2014年8月13日
Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy.
Scientific reports
- 巻
- 4
- 号
- 開始ページ
- 6044
- 終了ページ
- 6044
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1038/srep06044
- 出版者・発行元
- NATURE PUBLISHING GROUP
Bio-hybrid artificial organs are an attractive concept to restore organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid artificial organs, an artificial organ with fibrous connective tissues, including muscles, tendons and ligaments, has not been developed. Here, we have enveloped with embryonic dental follicle tissue around a HA-coated dental implant, and transplanted into the lower first molar region of a murine tooth-loss model. We successfully developed a novel fibrous connected tooth implant using a HA-coated dental implant and dental follicle stem cells as a bio-hybrid organ. This bio-hybrid implant restored physiological functions, including bone remodelling, regeneration of severe bone-defect and responsiveness to noxious stimuli, through regeneration with periodontal tissues, such as periodontal ligament and cementum. Thus, this study represents the potential for a next-generation bio-hybrid implant for tooth loss as a future bio-hybrid artificial organ replacement therapy.
- リンク情報
-
- DOI
- https://doi.org/10.1038/srep06044
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/25116435
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131220
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000340674400004&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1038/srep06044
- ISSN : 2045-2322
- PubMed ID : 25116435
- PubMed Central 記事ID : PMC4131220
- Web of Science ID : WOS:000340674400004