Ken Tsutsui

Profile Information

Affiliation: Professor, Advanced Science Research Center, Advanced Science Research Center,Okayama University, Okayama University

Degree: M.D.(Okayama University)
Ph.D.

J-GLOBAL ID: 200901098656328205
researchmap Member ID: 1000035076

External link: http://nbgp.med.okayama-u.ac.jp/

Research Interests

Research Areas

Education

- 1976

Okayama University
- 1976

Graduate School, Division of Medicine, Okayama University
- 1972

Faculty of Medicine, Medical School, Okayama University
- 1972

Faculty of Medicine, Okayama University

Committee Memberships

2003

評議員, 日本生化学会

Misc.

231

Nuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domain

Kimiko M. Tsutsui, Kuniaki Sano, Osamu Hosoya, Tadashi Miyamoto, Ken Tsutsui

NUCLEIC ACIDS RESEARCH, 39(12) 5067-5081, Jul, 2011
Detection and isolation of nanobacteria-like particles from urinary stones: Long-withheld data

Hiromi Kumon, Akira Matsumoto, Shinya Uehara, Fernando Abarzua, Motoo Araki, Ken Tsutsui, Ken-ichi Tomochika

INTERNATIONAL JOURNAL OF UROLOGY, 18(6) 458-465, Jun, 2011
A new risk assessment method for evaluation of oxidative chemicals using catalase mutant mouse primary hepatocytes

Da-Hong Wang, Yasuo Ishikawa, Masahiro Miyazaki, Hirofumi Fujita, Ken Tsutsui, Kuniaki Sano, Noriyoshi Masuoka, Keiki Ogino

Health, 3(5) 288-291, 2011
The Matrix Protein hnRNP U Is Required for Chromosomal Localization of Xist RNA

Yuko Hasegawa, Neil Brockdorff, Shinji Kawano, Kimiko Tsutui, Ken Tsutui, Shinichi Nakagawa

DEVELOPMENTAL CELL, 19(3) 469-476, Sep, 2010
Regulation of DNA Topoisomerase II beta through RNA-dependent Association with Heterogeneous Nuclear Ribonucleoprotein U (hnRNP U)

Shinji Kawano, Mary Miyaji, Shoko Ichiyasu, Kimiko M. Tsutsui, Ken Tsutsui

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(34) 26451-26460, Aug, 2010
Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

Kyoko Nakamura, Toshiaki Kogame, Hiroyuki Oshiumi, Akira Shinohara, Yoshiki Sumitomo, Keli Agama, Yves Pommier, Kimiko M. Tsutsui, Ken Tsutsui, Edgar Hartsuiker …

PLOS GENETICS, 6(1) 1-12, Jan, 2010
DNAトポイソメラーゼIIβによる神経関連遺伝子の活性化機構

佐野訓明, 宮地まり, 筒井公子, 筒井研

岡山医学会雑誌, 121(3) 143-147, 2009
DNAトポイソメラーゼIIβによる神経関連遺伝子の発現制御

筒井研, 筒井公子, 宮地まり, 佐野訓明

蛋白質核酸酵素, 54(11) 1333-1343, 2009
Topoisomerase II beta Activates a Subset of Neuronal Genes that Are Repressed in AT-Rich Genomic Environment

Kuniaki Sano, Mary Miyaji-Yamaguchi, Kimiko M. Tsutsui, Ken Tsutsui

PLOS ONE, 3(12) 1-13, Dec, 2008
Development of a new assay for evaluation of L-3,4-dihydroxyphenylalanine cytotoxicity in catalase-mutant Escherichia coli

Da-Hong Wang, Masako Horita, Ken Tsutsu, Kuniaki Sano, Rani Sauriasari, Noriyoshi Masuoka, Yoko Takemura, Tomoko Takigawa, Jiro Takaki, Keiki Ogino

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 27(8) 1768-1772, Aug, 2008
Cytotoxicity of lawsone and cytoprotective activity of antioxidants in catalase mutant Escherichia coli

Rani Sauriasari, Da-Hong Wang, Yoko Takemura, Ken Tsutsui, Noriyoshi Masuoka, Kuniaki Sano, Masako Horita, Bng-Ling Wang, Keiki Ogino

TOXICOLOGY, 235(1-2) 103-111, Jun, 2007
Correlations between scaffold/matrix attachment region (S/MAR) binding activity and DNA duplex destabilization energy

J Bode, S Winkelmann, S Gotze, S Spiker, K Tsutsuil, CP Bi, AK Prashanth, C Benham

JOURNAL OF MOLECULAR BIOLOGY, 358(2) 597-613, Apr, 2006
Stilbenoids of Kobresia nepalensis (Cyperaceae) exhibiting DNA topoisomerase II inhibition

M Yamada, K Hayashi, H Hayashi, S Ikeda, T Hoshino, K Tsutsui, K Tsutsui, M Iinuma, H Nozaki

PHYTOCHEMISTRY, 67(3) 307-313, Feb, 2006
核マトリックスとRNAを結ぶもの

筒井研, 河野真二

蛋白質核酸酵素, 51,14,1964-1969, 2006
Expression dynamics and functional implications of DNA topoisomerase Ⅱβ in the brain

Tsutsui K M, Sano K, Hosoya O, Tsusui K

Anatomical Science International, 81,156-163, 2006
Inhibitory activity of plant stilbene oligomeres against DNA topoisomerase Ⅱ

Yamada M, Hayashi K, Ikeda S, Tsutsui K, Tsutsui K M, Ito T, Iinuma M, Nozaki H

Biol.Pharm.Bull., 29(7) 1504-1507, 2006
Nepalensinols D-G,new resveratrol oligomers from Kobresia nepalensis (Cyperaceae) as potent inhibitors of DNA topoisomerase Ⅱ

Yamada M, Hayashi K, Hayashi H, Tsuji R, Kakumoto K, Ikeda S, Hoshino T, Tsutsui K, Tsutsui K M, Ito T …

Chem Pham Bull, 54(3) 354-358, 2006
Involvement of oxidative stress in hydroquinone-induced cytotoxicity in catalase-deficient Escherichia coli mutants

M Horita, DH Wang, K Tsutsui, K Sano, N Masuoka, S Kira

FREE RADICAL RESEARCH, 39(10) 1035-1041, Oct, 2005
Dynamic view of the nuclear matrix.

Tsutsui K M, Sano K, Tsutsui K

Acta Med.Okayama, 59,113-120, 2005
Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7

N Purbowasito, C Suda, T Yokomine, M Zubair, T Sado, K Tsutsui, H Sasaki

DNA RESEARCH, 11(6) 391-407, Dec, 2004

Books and Other Publications

分子細胞生物学辞典

東京化学同人, 2007
細胞核のダイナミクス

シュプリンガー・フェアラーク東京,東京, 2004
Differential expression of DNA topoisomerase II isozymes in developing rat brain（共著）

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy
(Differential expression of DNA topoisomerase II isozymes in developing rat brain)(jointly worked)

(Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy)
(Differential expression of DNA topoisomerase II isozymes in developing rat brain)(jointly worked)

(Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy)

Presentations

102

遠隔ゲノム部位間の相互作用におけるII型DNAトポイソメラーゼの役割

文部科学省科学研究費新学術領域研究「生命科学系3分野支援活動」“ゲノム支援”2011年度拡大班会議, 2011
網膜視細胞の終末分化におけるDNAトポイソメラーゼIIβの役割

第34回日本分子生物学会年会, 2011
人工合成ペプチドの超らせんＤＮＡへの選択的結合

第34回日本分子生物学会年会, 2011
DNAトポイソメラーゼⅡβのRNAによる活性調節と核内局在変化

第34回日本分子生物学会年会, 2011
DNAトポイソメラーゼIIβによる遠隔ゲノム部位間の相互作用

第34回日本分子生物学会年会, 2011
核マトリックスタンパク質SP120/SAF-A/hnRNP Uの新たなMAR特異的DNA結合領域の同定

第34回日本分子生物学会年会, 2011
トポイソメラーゼIIβは離れたゲノム部位の間ではたらくか。

第10回細胞核ダイナミクス研究会, 2011
Transcriptional Induction of Neuronal Genes by Targeted Action of DNA Topoisomerase IIb.

Advances in DNA Topoisomerase and Chromosome Dynamics., 2011
人工合成ペプチドによる超らせんDNAの分子認識

第84回日本生化学会大会, 2011
hnRNP UはXist RNA局在制御を通じてX染色体不活性化に関与する

第84回日本生化学会大会, 2011
Regulatory roles of DNA topoisomerase IIβ in the developing cerebellar neurons.

Fourth International Congress of the Society for Research on the Cerebellum., 2011
低カタラーゼ活性マウスの初代培養肝細胞を用いた環境有害物質評価法の開発（第2 報）

第81回日本衛生学会学術総会, 2011
II型DNAトポイソメラーゼによる神経関連遺伝子の発現制御

新潟脳神経研究会, 2011
From topology to topography: Regulation of Neuronal genes by targeted action of DNA topoisomerase IIβ.

International Symposium ‘Physicochemical Field for genetic activities’, 2011
カタラーゼ活性の異なるマウスの初代培養肝細胞に及ぼすヒドロキノンの影響

第8回日本予防医学会学術総会, 2010
酸化型・還元型グルタチオンによるII型DNAトポイソメラーゼ活性の制御

第33回日本分子生物学会年会第83回日本生化学会大会合同大会, 2010
DNAトポイソメラーゼIIβの核内における移動メカニズム

第33回日本分子生物学会年会第83回日本生化学会大会合同大会, 2010
網膜杵体視細胞の終末分化におけるDNAトポイソメラーゼIIβの関与

第33回日本分子生物学会年会第83回日本生化学会大会合同大会, 2010
DNAトポイソメラーゼIIβの遠位通過部位マッピング法（eTIP-HiC）の開発

第33回日本分子生物学会年会第83回日本生化学会大会合同大会, 2010
DNAトポイソメラーゼIIβの神経関連遺伝子へのターゲット機構

第33回日本分子生物学会年会第83回日本生化学会大会合同大会, 2010

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