Papers

Open access International journal
Jun 2, 2021

Preparation of absorption-resistant hard tissue using dental pulp-derived cells and honeycomb tricalcium phosphate

Materials
  • Kiyofumi Takabatake
  • ,
  • Keisuke Nakano
  • ,
  • Hotaka Kawai
  • ,
  • Yasunori Inada
  • ,
  • Shintaro Sukegawa
  • ,
  • Shan Qiusheng
  • ,
  • Shigeko Fushimi
  • ,
  • Hidetsugu Tsujigiwa
  • ,
  • Hitoshi Nagatsuka

Volume
14
Number
12
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.3390/ma14123409
Publisher
MDPI

In recent years, there has been increasing interest in the treatment of bone defects using undifferentiated mesenchymal stem cells (MSCs) in vivo. Recently, dental pulp has been proposed as a promising source of pluripotent mesenchymal stem cells (MSCs), which can be used in various clinical applications. Dentin is the hard tissue that makes up teeth, and has the same composition and strength as bone. However, unlike bone, dentin is usually not remodeled under physiological conditions. Here, we generated odontoblast-like cells from mouse dental pulp stem cells and combined them with honeycomb tricalcium phosphate (TCP) with a 300 µm hole to create bone-like tissue under the skin of mice. The bone-like hard tissue produced in this study was different from bone tissue, i.e., was not resorbed by osteoclasts and was less easily absorbed than the bone tissue. It has been suggested that hard tissue-forming cells induced from dental pulp do not have the ability to induce osteoclast differentiation. Therefore, the newly created bone-like hard tissue has high potential for absorption-resistant hard tissue repair and regeneration procedures.

Link information
DOI
https://doi.org/10.3390/ma14123409
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34202970
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234467
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000666508000001&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85108999913&origin=inward Open access
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85108999913&origin=inward
ID information
  • DOI : 10.3390/ma14123409
  • eISSN : 1996-1944
  • Pubmed ID : 34202970
  • Pubmed Central ID : PMC8234467
  • SCOPUS ID : 85108999913
  • Web of Science ID : WOS:000666508000001

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