Papers

International journal
Aug 2, 2005

The engraftment of transplanted bone marrow-derived cells into the olfactory epithelium

Brain Research
  • Hidetsugu Tsujigiwa
  • ,
  • Kazunori Nishizaki
  • ,
  • Takanori Teshima
  • ,
  • Yasushi Takeda
  • ,
  • Junko Yoshinobu
  • ,
  • Ayako Takeuchi
  • ,
  • Yorihisa Orita
  • ,
  • Yuji Sugata
  • ,
  • Hitoshi Nagatsuka
  • ,
  • Noriyuki Nagai

Volume
1052
Number
1
First page
10
Last page
15
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/j.brainres.2005.05.061
Publisher
ELSEVIER SCIENCE BV

To investigate whether bone marrow cells migrate and are engrafted into the olfactory epithelium and differentiate into olfactory neurons, bone marrow cells of green fluorescence protein (GFP) mice were transplanted into lethally irradiated recipient mice. Immunohistochemical staining was performed to evaluate the engraftment of donor bone marrow cells into the olfactory epithelium. Immunostaining for GFP was found initially in the olfactory epithelium 2 weeks after bone marrow reconstruction. The percentage of GFP positive cells increased up to 12 months after bone marrow reconstruction. Double staining for GFP and olfactory marker protein showed that a population of the GFP-positive cells had characteristics of olfactory neurons. These results demonstrate that bone marrow cells can be engrafted in the olfactory epithelium and then differentiate into olfactory neuron cells. © 2005 Elsevier B.V. All rights reserved.

Link information
DOI
https://doi.org/10.1016/j.brainres.2005.05.061
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15996641
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000231454400002&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=23644441935&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=23644441935&origin=inward
ID information
  • DOI : 10.1016/j.brainres.2005.05.061
  • ISSN : 0006-8993
  • Pubmed ID : 15996641
  • SCOPUS ID : 23644441935
  • Web of Science ID : WOS:000231454400002

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