1999年5月
Platelet-derived endothelial cell growth factor is not implicated in progression of cervical cancer
ONCOLOGY REPORTS
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- 巻
- 6
- 号
- 3
- 開始ページ
- 617
- 終了ページ
- 620
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- PROFESSOR D A SPANDIDOS
We examined the expression of platelet-derived endothelial cell growth factor (PD-ECGF) mRNAs in 47 invasive cervical cancer tissues by semi-quantitative RT-PCR and addressed its association with clinicopathological features including microvessel density. Squamous cell carcinomas expressed higher levels of PD-ECGF mRNA than non-squamous cell carcinomas (P=0.014). We found no association between FIGO stage and levels of PD-ECGF mRNA. A subset of 31 patients with stage Ib-II cervical cancer underwent radical hysterectomy and pelvic lymphadenectomy. There were no significant differences in PD-ECGF mRNA levels with respect to tumor size, degree of stromal invasion, lymph-vascular space involvement, parametrial involvement, vaginal involvement or lymph node metastasis among these patients. There was no correlation between microvessel density and the levels of PD-ECGF mRNA. These findings suggest that PD-ECGF expression is not associated with progression and metastasis of cervical cancer.
- リンク情報
- ID情報
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- ISSN : 1021-335X
- Web of Science ID : WOS:000079756500025