Papers

International journal
2009

Potential usage of ING family members in cancer diagnostics and molecular therapy

Current Drug Targets
  • Mehmet Gunduz
  • ,
  • Kadir Demircan
  • ,
  • Esra Gunduz
  • ,
  • Naoki Katase
  • ,
  • Ryo Tamamura
  • ,
  • Hitoshi Nagatsuka

Volume
10
Number
5
First page
465
Last page
476
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.2174/138945009788185086
Publisher
BENTHAM SCIENCE PUBL LTD

The Inhibitor of Growth (ING) gene family is an emerging putative type II tumor suppressor gene (TSG). Proteins of INGs (ING1-5), critical modulator of the histone code via PHD fingers, are able to suppress cell growth and proliferation, induce apoptosis, and modulate cell cycle progression. ING proteins are involved in transcriptional regulation of genes, such as the p53-inducible gene p21. ING proteins also serve as shuttling proteins between nucleus and cytoplasm, and dysregulation of this nucleocytoplasmic traffic has been shown in some cancer cells. In cancer cells, ING mRNA levels are often lost or suppressed but the genes are rarely mutated. Recently the potential roles of ING proteins as prognostic biomarkers, detection of aggressive behavior of the tumor as well as prediction of chemo-radiotherapy response have also emerged. In this review, we summarize the up-to-date knowledge on functions of the ING proteins, the protein status in human tumors and discuss as a potential target in the molecular diagnostics and therapy of cancer. © 2009 Bentham Science Publishers Ltd.

Link information
DOI
https://doi.org/10.2174/138945009788185086
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19442118
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000265680600008&DestApp=WOS_CPL
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650595192&origin=inward
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=67650595192&origin=inward
ID information
  • DOI : 10.2174/138945009788185086
  • ISSN : 1389-4501
  • eISSN : 1873-5592
  • Pubmed ID : 19442118
  • SCOPUS ID : 67650595192
  • Web of Science ID : WOS:000265680600008

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