MISC

国際誌
2016年3月

Sleep bruxism frequency and platelet serotonin transporter activities in young adult subjects.

Sleep & breathing = Schlaf & Atmung
  • Hajime Minakuchi
  • ,
  • Chiharu Sogawa
  • ,
  • Haruna Miki
  • ,
  • Emilio S Hara
  • ,
  • Kenji Maekawa
  • ,
  • Norio Sogawa
  • ,
  • Shigeo Kitayama
  • ,
  • Yoshizo Matsuka
  • ,
  • Glenn Thomas Clark
  • ,
  • Takuo Kuboki

20
1
開始ページ
271
終了ページ
6
記述言語
英語
掲載種別
DOI
10.1007/s11325-015-1281-0
出版者・発行元
SPRINGER HEIDELBERG

PURPOSE: To evaluate correlations between serotonin transporter (SERT) uptake ability in human peripheral platelets and sleep bruxism (SB) frequency. METHODS: Subjects were consecutively recruited from sixth-year students at Okayama University Dental School. Subjects were excluded if they (1) were receiving orthodontic treatment, (2) had a dermatological disease, (3) had taken an antidepressant within 6 months, or (4) had used an oral appliance within 6 months. SB frequency was determined as the summary score of three consecutive night assessments using a self-contained electromyography detector/analyzer in their home. Fasting peripheral venous blood samples were collected in the morning following the final SB assessment. SERT amount and platelet number were quantified via an ELISA assay and flow cytometry, respectively. Functional SERT characterization, 5-hydroxytryptamine (5-HT) uptake, maximum velocity (V max), and an affinity constant (K m ) were assessed with a [(3)H] 5-HT uptake assay. The correlations between these variables and SB level were evaluated. RESULTS: Among 50 eligible subjects (26 males, mean age 25.4 ± 2.41 years), 7 were excluded because of venipuncture failure, smoking, and alcohol intake during the experimental period. A small but significant negative correlation between SB level and [(3)H] 5-HT uptake was observed (Spearman's correlation R (2) = 0.063, p = 0.04). However, there were no significant correlations between SB level and total platelet amount, SERT, V max, and K m values (p = 0.08, 0.12, 0.71, and 0.68, respectively). CONCLUSIONS: Platelet serotonin uptake is significantly associated with SB frequency, yet only explains a small amount of SB variability.

リンク情報
DOI
https://doi.org/10.1007/s11325-015-1281-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26527205
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000372160800044&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s11325-015-1281-0
  • ISSN : 1520-9512
  • eISSN : 1522-1709
  • ORCIDのPut Code : 29713350
  • PubMed ID : 26527205
  • Web of Science ID : WOS:000372160800044

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