Misc.

Apr, 2016

Adhesion molecules and the extracellular matrix as drug targets for glioma.

Brain tumor pathology
  • Toshihiko Shimizu
  • ,
  • Kazuhiko Kurozumi
  • ,
  • Joji Ishida
  • ,
  • Tomotsugu Ichikawa
  • ,
  • Isao Date

Volume
33
Number
2
First page
97
Last page
106
Language
English
Publishing type
DOI
10.1007/s10014-016-0261-9
Publisher
SPRINGER JAPAN KK

The formation of tumor vasculature and cell invasion along white matter tracts have pivotal roles in the development and progression of glioma. A better understanding of the mechanisms of angiogenesis and invasion in glioma will aid the development of novel therapeutic strategies. The processes of angiogenesis and invasion cause the production of an array of adhesion molecules and extracellular matrix (ECM) components. This review focuses on the role of adhesion molecules and the ECM in malignant glioma. The results of clinical trials using drugs targeted against adhesion molecules and the ECM for glioma are also discussed.

Link information
DOI
https://doi.org/10.1007/s10014-016-0261-9
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26992378
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000373565700004&DestApp=WOS_CPL
ID information
  • DOI : 10.1007/s10014-016-0261-9
  • ISSN : 1433-7398
  • eISSN : 1861-387X
  • Pubmed ID : 26992378
  • Web of Science ID : WOS:000373565700004

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