2000年
Effective production of dehydro cyclic dipeptide albonoursin exhibiting pronuclear fusion inhibitory activity II. Biosynthetic and bioconversion studies
Journal of Antibiotics
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- ,
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- 巻
- 53
- 号
- 1
- 開始ページ
- 58
- 終了ページ
- 62
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.7164/antibiotics.53.58
- 出版者・発行元
- Japan Antibiotics Research Association
Albornoursin production was greatly enhanced when cycle (r-Leu-L-Phe) (CFL), a tetrahydro derivative of albonoursin, was added to the 2-day culture of an albonoursin-producing actinomycete, Streptomyces albulus KO-23. The increase in albonoursin production paralleled the amount of CFL added. Furthermore, the resting cells of the strain catalyzed the bioconversion of CFL to albonoursin. The optimum pH and temperature for the conversion were found to be pH 10.0 and 50°C. The feeding experiments and the resting-cell reactions revealed that albonoursin is biosynthesized by dehydrogenation of CFL in the actinomycete. This is the first report for a dehydrogenation of amino acid residues at the α,β-positions in cyclic dipeptides.
- リンク情報
- ID情報
-
- DOI : 10.7164/antibiotics.53.58
- ISSN : 0021-8820
- PubMed ID : 10724009
- SCOPUS ID : 0033980537