2GPI complexes seems to be associated with arterial inflammation, hyperglycemia, and hypercholesterolemia. CRP/oxLDL/R2GPI complexes can be distinguished from pyrogenic noncomplexed CRP isoforms and may represent a more specific and predictive marker for atherosclerosis.

リンク情報
DOI
https://doi.org/10.1194/jlr.M600414-JLR200
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17261875
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000245627100003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1194/jlr.M600414-JLR200
  • ISSN : 0022-2275
  • PubMed ID : 17261875
  • Web of Science ID : WOS:000245627100003

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