Papers

International journal
May, 2018

Oncological impact of neoadjuvant hormonal therapy on permanent iodine-125 seed brachytherapy in patients with low- and intermediate-risk prostate cancer.

International journal of urology : official journal of the Japanese Urological Association
  • Atsushi Takamoto
  • ,
  • Ryuta Tanimoto
  • ,
  • Kensuke Bekku
  • ,
  • Motoo Araki
  • ,
  • Takuya Sadahira
  • ,
  • Koichiro Wada
  • ,
  • Shin Ebara
  • ,
  • Norihisa Katayama
  • ,
  • Hiroyuki Yanai
  • ,
  • Yasutomo Nasu

Volume
25
Number
5
First page
507
Last page
512
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1111/iju.13555

OBJECTIVES: To determine whether neoadjuvant hormonal therapy improves oncological outcomes of patients with localized prostate cancer treated with permanent brachytherapy. METHODS: Between January 2004 and November 2014, 564 patients underwent transperineal ultrasonography-guided permanent iodine-125 seed brachytherapy. We retrospectively analyzed low- or intermediate-risk prostate cancer based on the National Comprehensive Cancer Network guidelines. The clinical variables were evaluated for influence on biochemical recurrence-free survival, progression-free survival, cancer-specific survival and overall survival. RESULTS: A total of 484 patients with low-risk (259 patients) or intermediate-risk disease (225 patients) were evaluated. Of these, 188 received neoadjuvant hormonal therapy. With a median follow up of 71 months, the 5-year actuarial biochemical recurrence-free survival rates of patients who did and did not receive neoadjuvant hormonal therapy were 92.9% and 93.6%, respectively (P = 0.2843). When patients were stratified by risk group, neoadjuvant hormonal therapy did not improve biochemical recurrence-free survival outcomes in low- (P = 0.8949) or intermediate-risk (P = 0.1989) patients. The duration or type of hormonal therapy was not significant in predicting biochemical recurrence. In a multivariate analysis, Gleason score, pretreatment prostate-specific antigen, clinical T stage, and prostate dosimetry, primary Gleason score and positive core rate were significant predictive factors of biochemical recurrence-free survival, whereas neoadjuvant hormonal therapy was insignificant. Furthermore, neoadjuvant hormonal therapy did not significantly influence progression-free survival, cancer-specific survival or overall survival. CONCLUSIONS: In patients with low- or intermediate-risk disease treated with permanent prostate brachytherapy, neoadjuvant hormonal therapy does not improve oncological outcomes. Its use should be restricted to patients who require prostate volume reduction.

Link information
DOI
https://doi.org/10.1111/iju.13555
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29651796
ID information
  • DOI : 10.1111/iju.13555
  • Pubmed ID : 29651796

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