2002年9月25日
Tyrosine kinase-type receptor ErbB4 in chondrocytes: interaction with connective tissue growth factor and distribution in cartilage.
FEBS letters
- 巻
- 528
- 号
- 1-3
- 開始ページ
- 109
- 終了ページ
- 13
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0014-5793(02)03263-5
- 出版者・発行元
- ELSEVIER SCIENCE BV
In order to identify receptor molecules that participate in the growth and differentiation of chondrocytes, we cloned a number of cDNA fragments from HCS-2/8 chondrocytic cells, by using tyrosine kinase-specific primers for amplification. The mRNA expression of one such receptor, ErbB4, was increased by connective tissue growth factor/hypertrophic chondrocyte-specific gene product (CTGF/Hcs24), which promotes all stages of the endochondral ossification in vitro. ErbB4 expression was observed through all stages of chondrocytic differentiation in vitro, corresponding to the wide distribution of CTGF/Hcs24 target cells. Furthermore, positive signals for erbB4 mRNA were detectable throughout most populations of chondrocytes, in growth and articular cartilage in vivo. These results demonstrate for the first time that ErbB4 is expressed in chondrocytes and may play some roles in chondrocytic growth and differentiation along with CTGF/Hcs24.
- リンク情報
- ID情報
-
- DOI : 10.1016/S0014-5793(02)03263-5
- ISSN : 0014-5793
- PubMed ID : 12297288
- Web of Science ID : WOS:000178282500021