Tsutomu Inokuchi

Profile Information

Affiliation: Associate Professor, The Graduate School of Natural Science and Technology, Graduate School of Natural Science and Technology,Okayama University, Okayama University

Degree: Doctor of Engineering(Nagoya University)

J-GLOBAL ID: 200901089111685931
researchmap Member ID: 1000035632

External link: http://www.biotech.okayama-u.ac.jp/dept/intro.html

Research Interests

Research Areas

Research History

Education

- 1972

Okayama University
- 1972

Graduate School, Division of Engineering, Okayama University
- 1971

Faculty of Engineering, Okayama University
- 1971

Faculty of Engineering, Okayama University

Committee Memberships

Awards

Misc.

Design, synthesis, and in vitro cancer cell growth inhibition evaluation and antimalarial testing of trioxanes installed in cyclic 2-enoate substructures

Md. Imran Hossain, Marta Switalska, Wei Peng, Mariko Takashima, Ning Wang, Marcel Kaiser, Joanna Wietrzyk, Shingo Dan, Takao Yamori, Tsutomu Inokuchi

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 69 294-309, Nov, 2013
Design, synthesis, and in vitro cancer cell growth inhibition evaluation and antimalarial testing of trioxanes installed in cyclic 2-enoate substructures

Md. Imran Hossain, Marta Switalska, Wei Peng, Mariko Takashima, Ning Wang, Marcel Kaiser, Joanna Wietrzyk, Shingo Dan, Takao Yamori, Tsutomu Inokuchi

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 69 294-309, Nov, 2013
In vitro antiproliferative activity of 11-aminoalkylamino-substituted 5H-indolo[2,3-b]quinolines; improving activity of neocryptolepines by installation of ester substituent

Wen-Jie Lu, Marta Switalska, Li Wang, Mizuki Yonezawa, Ibrahim El-Tantawy El-Sayed, Joanna Wietrzyk, Tsutomu Inokuchi

MEDICINAL CHEMISTRY RESEARCH, 22(9) 4492-4504, Sep, 2013
In vitro antiproliferative activity of 11-aminoalkylamino-substituted 5H-indolo[2,3-b]quinolines; improving activity of neocryptolepines by installation of ester substituent

Wen-Jie Lu, Marta Switalska, Li Wang, Mizuki Yonezawa, Ibrahim El-Tantawy El-Sayed, Joanna Wietrzyk, Tsutomu Inokuchi

MEDICINAL CHEMISTRY RESEARCH, 22(9) 4492-4504, Sep, 2013
Regioselective N-Methylation of 6-Chloroindolo[3,2-c]quinolines and Their Amination Reactivity at the C-6 Position

Ning Wang, Kento Imai, Cui-Qing Pang, Ming-qi Wang, Mizuho Yonezawa, Yu Zhang, Junzo Nokami, Tsutomu Inokuchi

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 86(7) 864-869, Jul, 2013
Annulation of 2H-Pyran onto 1-Oxa- or 1-Azacyclohexane-2,4-diones and Their Analogues via Sequential Condensation with alpha-Substituted Enals and 6 pi-Electrocyclization

Md. Imran Hossain, Elkhabiry Shaban, Taku Ikemi, Wei Peng, Hiroyuki Kawafuchi, Tsutomu Inokuchi

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 86(7) 870-879, Jul, 2013
Regioselective N-Methylation of 6-Chloroindolo[3,2-c]quinolines and Their Amination Reactivity at the C-6 Position

Ning Wang, Kento Imai, Cui-Qing Pang, Ming-qi Wang, Mizuho Yonezawa, Yu Zhang, Junzo Nokami, Tsutomu Inokuchi

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 86(7) 864-869, Jul, 2013
Annulation of 2H-Pyran onto 1-Oxa- or 1-Azacyclohexane-2,4-diones and Their Analogues via Sequential Condensation with alpha-Substituted Enals and 6 pi-Electrocyclization

Md. Imran Hossain, Elkhabiry Shaban, Taku Ikemi, Wei Peng, Hiroyuki Kawafuchi, Tsutomu Inokuchi

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 86(7) 870-879, Jul, 2013
Synthesis and in Vitro Antimalarial Testing of Neocryptolepines: SAR Study for Improved Activity by Introduction and Modifications of Side Chains at C2 and C11 on Indolo[2,3-b]quinolines

Zhen-Wu Mei, Li Wang, Wen-Jie Lu, Cui-Qing Pang, Tsukasa Maeda, Wei Peng, Marcel Kaiser, Ibrahim El Sayed, Tsutomu Inokuchi

JOURNAL OF MEDICINAL CHEMISTRY, 56(4) 1431-1442, Feb, 2013
Synthesis and in Vitro Antimalarial Testing of Neocryptolepines: SAR Study for Improved Activity by Introduction and Modifications of Side Chains at C2 and C11 on Indolo[2,3-b]quinolines

Zhen-Wu Mei, Li Wang, Wen-Jie Lu, Cui-Qing Pang, Tsukasa Maeda, Wei Peng, Marcel Kaiser, Ibrahim El Sayed, Tsutomu Inokuchi

JOURNAL OF MEDICINAL CHEMISTRY, 56(4) 1431-1442, Feb, 2013
Synthesis and in Vitro Testing of Antimalarial Activity of Non-natural-type Neocryptolepines: SAR Study of 2,11- and 9,11-Disubstituted 6-Methylindolo[2,3-b]quinolines

Ning Wang, Kathryn Jean Wicht, Li Wang, Wen-Jie Lu, Ryuhei Misumi, Ming-qi Wang, Ahmed Abdel Allem Aelgoha, Marcel Kaiser, Ibrahim El Tantawy El Sayed, Timothy John Egan …

Chem. Pharm. Bull. Jpn, 00 00-00, 2013
Cyclopentanoids from cyclopentadiene: Synthesis of (-)-methyl jasmonate and (+)-12-oxophytodienoic acid

Junzo Nokami, Kazuhiko Fujii, Yusuke Mizutani, Rikiya Omatsu, Kiyoshi Watanabe, Hiroshi Yasuda, Tsutomu Inokuchi

Natural Product Communications, 8(7) 919-923, 2013
Synthesis and antimalarial testing of neocryptolepine analogues: Addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines

Wen-Jie Lu, Kathryn J. Wicht, Li Wang, Kento Imai, Zhen-Wu Mei, Marcel Kaiser, Ibrahim El Tantawy El Sayed, Timothy J. Egan, Tsutomu Inokuchi

European Journal of Medicinal Chemistry, 64 498-511, 2013
Synthesis and in Vitro Testing of Antimalarial Activity of Non-natural-type Neocryptolepines: SAR Study of 2,11- and 9,11-Disubstituted 6-Methylindolo[2,3-b]quinolines

Ning Wang, Kathryn Jean Wicht, Li Wang, Wen-Jie Lu, Ryuhei Misumi, Ming-qi Wang, Ahmed Abdel Allem Aelgoha, Marcel Kaiser, Ibrahim El Tantawy El Sayed, Timothy John Egan …

Chem. Pharm. Bull. Jpn, 00 00-00, 2013
Cyclopentanoids from cyclopentadiene: Synthesis of (-)-methyl jasmonate and (+)-12-oxophytodienoic acid

Junzo Nokami, Kazuhiko Fujii, Yusuke Mizutani, Rikiya Omatsu, Kiyoshi Watanabe, Hiroshi Yasuda, Tsutomu Inokuchi

Natural Product Communications, 8(7) 919-923, 2013
Synthesis and antimalarial testing of neocryptolepine analogues: Addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines

Wen-Jie Lu, Kathryn J. Wicht, Li Wang, Kento Imai, Zhen-Wu Mei, Marcel Kaiser, Ibrahim El Tantawy El Sayed, Timothy J. Egan, Tsutomu Inokuchi

European Journal of Medicinal Chemistry, 64 498-511, 2013
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles

Wei Peng, Marta Switalska, Li Wang, Zhen-Wu Mei, Yoshiki Edazawa, Cui-Qing Pang, Ibrahim El-Tantawy El-Sayed, Joanna Wietrzyk, Tsutomu Inokuchi

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 58 441-451, Dec, 2012
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted chromeno[2,3-b]indoles

Wei Peng, Marta Switalska, Li Wang, Zhen-Wu Mei, Yoshiki Edazawa, Cui-Qing Pang, Ibrahim El-Tantawy El-Sayed, Joanna Wietrzyk, Tsutomu Inokuchi

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 58 441-451, Dec, 2012
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure-activity relationships of neocryptolepines and 6-methyl congeners

Li Wang, Marta Switalska, Zhen-Wu Mei, Wen-Jie Lu, Yoshito Takahara, Xing-Wen Feng, Ibrahim El-Tantawy El-Sayed, Joanna Wietrzyk, Tsutomu Inokuchi

BIOORGANIC & MEDICINAL CHEMISTRY, 20(15) 4820-4829, Aug, 2012
Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure-activity relationships of neocryptolepines and 6-methyl congeners

Li Wang, Marta Switalska, Zhen-Wu Mei, Wen-Jie Lu, Yoshito Takahara, Xing-Wen Feng, Ibrahim El-Tantawy El-Sayed, Joanna Wietrzyk, Tsutomu Inokuchi

BIOORGANIC & MEDICINAL CHEMISTRY, 20(15) 4820-4829, Aug, 2012

Books and Other Publications

Role of the Electrochemical Method in the Transformation of beta-Lactam Antibiotics and Terpenoids

Springer-Verlag
Addition Reactions with Formation of Carbon-Halogen Bonds

Pergamon Press
Role of the Electrochemical Method in the Transformation of beta-Lactam Antibiotics and Terpenoids

Springer-Verlag
Addition Reactions with Formation of Carbon-Halogen Bonds

Pergamon Press

Presentations

137

Benign Access to Indolequinolines as a Strategic Scaffold for Antiinfectious Agent

10th International Symposium on Organic Reactions (ISOR10), 2011
Synthesis of 2,3,6-Trisubstituted 2H-Pyran-5-carboxylates, Their Transformations and Biological Properties

10th International Symposium on Organic Reactions (ISOR10), 2011
Synthesis of F-Substituted 11-Chloroneocypotolepines from Indole-3-carboxylate and N-Methylanilines

第35回フッ素化学討論会, 2011
Micorowave-Assisted Multicomponent Reactions of 2-Haloketones and Enamines

第35回フッ素化学討論会, 2011
Micorowave-Assisted Multicomponent Reaction for Synthesis of α-Aminoketones

International Congress on Organic Chemistry (the Butlerov’s Congress) (the Butlerov’s Congress), 2011
Synthesis of Indolequinolines for Anti-infective and Anticancer Agents

International Congress on Organic Chemistry (the Butlerov’s Congress) (the Butlerov’s Congress), 2011
A Reductive Strategy for the Synthesis of Sulfones from Carbonyl Compounds

第２７回若手化学者のための化学道場（若手研究者のためのセミナー）, 2011
N-アルキルアニリンからインドールキノリン骨格の簡便な合成法

第２７回若手化学者のための化学道場（若手研究者のためのセミナー）, 2011
2-Substituted 11-Chloroneocypotolepines, a Strategic Scaffold for Antimalaria Agent, Starting with N-Methylanilines

第２回プロセス化学国際シンポジウム, 2011
Synthesis of Bioactive 4-Alkylidene-2-pentenolides from (E)-2-Hydroxymethyl-2-alkenals

第２回プロセス化学国際シンポジウム, 2011
Micorowave-Assisted Multicomponent Reaction; Synthesis of α-Aminoketones as a Precursor of Ephedrine Analogues

第２回プロセス化学国際シンポジウム, 2011
Buchwald-Hartwig反応によるN-アルキルアニリン合成とインドールキノリン骨格への応用

日本化学会９１春季年会, 2011
シンナモイルTEMPOへのMgアミドのジアステレオ選択的1,4-付加

日本化学会９１春季年会, 2011
無溶媒マイクロ波照射によるαハロケトンとエナミンの多成分連結反応

日本化学会９１春季年会, 2011
Synthesis of bioactive 4-alkylidene-2-pentenolides from (E)-2-hydroxymethyl-2-alkenals

第４回高度医療都市を創出する未来技術国際シンポジウム, 2011
Benign Access to Indolequinolines as a Strategic Scaffold for Antiinfectious Agent

10th International Symposium on Organic Reactions (ISOR10), 2011
Synthesis of 2,3,6-Trisubstituted 2H-Pyran-5-carboxylates, Their Transformations and Biological Properties

10th International Symposium on Organic Reactions (ISOR10), 2011
Synthesis of F-Substituted 11-Chloroneocypotolepines from Indole-3-carboxylate and N-Methylanilines

2011
Micorowave-Assisted Multicomponent Reactions of 2-Haloketones and Enamines

2011
Micorowave-Assisted Multicomponent Reaction for Synthesis of α-Aminoketones

International Congress on Organic Chemistry (the Butlerov's Congress), 2011

Professional Memberships

Works

超原子価ヨウ素化合物を利用した反応探索

2011
電解法による貯蔵可能な活性アニオン種の発生と有機合成への応用

2009 - 2010
落書き簡易除去方法に関する研究

2008 - 2009
電解法による貯蔵可能な活性アニオン種の発生と有機合成への応用

2008 - 2009
落書き簡易除去方法に関する研究

2007 - 2008
生体機能型遷移金属錯体をメディエーターに用いる有機合成法の開発

1993 - 1996
活性酸素種の電解並びに化学的合成法の確立とその応用

1993 - 1995

Research Projects

インドールキノリン系抗感染症剤、抗がん剤の設計と合成に関する研究

補助金, 2008
Design and syntheses of indolequinolines as anti-malaria and anticancer agents

Grants and Funding, 2008
炭素骨格の構築における立体制御ならびにバイオ資源のキラル生物活性分子への変換に関する研究

補助金, 2005
生体酵素モデル分子の電気化学的活性化法による分子変換および機能性分子の合成

補助金, 2005
カルボン酸誘導体の拡張分子の設計、反応性の解明

補助金, 2005
アルコールの触媒的酸化技術に関する研究

補助金, 2005
医用を目的とする含窒素ヘテロ環化合物の設計と合成に関する研究

補助金, 2005
Stereocontrol in construction of carbon-skeleton and syntheses of bioactive molecules from naturally abundant chiral biomass

Grants and Funding, 2005
Development of organic syntheses using model molecules of enzyme such as vitamin B12

Grants and Funding, 2005
Design of extended carboxylic derivatives, exploration of their reactivity, and synthetic applications

Grants and Funding, 2005
Development of environmentally friendly catalytic oxidation methods of alcohols and related compounds

Grants and Funding, 2005
Design and syntheses of biologically relevant nitrogen-containing heterocycles for medicinal applications

Grants and Funding, 2005
有機ラジカルTEMPOを用いる経済的な酸化反応の研究
クリーンな有機合成プロセスを指向する有機電解法の研究
生体機能の電気化学的解明に関する研究
生物活性分子の設計と合成に関する研究
Studies of Economically Viable Oxidation Methods Using Organic Radical TEMPO
Studies of Electroorganic Reactions towards Ecology-Friendly Synthetic Process
Studies on Electrochemical Approach to Bioorganic Reaction
Studies on Design and Synthesis of Bioactive Molecules

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Misc.

Books and Other Publications

Presentations

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Works

Research Projects

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